Literature DB >> 20660206

The 3' untranslated region of the Andes hantavirus small mRNA functionally replaces the poly(A) tail and stimulates cap-dependent translation initiation from the viral mRNA.

Jorge Vera-Otarola1, Ricardo Soto-Rifo, Emiliano P Ricci, Théophile Ohlmann, Jean-Luc Darlix, Marcelo López-Lastra.   

Abstract

In the process of translation of eukaryotic mRNAs, the 5' cap and the 3' poly(A) tail interact synergistically to stimulate protein synthesis. Unlike its cellular counterparts, the small mRNA (SmRNA) of Andes hantavirus (ANDV), a member of the Bunyaviridae, lacks a 3' poly(A) tail. Here we report that the 3' untranslated region (3'UTR) of the ANDV SmRNA functionally replaces a poly(A) tail and synergistically stimulates cap-dependent translation initiation from the viral mRNA. Stimulation of translation by the 3'UTR of the ANDV SmRNA was found to be independent of viral proteins and of host poly(A)-binding protein.

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Year:  2010        PMID： 20660206      PMCID： PMC2937818          DOI： 10.1128/JVI.01270-10

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  50 in total

Review 1.  The cap-to-tail guide to mRNA turnover.

Authors:  C J Wilusz; M Wormington; S W Peltz
Journal:  Nat Rev Mol Cell Biol       Date:  2001-04       Impact factor: 94.444

Review 2.  Replication of hantaviruses.

Authors:  C B Jonsson; C S Schmaljohn
Journal:  Curr Top Microbiol Immunol       Date:  2001       Impact factor: 4.291

Review 3.  The ends of the affair: capping and polyadenylation.

Authors:  A J Shatkin; J L Manley
Journal:  Nat Struct Biol       Date:  2000-10

Review 4.  The poly(A) tail of mRNAs: bodyguard in eukaryotes, scavenger in bacteria.

Authors:  Marc Dreyfus; Philippe Régnier
Journal:  Cell       Date:  2002-11-27       Impact factor: 41.582

5.  Eukaryotic initiation factor 4G-poly(A) binding protein interaction is required for poly(A) tail-mediated stimulation of picornavirus internal ribosome entry segment-driven translation but not for X-mediated stimulation of hepatitis C virus translation.

Authors:  Y M Michel; A M Borman; S Paulous; K M Kean
Journal:  Mol Cell Biol       Date:  2001-07       Impact factor: 4.272

6.  The Bunyamwera virus nonstructural protein NSs inhibits viral RNA synthesis in a minireplicon system.

Authors:  F Weber; E F Dunn; A Bridgen; R M Elliott
Journal:  Virology       Date:  2001-03-01       Impact factor: 3.616

7.  Poly(A)-binding protein interaction with elF4G stimulates picornavirus IRES-dependent translation.

Authors:  Y V Svitkin; H Imataka; K Khaleghpour; A Kahvejian; H D Liebig; N Sonenberg
Journal:  RNA       Date:  2001-12       Impact factor: 4.942

8.  Picornavirus IRESes and the poly(A) tail jointly promote cap-independent translation in a mammalian cell-free system.

Authors:  G Bergamini; T Preiss; M W Hentze
Journal:  RNA       Date:  2000-12       Impact factor: 4.942

Review 9.  The mechanism of eukaryotic translation initiation and principles of its regulation.

Authors:  Richard J Jackson; Christopher U T Hellen; Tatyana V Pestova
Journal:  Nat Rev Mol Cell Biol       Date:  2010-02       Impact factor: 94.444

10.  Complete nucleotide sequence of a Chilean hantavirus.

Authors:  John D Meissner; Joan E Rowe; Monica K Borucki; Stephen C St Jeor
Journal:  Virus Res       Date:  2002-10       Impact factor: 3.303
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  6 in total

1.  Ribosomal protein S19-binding domain provides insights into hantavirus nucleocapsid protein-mediated translation initiation mechanism.

Authors:  Safder S Ganaie; Absarul Haque; Erdong Cheng; Tania S Bonny; Nilshad N Salim; Mohammad A Mir
Journal:  Biochem J       Date:  2014-11-15       Impact factor: 3.857

2.  The Andes hantavirus NSs protein is expressed from the viral small mRNA by a leaky scanning mechanism.

Authors:  Jorge Vera-Otarola; Loretto Solis; Ricardo Soto-Rifo; Emiliano P Ricci; Karla Pino; Nicole D Tischler; Théophile Ohlmann; Jean-Luc Darlix; Marcelo López-Lastra
Journal:  J Virol       Date:  2011-12-07       Impact factor: 5.103

3.  The mammalian orthoreovirus bicistronic M3 mRNA initiates translation using a 5' end-dependent, scanning mechanism that does not require interaction of 5'-3' untranslated regions.

Authors:  Vidya Sagar; Kenneth E Murray
Journal:  Virus Res       Date:  2014-01-30       Impact factor: 3.303

4.  Ribosome binding to a 5' translational enhancer is altered in the presence of the 3' untranslated region in cap-independent translation of turnip crinkle virus.

Authors:  Vera A Stupina; Xuefeng Yuan; Arturas Meskauskas; Jonathan D Dinman; Anne E Simon
Journal:  J Virol       Date:  2011-03-09       Impact factor: 5.103

5.  General Molecular Strategy for Development of Arenavirus Live-Attenuated Vaccines.

Authors:  Masaharu Iwasaki; Nhi Ngo; Beatrice Cubitt; John R Teijaro; Juan C de la Torre
Journal:  J Virol       Date:  2015-09-23       Impact factor: 5.103

Review 6.  Who Regulates Whom? An Overview of RNA Granules and Viral Infections.

Authors:  Natalia Poblete-Durán; Yara Prades-Pérez; Jorge Vera-Otarola; Ricardo Soto-Rifo; Fernando Valiente-Echeverría
Journal:  Viruses       Date:  2016-06-28       Impact factor: 5.048
  6 in total

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