PURPOSE: To investigate the association between serum 25-hydroxyvitamin D [25(OH)D] concentration, a marker of vitamin D status, and risk of all-cause and cardiovascular mortality in a general older population with relatively low average serum 25(OH)D concentrations. METHODS: The study population included 552 men and 584 women aged 53-73 years who were free of CVD and cancer at baseline in 1998-2001 from the prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study. Deaths were ascertained by a computer linkage to the national cause of death register. All deaths that occurred from the study entry to December 31, 2008, were included. Cox proportional hazards regression models were used to analyze the association between serum 25(OH)D and risk of death. RESULTS: The mean serum 25(OH)D concentration was 43.7 nmol/L (SD 17.8), with a strong seasonal variation. During the average follow-up of 9.1 years, 87 participants died, 35 from cardiovascular disease (CVD). After multivariable-adjustments, the hazard ratios (HR) for all cause death in the tertiles of serum 25(OH)D were 1, 1.68 (95% CI: 0.92, 3.07) and 2.06 (95% CI: 1.12, 3.80), p for trend = 0.02. CONCLUSIONS: Our study supports the accumulating evidence from epidemiological studies that vitamin D deficiency is associated with increased risk of death. Large-scale primary prevention trials with vitamin D supplementation are warranted.
PURPOSE: To investigate the association between serum 25-hydroxyvitamin D [25(OH)D] concentration, a marker of vitamin D status, and risk of all-cause and cardiovascular mortality in a general older population with relatively low average serum 25(OH)D concentrations. METHODS: The study population included 552 men and 584 women aged 53-73 years who were free of CVD and cancer at baseline in 1998-2001 from the prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study. Deaths were ascertained by a computer linkage to the national cause of death register. All deaths that occurred from the study entry to December 31, 2008, were included. Cox proportional hazards regression models were used to analyze the association between serum 25(OH)D and risk of death. RESULTS: The mean serum 25(OH)D concentration was 43.7 nmol/L (SD 17.8), with a strong seasonal variation. During the average follow-up of 9.1 years, 87 participants died, 35 from cardiovascular disease (CVD). After multivariable-adjustments, the hazard ratios (HR) for all cause death in the tertiles of serum 25(OH)D were 1, 1.68 (95% CI: 0.92, 3.07) and 2.06 (95% CI: 1.12, 3.80), p for trend = 0.02. CONCLUSIONS: Our study supports the accumulating evidence from epidemiological studies that vitamin D deficiency is associated with increased risk of death. Large-scale primary prevention trials with vitamin D supplementation are warranted.
Authors: Jyrki K Virtanen; Sari Voutilainen; Tiina H Rissanen; Jaakko Mursu; Tomi-Pekka Tuomainen; Maarit J Korhonen; Veli-Pekka Valkonen; Kari Seppänen; Jari A Laukkanen; Jukka T Salonen Journal: Arterioscler Thromb Vasc Biol Date: 2004-11-11 Impact factor: 8.311
Authors: Anastassios G Pittas; Mei Chung; Thomas Trikalinos; Joanna Mitri; Michael Brendel; Kamal Patel; Alice H Lichtenstein; Joseph Lau; Ethan M Balk Journal: Ann Intern Med Date: 2010-03-02 Impact factor: 25.391
Authors: Ilkka Laaksi; Juha-Petri Ruohola; Pentti Tuohimaa; Anssi Auvinen; Riina Haataja; Harri Pihlajamäki; Timo Ylikomi Journal: Am J Clin Nutr Date: 2007-09 Impact factor: 7.045
Authors: Annamari Kilkkinen; Paul Knekt; Antti Aro; Harri Rissanen; Jukka Marniemi; Markku Heliövaara; Olli Impivaara; Antti Reunanen Journal: Am J Epidemiol Date: 2009-09-17 Impact factor: 4.897
Authors: Richard D Semba; Denise K Houston; Luigi Ferrucci; Anne R Cappola; Kai Sun; Jack M Guralnik; Linda P Fried Journal: Nutr Res Date: 2009-08 Impact factor: 3.315
Authors: M Vidgren; J K Virtanen; T Tolmunen; T Nurmi; T-P Tuomainen; S Voutilainen; A Ruusunen Journal: J Nutr Health Aging Date: 2018 Impact factor: 4.075
Authors: Cedric F Garland; June Jiwon Kim; Sharif Burgette Mohr; Edward Doerr Gorham; William B Grant; Edward L Giovannucci; Leo Baggerly; Heather Hofflich; Joe Wesley Ramsdell; Kenneth Zeng; Robert P Heaney Journal: Am J Public Health Date: 2014-06-12 Impact factor: 9.308
Authors: M Kyla Shea; Denise K Houston; Janet A Tooze; Cralen C Davis; Mary Ann Johnson; Dorothy B Hausman; Jane A Cauley; Douglas C Bauer; Frances Tylavsky; Tamara B Harris; Stephen B Kritchevsky Journal: J Am Geriatr Soc Date: 2011-06-13 Impact factor: 5.562