Literature DB >> 27173413

Alcohol Dependence and Harmful Use of Alcohol.

Anil Batra1, Christian A Müller, Karl Mann, Andreas Heinz.   

Abstract

BACKGROUND: In Germany today, there are more than 1.8 million persons who are dependent on alcohol, and 1.6 million persons whose use of alcohol is harmful. The many complications of alcohol use are both mental and physical-in particular, gastrointestinal and neurological. Yet more than 80% of persons whose alcohol use is problematic still receive no treatment for their harmful use or dependence, despite contact with the health-care system.
METHODS: This article is a selective review of the pertinent literature, including guidelines, meta-analyses, and Cochrane Reviews.
RESULTS: The treatment is divided into an early interventional and motivational phase, qualified withdrawal, long-term cessation therapy, and a stabilization phase. Pharmacotherapy with acamprosate or naltrexone increases the rate of abstinence (number needed to treat: 12 and 20, respectively). If a patient lacks the motivation to abstain from alcohol entirely, reduced consumption can be agreed upon as a goal of treatment. 85% of patients relapse if no further treatment is given after initial detoxification.
CONCLUSION: What is needed in routine medical practice is practical diagnostic evaluation followed by individually tailored treatment, based on the severity of the condition, the development of the patient's motivation to be treated, and the local treatment options (e.g., outpatient addiction clinics, counseling centers, or day clinics).

Entities:  

Mesh:

Year:  2016        PMID: 27173413      PMCID: PMC4873678          DOI: 10.3238/arztebl.2016.0301

Source DB:  PubMed          Journal:  Dtsch Arztebl Int        ISSN: 1866-0452            Impact factor:   5.594


  40 in total

1.  PHosphatidylethanol (PEth) concentrations in blood are correlated to reported alcohol intake in alcohol-dependent patients.

Authors:  Steina Aradottir; Gulber Asanovska; Stefan Gjerss; Per Hansson; Christer Alling
Journal:  Alcohol Alcohol       Date:  2006-04-19       Impact factor: 2.826

Review 2.  Acamprosate for the treatment of alcohol dependence.

Authors:  Lisa A Boothby; Paul L Doering
Journal:  Clin Ther       Date:  2005-06       Impact factor: 3.393

3.  Follow-up of 180 alcoholic patients for up to 7 years after outpatient treatment: impact of alcohol deterrents on outcome.

Authors:  Henning Krampe; Sabina Stawicki; Thilo Wagner; Claudia Bartels; Carlotta Aust; Eckart Rüther; Wolfgang Poser; Hannelore Ehrenreich
Journal:  Alcohol Clin Exp Res       Date:  2006-01       Impact factor: 3.455

4.  Long-term efficacy, tolerability and safety of nalmefene as-needed in patients with alcohol dependence: A 1-year, randomised controlled study.

Authors:  Wim van den Brink; Per Sørensen; Lars Torup; Karl Mann; Antoni Gual
Journal:  J Psychopharmacol       Date:  2014-03-26       Impact factor: 4.153

Review 5.  [Psychosocial Treatment of Addictive Disorders--An Overview of Psychotherapeutic Options and their Efficacy].

Authors:  M Walter; K M Dürsteler; S A Petitjean; G A Wiesbeck; S Euler; D Sollberger; U E Lang; M Vogel
Journal:  Fortschr Neurol Psychiatr       Date:  2015-04-20       Impact factor: 0.752

6.  Qualitatively and quantitatively evaluating harm-reduction goal setting among chronically homeless individuals with alcohol dependence.

Authors:  Susan E Collins; Véronique S Grazioli; Nicole I Torres; Emily M Taylor; Connor B Jones; Gail E Hoffman; Laura Haelsig; Mengdan D Zhu; Alyssa S Hatsukami; Molly J Koker; Patrick Herndon; Shawna M Greenleaf; Parker E Dean
Journal:  Addict Behav       Date:  2015-02-08       Impact factor: 3.913

7.  The long-term course of alcoholism, 5, 10 and 16 years after treatment.

Authors:  Karl Mann; Dorothee R Schäfer; Gerhard Längle; Klaus Ackermann; Bernhard Croissant
Journal:  Addiction       Date:  2005-06       Impact factor: 6.526

Review 8.  Biochemical markers of alcoholism.

Authors:  Minna L Hannuksela; Marja K Liisanantti; Antti E T Nissinen; Markku J Savolainen
Journal:  Clin Chem Lab Med       Date:  2007       Impact factor: 3.694

9.  Screening for At-Risk Drinking in a Population Reporting Symptoms of Depression: A Validation of the AUDIT, AUDIT-C, and AUDIT-3.

Authors:  Jonna Levola; Mauri Aalto
Journal:  Alcohol Clin Exp Res       Date:  2015-06-08       Impact factor: 3.455

10.  All cause mortality and the case for age specific alcohol consumption guidelines: pooled analyses of up to 10 population based cohorts.

Authors:  Craig S Knott; Ngaire Coombs; Emmanuel Stamatakis; Jane P Biddulph
Journal:  BMJ       Date:  2015-02-10
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  17 in total

1.  Preventing Binge Drinking in Adolescents.

Authors:  Reiner Hanewinkel; Samuel Tomczyk; Michaela Goecke; Barbara Isensee
Journal:  Dtsch Arztebl Int       Date:  2017-04-21       Impact factor: 5.594

Review 2.  [Alcohol and the heart : Anecdotes on the history of a checkered relationship].

Authors:  B Lüderitz
Journal:  Herz       Date:  2016-09       Impact factor: 1.443

3.  Binge Drinking: Current Diagnostic and Therapeutic Issues.

Authors:  Benjamin Rolland; Mickaël Naassila
Journal:  CNS Drugs       Date:  2017-03       Impact factor: 5.749

4.  Promoter Specific Methylation of SSTR4 is Associated With Alcohol Dependence in Han Chinese Males.

Authors:  Rongrong Zhao; Huihui Shi; Jiajun Yin; Zhen Sun; Yahui Xu
Journal:  Front Genet       Date:  2022-06-09       Impact factor: 4.772

5.  Synaptic effects of IL-1β and CRF in the central amygdala after protracted alcohol abstinence in male rhesus macaques.

Authors:  Reesha R Patel; Florence P Varodayan; Melissa A Herman; Vanessa Jimenez; Rebecca Agnore; Lina Gao; Michal Bajo; Verginia C Cuzon Carlson; Nicole A Walter; Suzanne S Fei; Kathleen A Grant; Marisa Roberto
Journal:  Neuropsychopharmacology       Date:  2021-11-26       Impact factor: 8.294

6.  Readmission Rates and Causes Within The First Six Months After Discharge in Patients with Alcohol Addiction.

Authors:  Bahadır Geniş; Behçet Coşar; Zehra Arikan
Journal:  Noro Psikiyatr Ars       Date:  2020-10-11       Impact factor: 1.339

7.  Nalmefene attenuates neural alcohol cue-reactivity in the ventral striatum and subjective alcohol craving in patients with alcohol use disorder.

Authors:  Damian Karl; J Malte Bumb; Patrick Bach; Christina Dinter; Anne Koopmann; Derik Hermann; Karl Mann; Falk Kiefer; Sabine Vollstädt-Klein
Journal:  Psychopharmacology (Berl)       Date:  2021-04-12       Impact factor: 4.530

Review 8.  Alcoholic cardiomyopathy : The result of dosage and individual predisposition.

Authors:  B Maisch
Journal:  Herz       Date:  2016-09       Impact factor: 1.443

9.  Classical blood biomarkers identify patients with higher risk for relapse 6 months after alcohol withdrawal treatment.

Authors:  Florian J Raabe; Elias Wagner; Eva Hoch; Gabriele Koller; Judith Weiser; Sarah Brechtel; David Popovic; Kristina Adorjan; Oliver Pogarell
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2020-07-05       Impact factor: 5.270

10.  Case Report: Intensive Inpatient Neurorehabilitation Achieves Sustained Real-World Benefits in Severe Alcohol-Related Wernicke-Korsakoff Syndrome: A Case Study With 7-Years Follow-Up.

Authors:  Mareike Schrader; Stephan Bamborschke; Ute Lenk; Annette Sterr
Journal:  Front Psychol       Date:  2021-06-16
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