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Literature DB >> 20667736

Descriptive no more: the dawn of high-throughput microscopy.

Vassilis Roukos¹, Tom Misteli, Christine K Schmidt.

Abstract

The next revolution in microscopy is upon us: it is High-Throughput Imaging (HTI). In HTI large numbers of images from many samples are acquired and analyzed. This has become possible due to a confluence of dramatic progress in microscope engineering, enabling efficient image collection, and the availability of high computing power for data analysis. Combining HTI with genome-wide RNA interference (RNAi)-based gene knockdown technology offers a powerful approach for unbiased discovery of cellular mechanisms. Published by Elsevier Ltd.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Year: 2010 PMID： 20667736 PMCID： PMC2933271 DOI： 10.1016/j.tcb.2010.06.008

Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808

24 in total

1. Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes.

Authors: Beate Neumann; Thomas Walter; Jean-Karim Hériché; Jutta Bulkescher; Holger Erfle; Christian Conrad; Phill Rogers; Ina Poser; Michael Held; Urban Liebel; Cihan Cetin; Frank Sieckmann; Gregoire Pau; Rolf Kabbe; Annelie Wünsche; Venkata Satagopam; Michael H A Schmitz; Catherine Chapuis; Daniel W Gerlich; Reinhard Schneider; Roland Eils; Wolfgang Huber; Jan-Michael Peters; Anthony A Hyman; Richard Durbin; Rainer Pepperkok; Jan Ellenberg
Journal: Nature Date: 2010-04-01 Impact factor: 49.962

2. Systematic analysis of human protein complexes identifies chromosome segregation proteins.

Authors: James R A Hutchins; Yusuke Toyoda; Björn Hegemann; Ina Poser; Jean-Karim Hériché; Martina M Sykora; Martina Augsburg; Otto Hudecz; Bettina A Buschhorn; Jutta Bulkescher; Christian Conrad; David Comartin; Alexander Schleiffer; Mihail Sarov; Andrei Pozniakovsky; Mikolaj Michal Slabicki; Siegfried Schloissnig; Ines Steinmacher; Marit Leuschner; Andrea Ssykor; Steffen Lawo; Laurence Pelletier; Holger Stark; Kim Nasmyth; Jan Ellenberg; Richard Durbin; Frank Buchholz; Karl Mechtler; Anthony A Hyman; Jan-Michael Peters
Journal: Science Date: 2010-04-01 Impact factor: 47.728

3. Green fluorescent protein as a marker for gene expression.

Authors: M Chalfie; Y Tu; G Euskirchen; W W Ward; D C Prasher
Journal: Science Date: 1994-02-11 Impact factor: 47.728

4. Considerations on a laser-scanning-microscope with high resolution and depth of field.

Authors: C Cremer; T Cremer
Journal: Microsc Acta Date: 1978-09

Review 5. MicroRNA control of signal transduction.

Authors: Masafumi Inui; Graziano Martello; Stefano Piccolo
Journal: Nat Rev Mol Cell Biol Date: 2010-03-10 Impact factor: 94.444

6. Metadata matters: access to image data in the real world.

Authors: Melissa Linkert; Curtis T Rueden; Chris Allan; Jean-Marie Burel; Will Moore; Andrew Patterson; Brian Loranger; Josh Moore; Carlos Neves; Donald Macdonald; Aleksandra Tarkowska; Caitlin Sticco; Emma Hill; Mike Rossner; Kevin W Eliceiri; Jason R Swedlow
Journal: J Cell Biol Date: 2010-05-31 Impact factor: 10.539

Review 2. Chromatin in the nuclear landscape.

Authors: D B Beck; R Bonasio; S Kaneko; G Li; G Li; R Margueron; H Oda; K Sarma; R J Sims; J Son; P Trojer; D Reinberg
Journal: Cold Spring Harb Symp Quant Biol Date: 2011-04-18

2 in total

Descriptive no more: the dawn of high-throughput microscopy.

1. Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes.

2. Systematic analysis of human protein complexes identifies chromosome segregation proteins.

3. Green fluorescent protein as a marker for gene expression.

4. Considerations on a laser-scanning-microscope with high resolution and depth of field.

Review 5. MicroRNA control of signal transduction.

6. Metadata matters: access to image data in the real world.

Review 7. Automated microscopy for high-content RNAi screening.

8. A genome-wide genetic screen for host factors required for hepatitis C virus propagation.

9. Actin antibody: the specific visualization of actin filaments in non-muscle cells.

10. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.

1. Ranked retrieval of segmented nuclei for objective assessment of cancer gene repositioning.

Review 2. Chromatin in the nuclear landscape.