PURPOSE: To determine the relationship between fish and shellfish consumption and age-related macular degeneration (AMD) status in the Salisbury Eye Evaluation (SEE) Study participants. DESIGN: A cross-sectional study of dietary and ophthalmologic data. PARTICIPANTS: A random sample of 2520 Salisbury, Maryland, residents aged 65 to 84 years. METHODS: A food frequency questionnaire was used to estimate weekly fish/shellfish consumption for each participant. Age-related macular degeneration status was determined from fundus photographs obtained at baseline and graded by 2 masked readers for drusen size, retinal pigment epithelium abnormalities, geographic atrophy (GA), and choroidal neovascularization (CNV). The association between weekly fish/shellfish intake and risk of AMD was investigated using logistic regression while adjusting for risk factors and correlation between eyes. MAIN OUTCOME MEASURES: Status of AMD. RESULTS: The distribution of weekly fish/shellfish consumption was not different between specific AMD categories compared with controls (P = 0.6, 0.7, and 0.7 for large drusen, pigment abnormalities, and advanced AMD compared with controls, respectively). Those with advanced AMD (CNV or GA) were significantly less likely to consume fish/shellfish high in omega-3 fatty acids (odds ratio 0.4; confidence interval, 0.2-0.8). There was no relationship of AMD with intake of crab and oysters combined, each of which has high levels of zinc. CONCLUSIONS: These data support a protective effect of fish/shellfish intake against advanced AMD.
PURPOSE: To determine the relationship between fish and shellfish consumption and age-related macular degeneration (AMD) status in the Salisbury Eye Evaluation (SEE) Study participants. DESIGN: A cross-sectional study of dietary and ophthalmologic data. PARTICIPANTS: A random sample of 2520 Salisbury, Maryland, residents aged 65 to 84 years. METHODS: A food frequency questionnaire was used to estimate weekly fish/shellfish consumption for each participant. Age-related macular degeneration status was determined from fundus photographs obtained at baseline and graded by 2 masked readers for drusen size, retinal pigment epithelium abnormalities, geographic atrophy (GA), and choroidal neovascularization (CNV). The association between weekly fish/shellfish intake and risk of AMD was investigated using logistic regression while adjusting for risk factors and correlation between eyes. MAIN OUTCOME MEASURES: Status of AMD. RESULTS: The distribution of weekly fish/shellfish consumption was not different between specific AMD categories compared with controls (P = 0.6, 0.7, and 0.7 for large drusen, pigment abnormalities, and advanced AMD compared with controls, respectively). Those with advanced AMD (CNV or GA) were significantly less likely to consume fish/shellfish high in omega-3 fatty acids (odds ratio 0.4; confidence interval, 0.2-0.8). There was no relationship of AMD with intake of crab and oysters combined, each of which has high levels of zinc. CONCLUSIONS: These data support a protective effect of fish/shellfish intake against advanced AMD.
Authors: S K West; B Munoz; G S Rubin; O D Schein; K Bandeen-Roche; S Zeger; S German; L P Fried Journal: Invest Ophthalmol Vis Sci Date: 1997-01 Impact factor: 4.799
Authors: Cristina Augood; Usha Chakravarthy; Ian Young; Jesus Vioque; Paulus T V M de Jong; Graham Bentham; Mati Rahu; Johan Seland; Gisele Soubrane; Laura Tomazzoli; Fotis Topouzis; Johannes R Vingerling; Astrid E Fletcher Journal: Am J Clin Nutr Date: 2008-08 Impact factor: 7.045
Authors: John Paul Sangiovanni; Elvira Agrón; A Dhananjayan Meleth; George F Reed; Robert D Sperduto; Traci E Clemons; Emily Y Chew Journal: Am J Clin Nutr Date: 2009-10-07 Impact factor: 7.045
Authors: John Paul SanGiovanni; Emily Y Chew; Elvira Agrón; Traci E Clemons; Frederick L Ferris; Gary Gensler; Anne S Lindblad; Roy C Milton; Johanna M Seddon; Ronald Klein; Robert D Sperduto Journal: Arch Ophthalmol Date: 2008-09
Authors: John Paul SanGiovanni; Emily Y Chew; Traci E Clemons; Matthew D Davis; Frederick L Ferris; Gary R Gensler; Natalie Kurinij; Anne S Lindblad; Roy C Milton; Johanna M Seddon; Robert D Sperduto Journal: Arch Ophthalmol Date: 2007-05
Authors: Emily Y Chew; Traci E Clemons; John Paul Sangiovanni; Ronald P Danis; Frederick L Ferris; Michael J Elman; Andrew N Antoszyk; Alan J Ruby; David Orth; Susan B Bressler; Gary E Fish; George Baker Hubbard; Michael L Klein; Suresh R Chandra; Barbara A Blodi; Amitha Domalpally; Thomas Friberg; Wai T Wong; Philip J Rosenfeld; Elvira Agrón; Cynthia A Toth; Paul S Bernstein; Robert D Sperduto Journal: JAMA Ophthalmol Date: 2014-02 Impact factor: 7.389
Authors: Andrea Elmore; William S Harris; Lina Mu; William E Brady; Kathleen M Hovey; Julie A Mares; Mark A Espeland; Mary N Haan; Amy E Millen Journal: Eur J Nutr Date: 2022-01-06 Impact factor: 5.614
Authors: Emily Y Chew; Traci Clemons; John Paul SanGiovanni; Ronald Danis; Amitha Domalpally; Wendy McBee; Robert Sperduto; Frederick L Ferris Journal: Ophthalmology Date: 2012-07-26 Impact factor: 12.079