Literature DB >> 20677799

Role of endosomal escape for disulfide-based drug delivery from colloidal mesoporous silica evaluated by live-cell imaging.

Anna M Sauer1, Axel Schlossbauer, Nadia Ruthardt, Valentina Cauda, Thomas Bein, Christoph Bräuchle.   

Abstract

Redox-driven intracellular disulfide-cleavage is a promising strategy to achieve stimuli-responsive and controlled drug release. We synthesized colloidal mesoporous silica (CMS) nanoparticles with ATTO633-labeled cysteine linked to the inner particle core via disulfide-bridges and characterized their cysteine release behavior after internalization into HuH7 cells by high-resolution fluorescence microscopy. Our study revealed that endosomal escape is a bottleneck for disulfide-linkage based drug release. Photochemical opening of the endosome leads to successful delivery of fluorescently labeled cysteine to the cytosol.

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Year:  2010        PMID： 20677799     DOI： 10.1021/nl102180s

Source DB:  PubMed          Journal:  Nano Lett        ISSN： 1530-6984            Impact factor:   11.189


  19 in total

Review 1.  Development of mesoporous silica nanomaterials as a vehicle for anticancer drug delivery.

Authors:  Rolando E Yanes; Fuyuhiko Tamanoi
Journal:  Ther Deliv       Date:  2012-03

2.  Delivery of small interfering RNA by peptide-targeted mesoporous silica nanoparticle-supported lipid bilayers.

Authors:  Carlee E Ashley; Eric C Carnes; Katharine E Epler; David P Padilla; Genevieve K Phillips; Robert E Castillo; Dan C Wilkinson; Brian S Wilkinson; Cameron A Burgard; Robin M Kalinich; Jason L Townson; Bryce Chackerian; Cheryl L Willman; David S Peabody; Walker Wharton; C Jeffrey Brinker
Journal:  ACS Nano       Date:  2012-02-14       Impact factor: 15.881

3.  Monitoring the Stimulated Uncapping Process of Gold-Capped Mesoporous Silica Nanoparticles.

Authors:  Ashley E Augspurger; Xiaoxing Sun; Brian G Trewyn; Ning Fang; Anthony S Stender
Journal:  Anal Chem       Date:  2018-02-15       Impact factor: 6.986

Review 4.  Mechanized silica nanoparticles: a new frontier in theranostic nanomedicine.

Authors:  Michael W Ambrogio; Courtney R Thomas; Yan-Li Zhao; Jeffrey I Zink; J Fraser Stoddart
Journal:  Acc Chem Res       Date:  2011-06-15       Impact factor: 22.384

5.  Peptide modified mesoporous silica nanocontainers.

Authors:  Fabiola Porta; Gerda E M Lamers; Jeffrey I Zink; Alexander Kros
Journal:  Phys Chem Chem Phys       Date:  2011-06-07       Impact factor: 3.676

Review 6.  Labeling and functionalizing amphipols for biological applications.

Authors:  Christel Le Bon; Jean-Luc Popot; Fabrice Giusti
Journal:  J Membr Biol       Date:  2014-04-03       Impact factor: 1.843

7.  Involvement of lysosomal exocytosis in the excretion of mesoporous silica nanoparticles and enhancement of the drug delivery effect by exocytosis inhibition.

Authors:  Rolando E Yanes; Derrick Tarn; Angela A Hwang; Daniel P Ferris; Sean P Sherman; Courtney R Thomas; Jie Lu; April D Pyle; Jeffrey I Zink; Fuyuhiko Tamanoi
Journal:  Small       Date:  2012-11-14       Impact factor: 13.281

8.  Versatile fluorescence resonance energy transfer-based mesoporous silica nanoparticles for real-time monitoring of drug release.

Authors:  Jinping Lai; Birju P Shah; Eric Garfunkel; Ki-Bum Lee
Journal:  ACS Nano       Date:  2013-03-11       Impact factor: 15.881

9.  Efficient delivery of cyclic peptides into mammalian cells with short sequence motifs.

Authors:  Ziqing Qian; Tao Liu; Yu-Yu Liu; Roger Briesewitz; Amy M Barrios; Sissy M Jhiang; Dehua Pei
Journal:  ACS Chem Biol       Date:  2012-11-12       Impact factor: 5.100

10.  Delivery of ricin toxin a-chain by peptide-targeted mesoporous silica nanoparticle-supported lipid bilayers.

Authors:  Katharine Epler; David Padilla; Genevieve Phillips; Peter Crowder; Robert Castillo; Dan Wilkinson; Brian Wilkinson; Cameron Burgard; Robin Kalinich; Jason Townson; Bryce Chackerian; Cheryl Willman; David Peabody; Walker Wharton; C Jeffrey Brinker; Carlee Ashley; Eric Carnes
Journal:  Adv Healthc Mater       Date:  2012-04-02       Impact factor: 9.933
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