Literature DB >> 23152124

Involvement of lysosomal exocytosis in the excretion of mesoporous silica nanoparticles and enhancement of the drug delivery effect by exocytosis inhibition.

Rolando E Yanes1, Derrick Tarn, Angela A Hwang, Daniel P Ferris, Sean P Sherman, Courtney R Thomas, Jie Lu, April D Pyle, Jeffrey I Zink, Fuyuhiko Tamanoi.   

Abstract

The exocytosis of phosphonate modified mesoporous silica nanoparticles (P-MSNs) is demonstrated and lysosomal exocytosis is identified as the mechanism responsible for this event. Regulation of P-MSN exocytosis can be achieved by inhibiting or accelerating lysosomal exocytosis. Slowing down P-MSN exocytosis enhances the drug delivery effect of CPT-loaded P-MSNs by improving cell killing.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 23152124      PMCID： PMC3767416          DOI： 10.1002/smll.201201811

Source DB:  PubMed          Journal:  Small        ISSN： 1613-6810            Impact factor:   13.281


  55 in total

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Authors:  Rolando E Yanes; Fuyuhiko Tamanoi
Journal:  Ther Deliv       Date:  2012-03

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3.  Mesoporous silica nanoparticle based controlled release, drug delivery, and biosensor systems.

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Review 4.  Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers.

Authors:  Igor I Slowing; Juan L Vivero-Escoto; Chia-Wen Wu; Victor S-Y Lin
Journal:  Adv Drug Deliv Rev       Date:  2008-04-10       Impact factor: 15.470

5.  Circulation of cholesterol between lysosomes and the plasma membrane.

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Journal:  J Biol Chem       Date:  1998-07-24       Impact factor: 5.157

6.  Mesoporous silica nanoparticles facilitate delivery of siRNA to shutdown signaling pathways in mammalian cells.

Authors:  Christopher Hom; Jie Lu; Monty Liong; Hanzhi Luo; Zongxi Li; Jeffrey I Zink; Fuyuhiko Tamanoi
Journal:  Small       Date:  2010-06-06       Impact factor: 13.281

7.  Synthesis of biomolecule-modified mesoporous silica nanoparticles for targeted hydrophobic drug delivery to cancer cells.

Authors:  Daniel P Ferris; Jie Lu; Chris Gothard; Rolando Yanes; Courtney R Thomas; John-Carl Olsen; J Fraser Stoddart; Fuyuhiko Tamanoi; Jeffrey I Zink
Journal:  Small       Date:  2011-05-19       Impact factor: 13.281

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Authors:  Huan Meng; Min Xue; Tian Xia; Zhaoxia Ji; Derrick Y Tarn; Jeffrey I Zink; Andre E Nel
Journal:  ACS Nano       Date:  2011-04-27       Impact factor: 15.881

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Journal:  J Cell Biol       Date:  2000-03-20       Impact factor: 10.539

10.  Lysosomes behave as Ca2+-regulated exocytic vesicles in fibroblasts and epithelial cells.

Authors:  A Rodríguez; P Webster; J Ortego; N W Andrews
Journal:  J Cell Biol       Date:  1997-04-07       Impact factor: 10.539
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Review 3.  Crosstalk of Nanosystems Induced Extracellular Vesicles as Promising Tools in Biomedical Applications.

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4.  Alveolar epithelial cell processing of nanoparticles activates autophagy and lysosomal exocytosis.

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Review 5.  Protocells: Modular Mesoporous Silica Nanoparticle-Supported Lipid Bilayers for Drug Delivery.

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Review 6.  Cellular uptake of nanoparticles: journey inside the cell.

Authors:  Shahed Behzadi; Vahid Serpooshan; Wei Tao; Majd A Hamaly; Mahmoud Y Alkawareek; Erik C Dreaden; Dennis Brown; Alaaldin M Alkilany; Omid C Farokhzad; Morteza Mahmoudi
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7.  A reversible light-operated nanovalve on mesoporous silica nanoparticles.

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8.  The role of surface functionality in nanoparticle exocytosis.

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