OBJECTIVE: The aim of this preliminary report was to assess glucose metabolism in the cervical spine of patients with chronic compressive myelopathy by using FDG PET. METHODS: Ten patients with monosegmental chronic degenerative stenosis and local cord compression of the upper/middle cervical spine with signs of myelopathy on MRI and 10 control patients without known cervical abnormalities were investigated by FDG PET. Maximum standardised uptake values (SUV(max)) were measured at all levels of the cervical spine (C1-C7). RESULTS: While the controls showed the typical pattern of homogeneous linear FDG uptake along the entire cervical cord, the patients with chronic compressive myelopathy had a normal glucose utilisation only above the level of stenosis and a significant decrease in FDG uptake below their individual level of cord compression. This may be caused by atrophy of anterior grey horn cells and the loss of glucose-consuming neurons below the level of cord compression. CONCLUSION: FDG PET of the spine of patients with chronic compressive myelopathy may be helpful to determine the stage and severity of cervical myelopathy.
OBJECTIVE: The aim of this preliminary report was to assess glucose metabolism in the cervical spine of patients with chronic compressive myelopathy by using FDG PET. METHODS: Ten patients with monosegmental chronic degenerative stenosis and local cord compression of the upper/middle cervical spine with signs of myelopathy on MRI and 10 control patients without known cervical abnormalities were investigated by FDG PET. Maximum standardised uptake values (SUV(max)) were measured at all levels of the cervical spine (C1-C7). RESULTS: While the controls showed the typical pattern of homogeneous linear FDG uptake along the entire cervical cord, the patients with chronic compressive myelopathy had a normal glucose utilisation only above the level of stenosis and a significant decrease in FDG uptake below their individual level of cord compression. This may be caused by atrophy of anterior grey horn cells and the loss of glucose-consuming neurons below the level of cord compression. CONCLUSION:FDG PET of the spine of patients with chronic compressive myelopathy may be helpful to determine the stage and severity of cervical myelopathy.
Authors: Ramona E von Leden; Reed G Selwyn; Shalini Jaiswal; Colin M Wilson; Guzal Khayrullina; Kimberly R Byrnes Journal: Neurosci Lett Date: 2016-04-12 Impact factor: 3.046
Authors: Allan R Martin; Lindsay Tetreault; Aria Nouri; Armin Curt; Patrick Freund; Vafa Rahimi-Movaghar; Jefferson R Wilson; Michael G Fehlings; Brian K Kwon; James S Harrop; Benjamin M Davies; Mark R N Kotter; James D Guest; Bizhan Aarabi; Shekar N Kurpad Journal: Global Spine J Date: 2021-11-19