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Literature DB >> 20657920

Enthalpically driven peptide stabilization by protective osmolytes.

Abstract

We determined the added enthalpic and entropic contributions of protective osmolytes to the folding of a model peptide into its native beta-hairpin state. In contrast to entropically driven steric "crowding", this study shows that sugars and polyols can act as protective osmolytes by primarily diminishing the unfavourable enthalpic contribution to folding.

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Year: 2010 PMID： 20657920 DOI： 10.1039/c0cc01763a

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

17 in total

1. Analysis of the size dependence of macromolecular crowding shows that smaller is better.

Authors: Kim A Sharp
Journal: Proc Natl Acad Sci U S A Date: 2015-06-15 Impact factor: 11.205

Review 2. Soft interactions and crowding.

Authors: Mohona Sarkar; Conggang Li; Gary J Pielak
Journal: Biophys Rev Date: 2013-02-21

3. Molecular mechanism for the preferential exclusion of TMAO from protein surfaces.

Authors: Deepak R Canchi; Pruthvi Jayasimha; Donald C Rau; George I Makhatadze; Angel E Garcia
Journal: J Phys Chem B Date: 2012-10-01 Impact factor: 2.991

4. Separating chemical and excluded volume interactions of polyethylene glycols with native proteins: Comparison with PEG effects on DNA helix formation.

Authors: Irina A Shkel; D B Knowles; M Thomas Record
Journal: Biopolymers Date: 2015-09 Impact factor: 2.505

5. Cosolute and Crowding Effects on a Side-By-Side Protein Dimer.

Authors: Alex J Guseman; Gary J Pielak
Journal: Biochemistry Date: 2017-02-09 Impact factor: 3.162

6. Chemical Interactions of Polyethylene Glycols (PEGs) and Glycerol with Protein Functional Groups: Applications to Effects of PEG and Glycerol on Protein Processes.

Authors: D B Knowles; Irina A Shkel; Noel M Phan; Matt Sternke; Emily Lingeman; Xian Cheng; Lixue Cheng; Kevin O'Connor; M Thomas Record
Journal: Biochemistry Date: 2015-05-22 Impact factor: 3.162

Enthalpically driven peptide stabilization by protective osmolytes.

1. Analysis of the size dependence of macromolecular crowding shows that smaller is better.

Review 2. Soft interactions and crowding.

3. Molecular mechanism for the preferential exclusion of TMAO from protein surfaces.

4. Separating chemical and excluded volume interactions of polyethylene glycols with native proteins: Comparison with PEG effects on DNA helix formation.

5. Cosolute and Crowding Effects on a Side-By-Side Protein Dimer.

6. Chemical Interactions of Polyethylene Glycols (PEGs) and Glycerol with Protein Functional Groups: Applications to Effects of PEG and Glycerol on Protein Processes.

7. Insights into the disparate action of osmolytes and macromolecular crowders on amyloid formation.

8. Folding propensity of intrinsically disordered proteins by osmotic stress.

9. Computational analysis of C-reactive protein for assessment of molecular dynamics and interaction properties.

10. Crowder-Induced Conformational Ensemble Shift in Escherichia coli Prolyl-tRNA Synthetase.