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Literature DB >> 19413568

Molecular and biochemical pharmacology of the histamine H4 receptor.

Rob Leurs¹, Paul L Chazot, Fiona C Shenton, Herman D Lim, Iwan J P de Esch.

Abstract

The elucidation of the human genome has had a major impact on histamine receptor research. The identification of the human H4 receptor by several groups has been instrumental for a new appreciation of the role of histamine in the modulation of immune function. In this review, we summarize the historical developments and the molecular and biochemical pharmacology of the H4 receptor.

Entities: Chemical Gene Species

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Year: 2009 PMID： 19413568 PMCID： PMC2697796 DOI： 10.1111/j.1476-5381.2009.00250.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

75 in total

1. Histamine H3 and H4 receptors are expressed on distinct endocrine cell types in the rat fundic mucosa.

Authors: G Morini; G Becchi; F C Shenton; P L Chazot; D Grandi
Journal: Inflamm Res Date: 2008 Impact factor: 4.575

Review 2. The histamine H3 receptor: an attractive target for the treatment of cognitive disorders.

Authors: T A Esbenshade; K E Browman; R S Bitner; M Strakhova; M D Cowart; J D Brioni
Journal: Br J Pharmacol Date: 2008-05-12 Impact factor: 8.739

3. Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor.

Authors: Richard M van Rijn; André van Marle; Paul L Chazot; Ellen Langemeijer; Yongjun Qin; Fiona C Shenton; Herman D Lim; Obbe P Zuiderveld; Kamonchanok Sansuk; Michel Dy; Martine J Smit; Cornelis P Tensen; Remko A Bakker; Rob Leurs
Journal: Biochem J Date: 2008-08-15 Impact factor: 3.857

4. Histamine H4 receptors modulate dendritic cell migration through skin--immunomodulatory role of histamine.

Authors: W Bäumer; S Wendorff; R Gutzmer; T Werfel; D Dijkstra; P Chazot; H Stark; M Kietzmann
Journal: Allergy Date: 2008-10 Impact factor: 13.146

5. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties.

Authors: Robin L Thurmond; Pragnya J Desai; Paul J Dunford; Wai-Ping Fung-Leung; Claudia L Hofstra; Wen Jiang; Steven Nguyen; Jason P Riley; Siquan Sun; Kacy N Williams; James P Edwards; Lars Karlsson
Journal: J Pharmacol Exp Ther Date: 2004-01-13 Impact factor: 4.030

6. Human inflammatory dendritic epidermal cells express a functional histamine H4 receptor.

Authors: Dorothea Dijkstra; Holger Stark; Paul L Chazot; Fiona C Shenton; Rob Leurs; Thomas Werfel; Ralf Gutzmer
Journal: J Invest Dermatol Date: 2008-01-31 Impact factor: 8.551

7. Structure of a beta1-adrenergic G-protein-coupled receptor.

Authors: Tony Warne; Maria J Serrano-Vega; Jillian G Baker; Rouslan Moukhametzianov; Patricia C Edwards; Richard Henderson; Andrew G W Leslie; Christopher G Tate; Gebhard F X Schertler
Journal: Nature Date: 2008-06-25 Impact factor: 49.962

8. Cloning and pharmacological characterization of the dog histamine H4 receptor.

Authors: Wen Jiang; Herman D Lim; Mai Zhang; Pragnya Desai; Heng Dai; Patricia M Colling; Rob Leurs; Robin L Thurmond
Journal: Eur J Pharmacol Date: 2008-07-02 Impact factor: 4.432

9. Histamine induces cytoskeletal changes in human eosinophils via the H(4) receptor.

Authors: Karen F Buckland; Timothy J Williams; Dolores M Conroy
Journal: Br J Pharmacol Date: 2003-10-06 Impact factor: 8.739

10. Delineation of agonist binding to the human histamine H4 receptor using mutational analysis, homology modeling, and ab initio calculations.

Authors: Aldo Jongejan; Herman D Lim; Rogier A Smits; Iwan J P de Esch; Eric Haaksma; Rob Leurs
Journal: J Chem Inf Model Date: 2008-06-14 Impact factor: 4.956

41 in total

Molecular and biochemical pharmacology of the histamine H4 receptor.

1. Histamine H3 and H4 receptors are expressed on distinct endocrine cell types in the rat fundic mucosa.

Review 2. The histamine H3 receptor: an attractive target for the treatment of cognitive disorders.

3. Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor.

4. Histamine H4 receptors modulate dendritic cell migration through skin--immunomodulatory role of histamine.

5. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties.

6. Human inflammatory dendritic epidermal cells express a functional histamine H4 receptor.

7. Structure of a beta1-adrenergic G-protein-coupled receptor.

8. Cloning and pharmacological characterization of the dog histamine H4 receptor.

9. Histamine induces cytoskeletal changes in human eosinophils via the H(4) receptor.

10. Delineation of agonist binding to the human histamine H4 receptor using mutational analysis, homology modeling, and ab initio calculations.

Review 1. Histamine H₄ receptors in the gastrointestinal tract.

2. Commercially available antibodies against human and murine histamine H₄-receptor lack specificity.

3. Histamine modulates γδ-T lymphocyte migration and cytotoxicity, via Gi and Gs protein-coupled signalling pathways.

4. Advances in histamine pharmacology reveal new drug targets.

Review 5. Current and emerging options for the drug treatment of narcolepsy.

Review 6. Eosinophils and mast cells as therapeutic targets in pediatric functional dyspepsia.

7. GPCR theme editorial.

8. A search for functional histamine H4 receptors in the human, guinea pig and mouse brain.

9. Therapeutic potential of histamine H₄ receptor agonists in triple-negative human breast cancer experimental model.

10. Detailed analysis of biased histamine H₄ receptor signalling by JNJ 7777120 analogues.