Literature DB >> 20697753

Genetic aspects of osteoporosis.

Takayuki Hosoi1.   

Abstract

The multiple factors contributing to the pathogenesis of osteoporosis include genetic and environmental factors. Because decrease in bone mineral density (BMD) is the major clinical indicator and a useful quantitative trait, many association and linkage studies of BMD have been conducted. Although the series of studies showed apparently significant associations, the genes have not been found that can be utilized in clinical practice. Several genes identified in robust genome-wide association studies will be the new cutting edge in genetic studies of osteoporosis. Our recent reports of functional single nucleotide polymorphism in the tissue-nonspecific alkaline phosphatase gene and gamma-carboxylase gene are presented in this review to discuss the future prospects in the genetic research of osteoporosis from the point of view of genome-nutrition interaction.

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Year:  2010        PMID： 20697753     DOI： 10.1007/s00774-010-0217-9

Source DB:  PubMed          Journal:  J Bone Miner Metab        ISSN： 0914-8779            Impact factor:   2.626


  60 in total

Review 1.  Genetic associations in large versus small studies: an empirical assessment.

Authors:  John P A Ioannidis; Thomas A Trikalinos; Evangelia E Ntzani; Despina G Contopoulos-Ioannidis
Journal:  Lancet       Date:  2003-02-15       Impact factor: 79.321

2.  Association of genetic variation of the RIL gene, encoding a PDZ-LIM domain protein and localized in 5q31.1, with low bone mineral density in adult Japanese women.

Authors:  Fumihiro Omasu; Yoichi Ezura; Mitsuko Kajita; Ryota Ishida; Mina Kodaira; Hideo Yoshida; Takao Suzuki; Takayuki Hosoi; Satoshi Inoue; Masataka Shiraki; Hajime Orimo; Mitsuru Emi
Journal:  J Hum Genet       Date:  2003-06-06       Impact factor: 3.172

3.  LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.

Authors:  Y Gong; R B Slee; N Fukai; G Rawadi; S Roman-Roman; A M Reginato; H Wang; T Cundy; F H Glorieux; D Lev; M Zacharin; K Oexle; J Marcelino; W Suwairi; S Heeger; G Sabatakos; S Apte; W N Adkins; J Allgrove; M Arslan-Kirchner; J A Batch; P Beighton; G C Black; R G Boles; L M Boon; C Borrone; H G Brunner; G F Carle; B Dallapiccola; A De Paepe; B Floege; M L Halfhide; B Hall; R C Hennekam; T Hirose; A Jans; H Jüppner; C A Kim; K Keppler-Noreuil; A Kohlschuetter; D LaCombe; M Lambert; E Lemyre; T Letteboer; L Peltonen; R S Ramesar; M Romanengo; H Somer; E Steichen-Gersdorf; B Steinmann; B Sullivan; A Superti-Furga; W Swoboda; M J van den Boogaard; W Van Hul; M Vikkula; M Votruba; B Zabel; T Garcia; R Baron; B R Olsen; M L Warman
Journal:  Cell       Date:  2001-11-16       Impact factor: 41.582

4.  A polymorphic variant at the Werner helicase (WRN) gene is associated with bone density, but not spondylosis, in postmenopausal women.

Authors:  N Ogata; M Shiraki; T Hosoi; Y Koshizuka; K Nakamura; H Kawaguchi
Journal:  J Bone Miner Metab       Date:  2001       Impact factor: 2.626

5.  Association of a promoter haplotype (-1542G/-525C) in the tumor necrosis factor receptor associated factor-interacting protein gene with low bone mineral density in Japanese women.

Authors:  Ryota Ishida; Yoichi Ezura; Mitsuru Emi; Mitsuko Kajita; Hideo Yoshida; Takao Suzuki; Takayuki Hosoi; Satoshi Inoue; Masataka Shiraki; Hiromoto Ito; Hajime Orimo
Journal:  Bone       Date:  2003-08       Impact factor: 4.398

6.  Functional assay of the mutant tissue-nonspecific alkaline phosphatase gene using U2OS osteoblast-like cells.

Authors:  Hideo Orimo; Masae Goseki-Sone; Takayuki Hosoi; Takashi Shimada
Journal:  Mol Genet Metab       Date:  2008-05-01       Impact factor: 4.797

7.  Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies.

Authors:  Annie W C Kung; Su-Mei Xiao; Stacey Cherny; Gloria H Y Li; Yi Gao; Gloria Tso; Kam S Lau; Keith D K Luk; Jian-min Liu; Bin Cui; Min-Jia Zhang; Zhen-lin Zhang; Jin-wei He; Hua Yue; Wia-bo Xia; Lian-mei Luo; Shu-li He; Douglas P Kiel; David Karasik; Yi-Hsiang Hsu; L Adrienne Cupples; Serkalem Demissie; Unnur Styrkarsdottir; Bjarni V Halldorsson; Gunnar Sigurdsson; Unnur Thorsteinsdottir; Kari Stefansson; J Brent Richards; Guangju Zhai; Nicole Soranzo; Ana Valdes; Tim D Spector; Pak C Sham
Journal:  Am J Hum Genet       Date:  2010-01-21       Impact factor: 11.025

8.  International variations in hip fracture probabilities: implications for risk assessment.

Authors:  John A Kanis; Olof Johnell; Chris De Laet; Bengt Jonsson; Anders Oden; Alan K Ogelsby
Journal:  J Bone Miner Res       Date:  2002-07       Impact factor: 6.741

9.  Association of multiple nucleotide variations in the pituitary glutaminyl cyclase gene (QPCT) with low radial BMD in adult women.

Authors:  Yoichi Ezura; Mitsuko Kajita; Ryota Ishida; Shoko Yoshida; Hideyo Yoshida; Takao Suzuki; Takayuki Hosoi; Satoshi Inoue; Masataka Shiraki; Hajime Orimo; Mitsuru Emi
Journal:  J Bone Miner Res       Date:  2004-03-29       Impact factor: 6.741

10.  Association of klotho gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women.

Authors:  N Ogata; Y Matsumura; M Shiraki; K Kawano; Y Koshizuka; T Hosoi; K Nakamura; M Kuro-O; H Kawaguchi
Journal:  Bone       Date:  2002-07       Impact factor: 4.398
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  12 in total

1.  Association of MTHFR C667T polymorphism with bone mineral density and fracture risk: an updated meta-analysis.

Authors:  H Wang; C Liu
Journal:  Osteoporos Int       Date:  2011-12-21       Impact factor: 4.507

2.  Association between vitamin D receptor gene polymorphisms and bone mineral density in Chinese women.

Authors:  Yufei Li; Bo Xi; Kanghua Li; Chunyu Wang
Journal:  Mol Biol Rep       Date:  2011-12-23       Impact factor: 2.316

3.  Evaluation of common variants in CNR2 gene for bone mineral density and osteoporosis susceptibility in postmenopausal women of Han Chinese.

Authors:  C Zhang; J Ma; G Chen; D Fu; L Li; M Li
Journal:  Osteoporos Int       Date:  2015-06-09       Impact factor: 4.507

4.  Electrospinning collagen and hyaluronic acid nanofiber meshes.

Authors:  Rachael L Fischer; Michael G McCoy; Sheila A Grant
Journal:  J Mater Sci Mater Med       Date:  2012-04-12       Impact factor: 3.896

5.  TNFRSF11B gene polymorphisms, bone mineral density, and fractures in Slovak postmenopausal women.

Authors:  Iveta Boroňová; Jarmila Bernasovská; Soňa Mačeková; Eva Petrejčíková; Zlatica Tomková; Ján Kľoc; Janka Poráčová; Marta Mydlárová Blaščáková; Eva Litavcová
Journal:  J Appl Genet       Date:  2014-10-17       Impact factor: 3.240

6.  Quantitative assessment of the associations between MTHFR C677T and A1298C polymorphisms and risk of fractures: a meta-analysis.

Authors:  Rui Bai; Wanlin Liu; Aiqing Zhao; Zhenqun Zhao; Dianming Jiang
Journal:  Mol Biol Rep       Date:  2012-12-11       Impact factor: 2.316

7.  Association analyses of osteoprotegerin gene polymorphisms with bone mineral density in Chinese postmenopausal women.

Authors:  Feng Zhang; Chunlei He; Gang Chen; Fangcai Li; Hui Gao
Journal:  Med Oncol       Date:  2013-01-19       Impact factor: 3.064

8.  Association analyses of FGFR2 gene polymorphisms with femoral neck bone mineral density in Chinese Han population.

Authors:  Shan-Shan Dong; Tie-Lin Yang; Han Yan; Zheng-Qin Rong; Jia-Bin Chen; Ruo-Han Hao; Xiao-Feng Chen; Yan Guo
Journal:  Mol Genet Genomics       Date:  2014-10-10       Impact factor: 3.291

9.  The influence of vitamin D receptor genetic variants on bone mineral density and osteoporosis in Chinese postmenopausal women.

Authors:  Wei He; Ming Liu; Xiaonan Huang; Zuhong Qing; Wei Gao
Journal:  Dis Markers       Date:  2015-02-17       Impact factor: 3.434

10.  Association analysis between g.18873C>T and g.27522G>A genetic polymorphisms of OPG and bone mineral density in Chinese postmenopausal women.

Authors:  Fei Wang; Yi Cao; Fang Li; Jianlin Shan; Tianlin Wen
Journal:  Biomed Res Int       Date:  2014-12-15       Impact factor: 3.411
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