Literature DB >> 20636392

Histamine receptors and cancer pharmacology.

Vanina A Medina1, Elena S Rivera.   

Abstract

Considerable evidence has been collected indicating that histamine can modulate proliferation of different normal and malignant cells. High histamine biosynthesis and content together with histamine receptors have been reported in different human neoplasias including melanoma, colon and breast cancer, as well as in experimental tumours in which histamine has been postulated to behave as an important paracrine and autocrine regulator of proliferation. The discovery of the human histamine H(4) receptor in different tissues has contributed to our understanding of histamine role in numerous physiological and pathological conditions revealing novel functions for histamine and opening new perspectives in histamine pharmacology research. In the present review we aimed to briefly summarize current knowledge on histamine and histamine receptor involvement in cancer before focusing on some recent evidence supporting the novel role of histamine H(4) receptor in cancer progression representing a promising molecular target and avenue for cancer drug development.
© 2010 The Authors. British Journal of Pharmacology © 2010 The British Pharmacological Society.

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Year:  2010        PMID： 20636392      PMCID： PMC2992892          DOI： 10.1111/j.1476-5381.2010.00961.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  108 in total

1.  Histamine regulates pancreatic carcinoma cell growth through H3 and H4 receptors.

Authors:  G P Cricco; N A Mohamad; L A Sambuco; F Genre; M Croci; A S Gutiérrez; V A Medina; R M Bergoc; E S Rivera; G A Martín
Journal:  Inflamm Res       Date:  2008       Impact factor: 4.575

Review 2.  Molecular and biochemical pharmacology of the histamine H4 receptor.

Authors:  Rob Leurs; Paul L Chazot; Fiona C Shenton; Herman D Lim; Iwan J P de Esch
Journal:  Br J Pharmacol       Date:  2009-05       Impact factor: 8.739

3.  Histamine levels in whole peripheral blood from women with ductal breast cancer: a pilot study.

Authors:  K Kyriakidis; E Zampeli; E Tiligada
Journal:  Inflamm Res       Date:  2009-04       Impact factor: 4.575

4.  Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor.

Authors:  Richard M van Rijn; André van Marle; Paul L Chazot; Ellen Langemeijer; Yongjun Qin; Fiona C Shenton; Herman D Lim; Obbe P Zuiderveld; Kamonchanok Sansuk; Michel Dy; Martine J Smit; Cornelis P Tensen; Remko A Bakker; Rob Leurs
Journal:  Biochem J       Date:  2008-08-15       Impact factor: 3.857

5.  cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.

Authors:  Huaqing Liu; Robert J Altenbach; Tracy L Carr; Prasant Chandran; Gin C Hsieh; La Geisha R Lewis; Arlene M Manelli; Ivan Milicic; Kennan C Marsh; Thomas R Miller; Marina I Strakhova; Timothy A Vortherms; Brian D Wakefield; Jill M Wetter; David G Witte; Prisca Honore; Timothy A Esbenshade; Jorge D Brioni; Marlon D Cowart
Journal:  J Med Chem       Date:  2008-11-27       Impact factor: 7.446

6.  Involvement of hydrogen peroxide in histamine-induced modulation of WM35 human malignant melanoma cell proliferation.

Authors:  Vanina A Medina; Noelia A Massari; Graciela P Cricco; Gabriela A Martín; Rosa M Bergoc; Elena S Rivera
Journal:  Free Radic Biol Med       Date:  2009-03-12       Impact factor: 7.376

7.  Autoregulation of McA-RH7777 hepatoma cell proliferation by histamine H3 receptors.

Authors:  E Davenas; A Rouleau; S Morisset; J M Arrang
Journal:  J Pharmacol Exp Ther       Date:  2008-05-12       Impact factor: 4.030

8.  Phenylalanine 169 in the second extracellular loop of the human histamine H4 receptor is responsible for the difference in agonist binding between human and mouse H4 receptors.

Authors:  Herman D Lim; Aldo Jongejan; Remko A Bakker; Eric Haaksma; Iwan J P de Esch; Rob Leurs
Journal:  J Pharmacol Exp Ther       Date:  2008-07-17       Impact factor: 4.030

9.  Pharmacological characterization of the new histamine H4 receptor agonist VUF 8430.

Authors:  Herman D Lim; Maristella Adami; Elena Guaita; Thomas Werfel; Rogier A Smits; Iwan J P de Esch; Remko A Bakker; Ralf Gutzmer; Gabriella Coruzzi; Rob Leurs
Journal:  Br J Pharmacol       Date:  2009-05       Impact factor: 8.739

10.  The role of histamine in human mammary carcinogenesis: H3 and H4 receptors as potential therapeutic targets for breast cancer treatment.

Authors:  Vanina Medina; Máximo Croci; Ernesto Crescenti; Nora Mohamad; Francisca Sanchez-Jiménez; Noelia Massari; Mariel Nuñez; Graciela Cricco; Gabriela Martin; Rosa Bergoc; Elena Rivera
Journal:  Cancer Biol Ther       Date:  2007-10-08       Impact factor: 4.742
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  63 in total

Review 1.  Histamine H₄ receptors in the gastrointestinal tract.

Authors:  A Deiteren; J G De Man; P A Pelckmans; B Y De Winter
Journal:  Br J Pharmacol       Date:  2015-01-12       Impact factor: 8.739

2.  Histamine restricts cancer: nothing to sneeze at.

Authors:  Brian Ruffell; Lisa M Coussens
Journal:  Nat Med       Date:  2011-01       Impact factor: 53.440

3.  Histamine reduces susceptibility to natural killer cells via down-regulation of NKG2D ligands on human monocytic leukaemia THP-1 cells.

Authors:  Yasuhiro Nagai; Yukinori Tanaka; Toshinobu Kuroishi; Ryutaro Sato; Yasuo Endo; Shunji Sugawara
Journal:  Immunology       Date:  2012-05       Impact factor: 7.397

4.  Antihistamine use and immunoglobulin E levels in glioma risk and prognosis.

Authors:  E Susan Amirian; Deborah Marquez-Do; Melissa L Bondy; Michael E Scheurer
Journal:  Cancer Epidemiol       Date:  2013-08-30       Impact factor: 2.984

5.  Histamine stimulates the proliferation of small and large cholangiocytes by activation of both IP3/Ca2+ and cAMP-dependent signaling mechanisms.

Authors:  Heather L Francis; Sharon Demorrow; Antonio Franchitto; Julie K Venter; Romina A Mancinelli; Mellanie A White; Fanyin Meng; Yoshiyuki Ueno; Guido Carpino; Anastasia Renzi; Kimberly K Baker; Hannah E Shine; Taylor C Francis; Eugenio Gaudio; Gianfranco D Alpini; Paolo Onori
Journal:  Lab Invest       Date:  2011-11-07       Impact factor: 5.662

6.  Histamine and histamine receptor regulation of gastrointestinal cancers.

Authors:  Lindsey Kennedy; Kyle Hodges; Fanyin Meng; Gianfranco Alpini; Heather Francis
Journal:  Transl Gastrointest Cancer       Date:  2012-10

7.  Histamine modulates salivary secretion and diminishes the progression of periodontal disease in rat experimental periodontitis.

Authors:  Juan P Prestifilippo; Eliana Carabajal; Máximo Croci; Javier Fernández-Solari; Elena S Rivera; Juan C Elverdin; Vanina A Medina
Journal:  Inflamm Res       Date:  2012-01-20       Impact factor: 4.575

8.  Synthetic FXR agonist GW4064 is a modulator of multiple G protein-coupled receptors.

Authors:  Nidhi Singh; Manisha Yadav; Abhishek Kumar Singh; Harish Kumar; Shailendra Kumar Dhar Dwivedi; Jay Sharan Mishra; Anagha Gurjar; Amit Manhas; Sharat Chandra; Prem Narayan Yadav; Kumaravelu Jagavelu; Mohammad Imran Siddiqi; Arun Kumar Trivedi; Naibedya Chattopadhyay; Sabyasachi Sanyal
Journal:  Mol Endocrinol       Date:  2014-03-05

9.  Enhancement of ionizing radiation response by histamine in vitro and in vivo in human breast cancer.

Authors:  Diego J Martinel Lamas; Jorge E Cortina; Clara Ventura; Helena A Sterle; Eduardo Valli; Karina B Balestrasse; Horacio Blanco; Graciela A Cremaschi; Elena S Rivera; Vanina A Medina
Journal:  Cancer Biol Ther       Date:  2015       Impact factor: 4.742

10.  Therapeutic potential of histamine H₄ receptor agonists in triple-negative human breast cancer experimental model.

Authors:  Diego J Martinel Lamas; Maximo Croci; Eliana Carabajal; Ernesto J V Crescenti; Lorena Sambuco; Noelia A Massari; Rosa M Bergoc; Elena S Rivera; Vanina A Medina
Journal:  Br J Pharmacol       Date:  2013-09       Impact factor: 8.739
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