OBJECTIVES: Evidence has suggested that the serotonin transporter (SERT) plays a role in the pathogenesis of alcohol dependence, anxiety and depression and that polymorphisms of the serotonin-transporter-linked promoter region (5-HTTLPR) may influence the SERT. This study evaluated the differences in SERT availability between healthy controls and alcoholic patients and the impact of 5-HTTLPR polymorphisms on SERT availability. METHODS: Eleven healthy controls and 28 alcoholic patients were recruited. SERT availability was measured in vivo with single photon emission computed tomography and (123)I-labelled 2-((2-((dimethyl-amino)methyl)phenyl)thio)-5-iodophenylamine in the midbrain, thalamus and striatum. Each subject was genotyped for the 5-HTTLPR polymorphism. RESULTS: Compared to healthy controls, there was a significantly lower availability of SERT in the midbrain among patients with pure alcohol dependence (pure ALC). Of patients with anxiety, depression and alcohol dependence (ANX/DEPALC), the carriers of one L(A) allele showed a significantly higher availability of SERT in the striatum compared to non-L(A) carriers. After Bonferroni correction, these significances vanished. There were no significant differences in SERT availability between controls and ANX/DEP ALC. CONCLUSIONS: The results suggest that pure alcoholics may have lower SERT availability in the midbrain; the 5HTTLPR polymorphism may influence SERT availability in ANX/DEP ALC. These findings may serve as a springboard for future large-scale studies.
OBJECTIVES: Evidence has suggested that the serotonin transporter (SERT) plays a role in the pathogenesis of alcohol dependence, anxiety and depression and that polymorphisms of the serotonin-transporter-linked promoter region (5-HTTLPR) may influence the SERT. This study evaluated the differences in SERT availability between healthy controls and alcoholicpatients and the impact of 5-HTTLPR polymorphisms on SERT availability. METHODS: Eleven healthy controls and 28 alcoholicpatients were recruited. SERT availability was measured in vivo with single photon emission computed tomography and (123)I-labelled 2-((2-((dimethyl-amino)methyl)phenyl)thio)-5-iodophenylamine in the midbrain, thalamus and striatum. Each subject was genotyped for the 5-HTTLPR polymorphism. RESULTS: Compared to healthy controls, there was a significantly lower availability of SERT in the midbrain among patients with pure alcohol dependence (pure ALC). Of patients with anxiety, depression and alcohol dependence (ANX/DEPALC), the carriers of one L(A) allele showed a significantly higher availability of SERT in the striatum compared to non-L(A) carriers. After Bonferroni correction, these significances vanished. There were no significant differences in SERT availability between controls and ANX/DEP ALC. CONCLUSIONS: The results suggest that pure alcoholics may have lower SERT availability in the midbrain; the 5HTTLPR polymorphism may influence SERT availability in ANX/DEP ALC. These findings may serve as a springboard for future large-scale studies.
Authors: Marco Calabrò; Laura Mandelli; Concetta Crisafulli; Stefano Porcelli; Diego Albani; Antonis Politis; George N Papadimitriou; Marco Di Nicola; Luigi Janiri; Roberto Colombo; Giovanni Martinotti; Antonello Bellomo; Eduard Vieta; Stefano Bonassi; Alessandra Frustaci; Giuseppe Ducci; Stefano Landi; Stefania Boccia; Alessandro Serretti Journal: Mol Biol Rep Date: 2019-10-08 Impact factor: 2.316
Authors: Anastasia Kourikou; George P Karamanolis; George D Dimitriadis; Konstantinos Triantafyllou Journal: World J Gastroenterol Date: 2015-07-07 Impact factor: 5.742