Literature DB >> 20660643

Targeting DNA double-strand breaks with TAL effector nucleases.

Michelle Christian1, Tomas Cermak, Erin L Doyle, Clarice Schmidt, Feng Zhang, Aaron Hummel, Adam J Bogdanove, Daniel F Voytas.   

Abstract

Engineered nucleases that cleave specific DNA sequences in vivo are valuable reagents for targeted mutagenesis. Here we report a new class of sequence-specific nucleases created by fusing transcription activator-like effectors (TALEs) to the catalytic domain of the FokI endonuclease. Both native and custom TALE-nuclease fusions direct DNA double-strand breaks to specific, targeted sites.

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Year:  2010        PMID： 20660643      PMCID： PMC2942870          DOI： 10.1534/genetics.110.120717

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  20 in total

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Authors:  M Elrod-Erickson; M A Rould; L Nekludova; C O Pabo
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4.  FokI dimerization is required for DNA cleavage.

Authors:  J Bitinaite; D A Wah; A K Aggarwal; I Schildkraut
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-01       Impact factor: 11.205

5.  Synergy between adjacent zinc fingers in sequence-specific DNA recognition.

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