C Zhang1, J Ma1, G Chen2, D Fu2, L Li2, M Li3. 1. The First Department of Orthopedics, the Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 157 Xiwu road, Xi'an, 710061, China. 2. College of Medicine & Forensics, Xi'an Jiaotong University, 76 West Yanta road, Xi'an, 710061, China. 3. Department of Ultrasound, the Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 157 Xiwu road, Xi'an, 710061, China. 18209277651@163.com.
Abstract
UNLABELLED: Postmenopausal osteoporosis is a major health problem with important genetic factors in postmenopausal women. We thoroughly evaluated the relationship of CNR2 polymorphisms with osteoporosis in a cohort of 1032 osteoporosis patients and 2089 healthy controls from Han Chinese postmenopausal women. Statistically significant differences, depending on different genotypes, were presented. INTRODUCTION: Osteoporosis is a major health problem in postmenopausal women, which is a multifactorial disease in which genetic determinants are modulated by hormonal, environmental, and nutritional factors. An important clinical risk factor in the pathogenesis of osteoporosis is the presence of genetic polymorphism in susceptibility genes. The aim of our study was to investigate whether CNR2 gene, which attributes to osteoporosis susceptibility in some populations, is associated with bone mineral density (BMD) or osteoporosis in Han Chinese postmenopausal women. METHODS: We examine 39 SNPs covering the region of CNR2 gene in 3121 Han Chinese postmenopausal women, consisting of 1032 osteoporosis patients and 2089 healthy controls, to evaluate the association with BMD and osteoporosis. RESULTS: We found that rs4237 and rs2501431 were significantly associated with BMD and osteoporosis (corrected p = 0.020085 and 0.017199) in our sample, and the TT genotype of rs2501431 and the AA genotype of rs4237 had lower lumbar spine BMD and femoral neck BMD compared with the other genotypes. Additionally, analyses by haplotypes indicated that two haplotype blocks, containing rs4237 and rs2501431 respectively, in the CNR2 gene significantly associated with BMD and osteoporosis (both global permutation p < 0.001), and a risk haplotype (ATTT) in the block of rs3003336-rs2501431-rs2502992-rs2501432 had almost 4-fold increase in the cases. CONCLUSIONS: Our results provide further supportive evidence for an important role of CNR2 gene in the etiology of osteoporosis and suggest that it may be a genetic risk factor for BMD and osteoporosis in Han Chinese postmenopausal women.
UNLABELLED: Postmenopausal osteoporosis is a major health problem with important genetic factors in postmenopausal women. We thoroughly evaluated the relationship of CNR2 polymorphisms with osteoporosis in a cohort of 1032 osteoporosispatients and 2089 healthy controls from Han Chinese postmenopausal women. Statistically significant differences, depending on different genotypes, were presented. INTRODUCTION:Osteoporosis is a major health problem in postmenopausal women, which is a multifactorial disease in which genetic determinants are modulated by hormonal, environmental, and nutritional factors. An important clinical risk factor in the pathogenesis of osteoporosis is the presence of genetic polymorphism in susceptibility genes. The aim of our study was to investigate whether CNR2 gene, which attributes to osteoporosis susceptibility in some populations, is associated with bone mineral density (BMD) or osteoporosis in Han Chinese postmenopausal women. METHODS: We examine 39 SNPs covering the region of CNR2 gene in 3121 Han Chinese postmenopausal women, consisting of 1032 osteoporosispatients and 2089 healthy controls, to evaluate the association with BMD and osteoporosis. RESULTS: We found that rs4237 and rs2501431 were significantly associated with BMD and osteoporosis (corrected p = 0.020085 and 0.017199) in our sample, and the TT genotype of rs2501431 and the AA genotype of rs4237 had lower lumbar spine BMD and femoral neck BMD compared with the other genotypes. Additionally, analyses by haplotypes indicated that two haplotype blocks, containing rs4237 and rs2501431 respectively, in the CNR2 gene significantly associated with BMD and osteoporosis (both global permutation p < 0.001), and a risk haplotype (ATTT) in the block of rs3003336-rs2501431-rs2502992-rs2501432 had almost 4-fold increase in the cases. CONCLUSIONS: Our results provide further supportive evidence for an important role of CNR2 gene in the etiology of osteoporosis and suggest that it may be a genetic risk factor for BMD and osteoporosis in Han Chinese postmenopausal women.
Entities:
Keywords:
Bone mineral density; CNR2 gene; Osteoporosis; Postmenopausal women; Single-nucleotide polymorphisms
Authors: Meliha Karsak; Ida Malkin; Mohammad R Toliat; Christian Kubisch; Peter Nürnberg; Andreas Zimmer; Gregory Livshits Journal: Hum Genet Date: 2009-06-30 Impact factor: 4.132
Authors: M Devoto; K Shimoya; J Caminis; J Ott; A Tenenhouse; M P Whyte; L Sereda; S Hall; E Considine; C J Williams; G Tromp; H Kuivaniemi; L Ala-Kokko; D J Prockop; L D Spotila Journal: Eur J Hum Genet Date: 1998 Mar-Apr Impact factor: 4.246