AIM: To determine the accuracy of computed tomography (CT) in detecting disease with invasion beyond the muscularis propria (MP) and malignant lymph nodes. MATERIALS AND METHODS: A literature search of Ovid, Embase, the Cochrane database, and Medline using Pubmed, Google Scholar and Vivisimo search engines was performed to identify studies reporting on the accuracy of CT to predict the staging of colonic tumours. Publication bias was demonstrated by Funnel plots. The sensitivity, specificity, and diagnostic odds ratio (DOR) were calculated using a bivariate random effects model and hierarchical summary operating curves (HSROC) were generated. RESULTS: Nineteen studies fulfilled all the necessary inclusion criteria. The pooled sensitivity, specificity, DOR for detection of tumour invasion were 86% (95% CI: 78-92%); 78% (95% CI: 71-84%); 22.4 (95% CI: 11.9-42.4). Similarly, the values for nodal detection were 70% (95% CI: 63-73%); 78% (95% CI: 73-82%); 8.1(95% CI: 4.7-14.1). In the subgroup analysis, the best results were obtained in studies utilizing multidetector CT (MDCT). CONCLUSION: Preoperative staging CT accurately distinguishes between tumours confined to the bowel wall and those invading beyond the MP; however, it is significantly poorer at identifying nodal status. MDCT provides the best results.
AIM: To determine the accuracy of computed tomography (CT) in detecting disease with invasion beyond the muscularis propria (MP) and malignant lymph nodes. MATERIALS AND METHODS: A literature search of Ovid, Embase, the Cochrane database, and Medline using Pubmed, Google Scholar and Vivisimo search engines was performed to identify studies reporting on the accuracy of CT to predict the staging of colonic tumours. Publication bias was demonstrated by Funnel plots. The sensitivity, specificity, and diagnostic odds ratio (DOR) were calculated using a bivariate random effects model and hierarchical summary operating curves (HSROC) were generated. RESULTS: Nineteen studies fulfilled all the necessary inclusion criteria. The pooled sensitivity, specificity, DOR for detection of tumour invasion were 86% (95% CI: 78-92%); 78% (95% CI: 71-84%); 22.4 (95% CI: 11.9-42.4). Similarly, the values for nodal detection were 70% (95% CI: 63-73%); 78% (95% CI: 73-82%); 8.1(95% CI: 4.7-14.1). In the subgroup analysis, the best results were obtained in studies utilizing multidetector CT (MDCT). CONCLUSION: Preoperative staging CT accurately distinguishes between tumours confined to the bowel wall and those invading beyond the MP; however, it is significantly poorer at identifying nodal status. MDCT provides the best results.
Authors: Audrey H Choi; Rebecca A Nelson; Hans F Schoellhammer; Won Cho; Michelle Ko; Amanda Arrington; Christopher R Oxner; Marwan Fakih; Jimmie Wong; Stephen M Sentovich; Julio Garcia-Aguilar; Joseph Kim Journal: World J Gastrointest Surg Date: 2015-07-27
Authors: A Carrara; M Motter; D Amabile; L Pellecchia; P Moscatelli; R Pertile; M Barbareschi; N L Decarli; M Ferrari; G Tirone Journal: Int J Colorectal Dis Date: 2020-06-16 Impact factor: 2.571
Authors: A Venara; C Ridereau-Zins; L Toque; E Cesbron; S Michalak; E Lermite; C Aube; A Hamy Journal: Int J Colorectal Dis Date: 2015-02-27 Impact factor: 2.571
Authors: Ahmed N Dehal; Amanda N Graff-Baker; Brooke Vuong; Daniel Nelson; Shu-Ching Chang; David Y Lee; Melanie Goldfarb; Anton J Bilchik Journal: J Gastrointest Surg Date: 2018-05-22 Impact factor: 3.452
Authors: M L Malmstrøm; S Brisling; T W Klausen; A Săftoiu; T Perner; P Vilmann; I Gögenur Journal: Int J Colorectal Dis Date: 2017-11-07 Impact factor: 2.571