Literature DB >> 22156529

The Andes hantavirus NSs protein is expressed from the viral small mRNA by a leaky scanning mechanism.

Jorge Vera-Otarola1, Loretto Solis, Ricardo Soto-Rifo, Emiliano P Ricci, Karla Pino, Nicole D Tischler, Théophile Ohlmann, Jean-Luc Darlix, Marcelo López-Lastra.   

Abstract

The small mRNA (SmRNA) of all Bunyaviridae encodes the nucleocapsid (N) protein. In 4 out of 5 genera in the Bunyaviridae, the smRNA encodes an additional nonstructural protein denominated NSs. In this study, we show that Andes hantavirus (ANDV) SmRNA encodes an NSs protein. Data show that the NSs protein is expressed in the context of an ANDV infection. Additionally, our results suggest that translation initiation from the NSs initiation codon is mediated by ribosomal subunits that have bypassed the upstream N protein initiation codon through a leaky scanning mechanism.

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Year:  2011        PMID： 22156529      PMCID： PMC3302399          DOI： 10.1128/JVI.06223-11

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  56 in total

1.  The control of globin synthesis in rabbit reticulocytes.

Authors:  T Hunt
Journal:  Ann N Y Acad Sci       Date:  1974-11-29       Impact factor: 5.691

2.  Characterization of cross-reactive and serotype-specific epitopes on the nucleocapsid proteins of hantaviruses.

Authors:  Nicole D Tischler; Mario Rosemblatt; Pablo D T Valenzuela
Journal:  Virus Res       Date:  2008-03-14       Impact factor: 3.303

3.  Andes virus antigens are shed in urine of patients with acute hantavirus cardiopulmonary syndrome.

Authors:  Paula Godoy; Delphine Marsac; Elias Stefas; Pablo Ferrer; Nicole D Tischler; Karla Pino; Pablo Ramdohr; Pablo Vial; Pablo D T Valenzuela; Marcela Ferrés; Francisco Veas; Marcelo López-Lastra
Journal:  J Virol       Date:  2009-03-11       Impact factor: 5.103

Review 4.  Hantavirus pulmonary syndrome in Latin America.

Authors:  Noemi Pini
Journal:  Curr Opin Infect Dis       Date:  2004-10       Impact factor: 4.915

5.  Viruses in the Anopheles A, Anopheles B, and Tete serogroups in the Orthobunyavirus genus (family Bunyaviridae) do not encode an NSs protein.

Authors:  Maizan Mohamed; Angela McLees; Richard M Elliott
Journal:  J Virol       Date:  2009-05-13       Impact factor: 5.103

6.  Analysis of natural variants of the hepatitis C virus internal ribosome entry site reveals that primary sequence plays a key role in cap-independent translation.

Authors:  María Inés Barría; Angel González; Jorge Vera-Otarola; Ursula León; Valeska Vollrath; Delphine Marsac; Octavio Monasterio; Tomás Pérez-Acle; Alejandro Soza; Marcelo López-Lastra
Journal:  Nucleic Acids Res       Date:  2008-12-23       Impact factor: 16.971

7.  Tula hantavirus isolate with the full-length ORF for nonstructural protein NSs survives for more consequent passages in interferon-competent cells than the isolate having truncated NSs ORF.

Authors:  Kirsi M Jääskeläinen; Angelina Plyusnina; Ake Lundkvist; Antti Vaheri; Alexander Plyusnin
Journal:  Virol J       Date:  2008-01-11       Impact factor: 4.099

8.  A SAP30 complex inhibits IFN-beta expression in Rift Valley fever virus infected cells.

Authors:  Nicolas Le May; Zeyni Mansuroglu; Psylvia Léger; Thibaut Josse; Guillaume Blot; Agnès Billecocq; Ramon Flick; Yves Jacob; Eliette Bonnefoy; Michèle Bouloy
Journal:  PLoS Pathog       Date:  2008-01       Impact factor: 6.823

9.  Severe acute respiratory syndrome coronavirus accessory protein 9b is a virion-associated protein.

Authors:  Ke Xu; Bo-Jian Zheng; Rong Zeng; Wei Lu; Yong-Ping Lin; Liang Xue; Li Li; Lei-Lei Yang; Chen Xu; Jie Dai; Fei Wang; Qing Li; Qing-Xi Dong; Rui-Fu Yang; Jia-Rui Wu; Bing Sun
Journal:  Virology       Date:  2009-04-25       Impact factor: 3.616

10.  Translational control of the subgenomic RNAs of severe acute respiratory syndrome coronavirus.

Authors:  Yaling Yang; Snawar Hussain; Hao Wang; Min Ke; Deyin Guo
Journal:  Virus Genes       Date:  2009-04-12       Impact factor: 2.332
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  30 in total

1.  The Andes Orthohantavirus NSs Protein Antagonizes the Type I Interferon Response by Inhibiting MAVS Signaling.

Authors:  Jorge Vera-Otarola; Loretto Solis; Fernando Lowy; Valeria Olguín; Jenniffer Angulo; Karla Pino; Nicole D Tischler; Carola Otth; Paula Padula; Marcelo López-Lastra
Journal:  J Virol       Date:  2020-06-16       Impact factor: 5.103

2.  Cellular cholesterol abundance regulates potassium accumulation within endosomes and is an important determinant in bunyavirus entry.

Authors:  Frank W Charlton; Samantha Hover; Jack Fuller; Roger Hewson; Juan Fontana; John N Barr; Jamel Mankouri
Journal:  J Biol Chem       Date:  2019-02-25       Impact factor: 5.157

3.  Diversity and distribution of hantaviruses in South America.

Authors:  Cadhla Firth; Rafal Tokarz; Darlene B Simith; Marcio R T Nunes; Meera Bhat; Elizabeth S T Rosa; Daniele B A Medeiros; Gustavo Palacios; Pedro F C Vasconcelos; W Ian Lipkin
Journal:  J Virol       Date:  2012-10-10       Impact factor: 5.103

Review 4.  The nucleocapsid protein of hantaviruses: much more than a genome-wrapping protein.

Authors:  Monika Reuter; Detlev H Krüger
Journal:  Virus Genes       Date:  2017-11-20       Impact factor: 2.332

5.  Field vole-associated Traemmersee hantavirus from Germany represents a novel hantavirus species.

Authors:  Kathrin Jeske; Melanie Hiltbrunner; Stephan Drewes; René Ryll; Matthias Wenk; Aliona Špakova; Rasa Petraitytė-Burneikienė; Gerald Heckel; Rainer G Ulrich
Journal:  Virus Genes       Date:  2019-10-01       Impact factor: 2.332

6.  Development of a minigenome system for Andes virus, a New World hantavirus.

Authors:  Kyle S Brown; Hideki Ebihara; Heinz Feldmann
Journal:  Arch Virol       Date:  2012-07-21       Impact factor: 2.574

7.  The internal ribosome entry site of the Dengue virus mRNA is active when cap-dependent translation initiation is inhibited.

Authors:  Leandro Fernández-García; Jenniffer Angulo; Hade Ramos; Aldo Barrera; Karla Pino; Jorge Vera-Otarola; Marcelo López-Lastra
Journal:  J Virol       Date:  2020-12-09       Impact factor: 5.103

8.  Discovery of a unique novel clade of mosquito-associated bunyaviruses.

Authors:  Marco Marklewitz; Florian Zirkel; Innocent B Rwego; Hanna Heidemann; Pascal Trippner; Andreas Kurth; René Kallies; Thomas Briese; W Ian Lipkin; Christian Drosten; Thomas R Gillespie; Sandra Junglen
Journal:  J Virol       Date:  2013-09-25       Impact factor: 5.103

9.  Differential lymphocyte and antibody responses in deer mice infected with Sin Nombre hantavirus or Andes hantavirus.

Authors:  Tony Schountz; Sandra Quackenbush; Joel Rovnak; Elaine Haddock; William C Black; Heinz Feldmann; Joseph Prescott
Journal:  J Virol       Date:  2014-05-14       Impact factor: 5.103

10.  The 5' untranslated region of the human T-cell lymphotropic virus type 1 mRNA enables cap-independent translation initiation.

Authors:  Eduardo Olivares; Dori M Landry; C Joaquín Cáceres; Karla Pino; Federico Rossi; Camilo Navarrete; Juan Pablo Huidobro-Toro; Sunnie R Thompson; Marcelo López-Lastra
Journal:  J Virol       Date:  2014-03-12       Impact factor: 5.103
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