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Literature DB >> 22342272

Sterculic acid antagonizes 7-ketocholesterol-mediated inflammation and inhibits choroidal neovascularization.

Jiahn-Dar Huang¹, Juan Amaral, Jung Wha Lee, Ignacio M Larrayoz, Ignacio R Rodriguez.

Abstract

Sterculic acid is a cyclopropene fatty acid with numerous biological activities. In this study we demonstrate that sterculic acid is a potent inhibitor of endoplasmic reticulum (ER) stress and related inflammation caused by 7-ketocholesterol (7KCh). 7KCh is a highly toxic oxysterol suspected in the pathogenesis of various age-related diseases such as atherosclerosis, Alzheimer's disease and age-related macular degeneration. Sterculic acid demonstrated to be 5-10 times more effective than other anti-inflammatory fatty acids at inhibiting 7KCh-mediated inflammatory responses in cultured cells. In vivo, sterculic acid was effective at inhibiting the formation of choroidal neovascularization (CNV) in the laser-injury rat model. Our data suggests that sterculic acid may be useful in treating CNV in certain forms of age-related macular degeneration. Published by Elsevier B.V.

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Year: 2012 PMID： 22342272 PMCID： PMC3307944 DOI： 10.1016/j.bbalip.2012.01.013

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

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