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Literature DB >> 23184753

Delivery of ricin toxin a-chain by peptide-targeted mesoporous silica nanoparticle-supported lipid bilayers.

Katharine Epler¹, David Padilla, Genevieve Phillips, Peter Crowder, Robert Castillo, Dan Wilkinson, Brian Wilkinson, Cameron Burgard, Robin Kalinich, Jason Townson, Bryce Chackerian, Cheryl Willman, David Peabody, Walker Wharton, C Jeffrey Brinker, Carlee Ashley, Eric Carnes.

Abstract

Mesoporous silica nanoparticle-supported lipid bilayers, or "protocells", exhibit a high loading capacity, enhanced colloidal stability, and peptide-directed, cell-specific uptake, making them especially well-suited for targeted delivery of protein toxins to cancer. Protocells loaded with ricin toxin A-chain (RTA) and targeted to hepatocellular carcinoma cause complete cell death at 30 pM of RTA without affecting the viability of control hepatocytes.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：

Year: 2012 PMID： 23184753 PMCID： PMC4119887 DOI： 10.1002/adhm.201200022

Source DB: PubMed Journal: Adv Healthc Mater ISSN： 2192-2640 Impact factor: 9.933

24 in total

1. Delivery of small interfering RNA by peptide-targeted mesoporous silica nanoparticle-supported lipid bilayers.

Authors: Carlee E Ashley; Eric C Carnes; Katharine E Epler; David P Padilla; Genevieve K Phillips; Robert E Castillo; Dan C Wilkinson; Brian S Wilkinson; Cameron A Burgard; Robin M Kalinich; Jason L Townson; Bryce Chackerian; Cheryl L Willman; David S Peabody; Walker Wharton; C Jeffrey Brinker
Journal: ACS Nano Date: 2012-02-14 Impact factor: 15.881

Review 2. Immunotoxin therapy of cancer.

Authors: Ira Pastan; Raffit Hassan; David J Fitzgerald; Robert J Kreitman
Journal: Nat Rev Cancer Date: 2006-07 Impact factor: 60.716

Review 3. Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery.

Authors: Monty Liong; Jie Lu; Michael Kovochich; Tian Xia; Stefan G Ruehm; Andre E Nel; Fuyuhiko Tamanoi; Jeffrey I Zink
Journal: ACS Nano Date: 2008-05 Impact factor: 15.881

Review 4. Immunotoxin treatment of cancer.

Authors: Ira Pastan; Raffit Hassan; David J FitzGerald; Robert J Kreitman
Journal: Annu Rev Med Date: 2007 Impact factor: 13.739

5. Functional characterization of an endosome-disruptive peptide and its application in cytosolic delivery of immunoliposome-entrapped proteins.

Authors: Enrico Mastrobattista; Gerben A Koning; Louis van Bloois; Ana C S Filipe; Wim Jiskoot; Gert Storm
Journal: J Biol Chem Date: 2002-05-20 Impact factor: 5.157

6. Tumor cell killing enabled by listeriolysin O-liposome-mediated delivery of the protein toxin gelonin.

Authors: Chester J Provoda; Ethan M Stier; Kyung-Dall Lee
Journal: J Biol Chem Date: 2003-06-27 Impact factor: 5.157

7. Hepatocellular carcinoma cell-specific peptide ligand for targeted drug delivery.

Authors: Albert Lo; Chin-Tarng Lin; Han-Chung Wu
Journal: Mol Cancer Ther Date: 2008-03 Impact factor: 6.261

Review 8. Ricin. Mechanisms of cytotoxicity.

Authors: Michael J Lord; Nicholas A Jolliffe; Catherine J Marsden; Cassandra S Pateman; Daniel C Smith; Robert A Spooner; Peter D Watson; Lynne M Roberts
Journal: Toxicol Rev Date: 2003

9. The effect of endosomal escape peptides on in vitro gene delivery of polyethylene glycol-based vehicles.

Authors: Nicole M Moore; Clayton L Sheppard; Tiffany R Barbour; Shelly E Sakiyama-Elbert
Journal: J Gene Med Date: 2008-10 Impact factor: 4.565

10. CAT-8015: a second-generation pseudomonas exotoxin A-based immunotherapy targeting CD22-expressing hematologic malignancies.

Authors: Ralph F Alderson; Robert J Kreitman; Tianling Chen; Peter Yeung; Ronald Herbst; Judy A Fox; Ira Pastan
Journal: Clin Cancer Res Date: 2009-02-01 Impact factor: 13.801

12 in total

1. Ligand-directed profiling of organelles with internalizing phage libraries.

Authors: Andrey S Dobroff; Roberto Rangel; Liliana Guzman-Roja; Carolina C Salmeron; Juri G Gelovani; Richard L Sidman; Cristian G Bologa; Tudor I Oprea; C Jeffrey Brinker; Renata Pasqualini; Wadih Arap
Journal: Curr Protoc Protein Sci Date: 2015-02-02

Review 2. Protocells: Modular Mesoporous Silica Nanoparticle-Supported Lipid Bilayers for Drug Delivery.

Authors: Kimberly S Butler; Paul N Durfee; Christophe Theron; Carlee E Ashley; Eric C Carnes; C Jeffrey Brinker
Journal: Small Date: 2016-01-18 Impact factor: 13.281

Review 3. Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

Authors: María Vallet-Regí; Ferdi Schüth; Daniel Lozano; Montserrat Colilla; Miguel Manzano
Journal: Chem Soc Rev Date: 2022-07-04 Impact factor: 60.615

Review 4. Membrane mimetic surface functionalization of nanoparticles: methods and applications.

Authors: Jacob Weingart; Pratima Vabbilisetty; Xue-Long Sun
Journal: Adv Colloid Interface Sci Date: 2013-05-02 Impact factor: 12.984

Review 5. Ligand-targeted theranostic nanomedicines against cancer.

Authors: Virginia J Yao; Sara D'Angelo; Kimberly S Butler; Christophe Theron; Tracey L Smith; Serena Marchiò; Juri G Gelovani; Richard L Sidman; Andrey S Dobroff; C Jeffrey Brinker; Andrew R M Bradbury; Wadih Arap; Renata Pasqualini
Journal: J Control Release Date: 2016-01-06 Impact factor: 9.776

Review 6. Potential therapeutic applications of plant toxin-ricin in cancer: challenges and advances.

Authors: Nikhil Tyagi; Monika Tyagi; Manendra Pachauri; Prahlad C Ghosh
Journal: Tumour Biol Date: 2015-09-09

7. Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release.

Authors: Hitomi Hosoya; Andrey S Dobroff; Wouter H P Driessen; Vittorio Cristini; Lina M Brinker; Fernanda I Staquicini; Marina Cardó-Vila; Sara D'Angelo; Fortunato Ferrara; Bettina Proneth; Yu-Shen Lin; Darren R Dunphy; Prashant Dogra; Marites P Melancon; R Jason Stafford; Kohei Miyazono; Juri G Gelovani; Kazunori Kataoka; C Jeffrey Brinker; Richard L Sidman; Wadih Arap; Renata Pasqualini
Journal: Proc Natl Acad Sci U S A Date: 2016-02-02 Impact factor: 11.205