CONTEXT: Low 25-hydroxyvitamin D [25(OH)D] and high PTH may contribute to increased mortality risk in older adults. OBJECTIVE: The aim of the study was to test the association between 25(OH)D, PTH, and mortality in older men. DESIGN AND SETTING: The prospective Osteoporotic Fractures in Men (MrOS) study was conducted at six U.S. clinical centers. PARTICIPANTS: We studied community-dwelling men at least 65 yr old (n = 1490). MAIN OUTCOME MEASURE: Multivariate-adjusted proportional hazards models estimated the hazard ratio (HR) for mortality; cause of death was classified as cancer, cardiovascular, and other by central review of death certificates. RESULTS: During 7.3 yr of follow-up, 330 (22.2%) participants died: 97 from cancer, 110 from cardiovascular disease, and 106 from other causes. The adjusted HR per sd decrease in 25(OH)D for all-cause mortality was 1.01 (95% CI, 0.89, 1.14); no association between 25(OH)D and cardiovascular or other-cause mortality was seen. Unexpectedly, lower 25(OH)D levels were modestly associated with a decreased risk of cancer mortality (adjusted HR per sd decrease, 0.80; 95% CI, 0.64, 0.99). Analyzing 25(OH)D as a categorical variable did not alter these results. Higher PTH levels (log-transformed) were associated with an increased risk of all-cause mortality (adjusted HR per sd increase, 1.15; 95% CI, 1.03, 1.29) and cardiovascular mortality (adjusted HR per sd increase in PTH, 1.21; 95% CI, 1.00, 1.45). CONCLUSIONS: In contrast to previous studies, lower 25(OH)D levels were not associated with an increased risk of all-cause or cause-specific mortality in older men. Higher PTH levels were associated with a modest increase in mortality risk.
CONTEXT: Low 25-hydroxyvitamin D [25(OH)D] and high PTH may contribute to increased mortality risk in older adults. OBJECTIVE: The aim of the study was to test the association between 25(OH)D, PTH, and mortality in older men. DESIGN AND SETTING: The prospective Osteoporotic Fractures in Men (MrOS) study was conducted at six U.S. clinical centers. PARTICIPANTS: We studied community-dwelling men at least 65 yr old (n = 1490). MAIN OUTCOME MEASURE: Multivariate-adjusted proportional hazards models estimated the hazard ratio (HR) for mortality; cause of death was classified as cancer, cardiovascular, and other by central review of death certificates. RESULTS: During 7.3 yr of follow-up, 330 (22.2%) participants died: 97 from cancer, 110 from cardiovascular disease, and 106 from other causes. The adjusted HR per sd decrease in 25(OH)D for all-cause mortality was 1.01 (95% CI, 0.89, 1.14); no association between 25(OH)D and cardiovascular or other-cause mortality was seen. Unexpectedly, lower 25(OH)D levels were modestly associated with a decreased risk of cancer mortality (adjusted HR per sd decrease, 0.80; 95% CI, 0.64, 0.99). Analyzing 25(OH)D as a categorical variable did not alter these results. Higher PTH levels (log-transformed) were associated with an increased risk of all-cause mortality (adjusted HR per sd increase, 1.15; 95% CI, 1.03, 1.29) and cardiovascular mortality (adjusted HR per sd increase in PTH, 1.21; 95% CI, 1.00, 1.45). CONCLUSIONS: In contrast to previous studies, lower 25(OH)D levels were not associated with an increased risk of all-cause or cause-specific mortality in older men. Higher PTH levels were associated with a modest increase in mortality risk.
Authors: Eric Orwoll; Carrie M Nielson; Lynn M Marshall; Lori Lambert; Kathleen F Holton; Andrew R Hoffman; Elizabeth Barrett-Connor; James M Shikany; Tien Dam; Jane A Cauley Journal: J Clin Endocrinol Metab Date: 2009-01-27 Impact factor: 5.958
Authors: Mark J Bolland; Catherine J Bacon; Anne M Horne; Barbara H Mason; Ruth W Ames; Tom Km Wang; Andrew B Grey; Greg D Gamble; Ian R Reid Journal: Am J Clin Nutr Date: 2009-11-11 Impact factor: 7.045
Authors: Harald Dobnig; Stefan Pilz; Hubert Scharnagl; Wilfried Renner; Ursula Seelhorst; Britta Wellnitz; Jürgen Kinkeldei; Bernhard O Boehm; Gisela Weihrauch; Winfried Maerz Journal: Arch Intern Med Date: 2008-06-23
Authors: D Michal Freedman; Barbara Fuhrman; Barry I Graubard; Shih-Chen Chang Journal: Cancer Epidemiol Biomarkers Prev Date: 2009-01 Impact factor: 4.254
Authors: Tommy Ahlström; Emil Hagström; Anders Larsson; Claes Rudberg; Lars Lind; Per Hellman Journal: Clin Endocrinol (Oxf) Date: 2009-02-25 Impact factor: 3.478
Authors: R D Semba; D K Houston; S Bandinelli; K Sun; A Cherubini; A R Cappola; J M Guralnik; L Ferrucci Journal: Eur J Clin Nutr Date: 2009-12-02 Impact factor: 4.016
Authors: H Johansson; A Odén; J Kanis; E McCloskey; M Lorentzon; Ö Ljunggren; M K Karlsson; P M Thorsby; Å Tivesten; E Barrett-Connor; C Ohlsson; D Mellström Journal: Osteoporos Int Date: 2011-10-19 Impact factor: 4.507
Authors: Clifford J Rosen; John S Adams; Daniel D Bikle; Dennis M Black; Marie B Demay; JoAnn E Manson; M Hassan Murad; Christopher S Kovacs Journal: Endocr Rev Date: 2012-05-17 Impact factor: 19.871
Authors: Cedric F Garland; June Jiwon Kim; Sharif Burgette Mohr; Edward Doerr Gorham; William B Grant; Edward L Giovannucci; Leo Baggerly; Heather Hofflich; Joe Wesley Ramsdell; Kenneth Zeng; Robert P Heaney Journal: Am J Public Health Date: 2014-06-12 Impact factor: 9.308
Authors: Lu Wang; Yiqing Song; Joann E Manson; Stefan Pilz; Winfried März; Karl Michaëlsson; Annamari Lundqvist; Simerjot K Jassal; Elizabeth Barrett-Connor; Cuilin Zhang; Charles B Eaton; Heidi T May; Jeffrey L Anderson; Howard D Sesso Journal: Circ Cardiovasc Qual Outcomes Date: 2012-11-13
Authors: A J van Ballegooijen; M Visser; M F Cotch; A E Arai; M Garcia; T B Harris; L J Launer; G Eiríksdóttir; V Gudnason; I A Brouwer Journal: J Clin Endocrinol Metab Date: 2013-04-12 Impact factor: 5.958
Authors: Cortney Bosworth; Michael C Sachs; Daniel Duprez; Andrew N Hoofnagle; Joachim H Ix; David R Jacobs; Carmen A Peralta; David S Siscovick; Bryan Kestenbaum; Ian H de Boer Journal: Clin Endocrinol (Oxf) Date: 2013-05-20 Impact factor: 3.478
Authors: Gotaro Kojima; Christina L Bell; Randi Chen; G Webster Ross; Robert D Abbott; Lenore Launer; Felix Lui; Kamal Masaki Journal: J Am Coll Nutr Date: 2014 Impact factor: 3.169
Authors: Lisa B Signorello; Xijing Han; Qiuyin Cai; Sarah S Cohen; Elizabeth L Cope; Wei Zheng; William J Blot Journal: Am J Epidemiol Date: 2012-11-01 Impact factor: 4.897