Literature DB >> 20622837

Inhibitors for E3 ubiquitin ligases.

John R Lydeard, J Wade Harper.   

Abstract

Mesh：

Substances：

Year:  2010        PMID： 20622837     DOI： 10.1038/nbt0710-682

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN： 1087-0156            Impact factor:   54.908


× No keyword cloud information.
  8 in total

1.  Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication.

Authors:  P Nash; X Tang; S Orlicky; Q Chen; F B Gertler; M D Mendenhall; F Sicheri; T Pawson; M Tyers
Journal:  Nature       Date:  2001-11-29       Impact factor: 49.962

Review 2.  Drug discovery in the ubiquitin-proteasome system.

Authors:  Grzegorz Nalepa; Mark Rolfe; J Wade Harper
Journal:  Nat Rev Drug Discov       Date:  2006-07       Impact factor: 84.694

3.  An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase.

Authors:  Stephen Orlicky; Xiaojing Tang; Victor Neduva; Nadine Elowe; Eric D Brown; Frank Sicheri; Mike Tyers
Journal:  Nat Biotechnol       Date:  2010-06-27       Impact factor: 54.908

Review 4.  Function and regulation of cullin-RING ubiquitin ligases.

Authors:  Matthew D Petroski; Raymond J Deshaies
Journal:  Nat Rev Mol Cell Biol       Date:  2005-01       Impact factor: 94.444

5.  Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases.

Authors:  Bing Hao; Stephanie Oehlmann; Mathew E Sowa; J Wade Harper; Nikola P Pavletich
Journal:  Mol Cell       Date:  2007-04-13       Impact factor: 17.970

Review 6.  FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation.

Authors:  Markus Welcker; Bruce E Clurman
Journal:  Nat Rev Cancer       Date:  2008-02       Impact factor: 60.716

7.  An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer.

Authors:  Teresa A Soucy; Peter G Smith; Michael A Milhollen; Allison J Berger; James M Gavin; Sharmila Adhikari; James E Brownell; Kristine E Burke; David P Cardin; Stephen Critchley; Courtney A Cullis; Amanda Doucette; James J Garnsey; Jeffrey L Gaulin; Rachel E Gershman; Anna R Lublinsky; Alice McDonald; Hirotake Mizutani; Usha Narayanan; Edward J Olhava; Stephane Peluso; Mansoureh Rezaei; Michael D Sintchak; Tina Talreja; Michael P Thomas; Tary Traore; Stepan Vyskocil; Gabriel S Weatherhead; Jie Yu; Julie Zhang; Lawrence R Dick; Christopher F Claiborne; Mark Rolfe; Joseph B Bolen; Steven P Langston
Journal:  Nature       Date:  2009-04-09       Impact factor: 49.962

8.  Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase.

Authors:  Mariam Aghajan; Nao Jonai; Karin Flick; Fei Fu; Manlin Luo; Xiaolu Cai; Ikram Ouni; Nathan Pierce; Xiaobo Tang; Brett Lomenick; Robert Damoiseaux; Rui Hao; Pierre M Del Moral; Rati Verma; Ying Li; Cheng Li; Kendall N Houk; Michael E Jung; Ning Zheng; Lan Huang; Raymond J Deshaies; Peter Kaiser; Jing Huang
Journal:  Nat Biotechnol       Date:  2010-06-27       Impact factor: 54.908
  8 in total
  10 in total

1.  Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.

Authors:  Jared T Hammill; Deepak Bhasin; Daniel C Scott; Jaeki Min; Yizhe Chen; Yan Lu; Lei Yang; Ho Shin Kim; Michele C Connelly; Courtney Hammill; Gloria Holbrook; Cynthia Jeffries; Bhuvanesh Singh; Brenda A Schulman; R Kiplin Guy
Journal:  J Med Chem       Date:  2018-03-26       Impact factor: 7.446

2.  IKKε-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.

Authors:  Alicia Y Zhou; Rhine R Shen; Eejung Kim; Ying J Lock; Ming Xu; Zhijian J Chen; William C Hahn
Journal:  Cell Rep       Date:  2013-02-28       Impact factor: 9.423

3.  Serine phosphorylation is critical for the activation of ubiquitin-specific protease 1 and its interaction with WD40-repeat protein UAF1.

Authors:  Mark A Villamil; Qin Liang; Junjun Chen; Yong Seok Choi; Shuyu Hou; Kelvin H Lee; Zhihao Zhuang
Journal:  Biochemistry       Date:  2012-11-01       Impact factor: 3.162

4.  Investigation of the intermolecular recognition mechanism between the E3 ubiquitin ligase Keap1 and substrate based on multiple substrates analysis.

Authors:  Zheng-Yu Jiang; Li-Li Xu; Meng-Chen Lu; Yang Pan; Hao-Ze Huang; Xiao-Jin Zhang; Hao-Peng Sun; Qi-Dong You
Journal:  J Comput Aided Mol Des       Date:  2014-10-10       Impact factor: 3.686

Review 5.  Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives.

Authors:  Federico Andreoli; Arménio Jorge Moura Barbosa; Marco Daniele Parenti; Alberto Del Rio
Journal:  Curr Pharm Des       Date:  2013       Impact factor: 3.310

Review 6.  Small-molecule control of intracellular protein levels through modulation of the ubiquitin proteasome system.

Authors:  Dennis L Buckley; Craig M Crews
Journal:  Angew Chem Int Ed Engl       Date:  2014-01-23       Impact factor: 16.823

7.  c-CBL E3 ubiquitin ligase is overexpressed in cutaneous T-cell lymphoma: its inhibition promotes activation-induced cell death.

Authors:  Jianqiang Wu; Katrin A Salva; Gary S Wood
Journal:  J Invest Dermatol       Date:  2014-08-14       Impact factor: 8.551

8.  Surface charge of Merkel cell polyomavirus small T antigen determines cell transformation through allosteric FBW7 WD40 domain targeting.

Authors:  Nnenna Nwogu; Luz E Ortiz; Hyun Jin Kwun
Journal:  Oncogenesis       Date:  2020-05-19       Impact factor: 7.485

Review 9.  Major Advances in Targeted Protein Degradation: PROTACs, LYTACs, and MADTACs.

Authors:  Shanique Alabi; Craig Crews
Journal:  J Biol Chem       Date:  2021-04-08       Impact factor: 5.157

Review 10.  Development of inhibitors in the ubiquitination cascade.

Authors:  Wei Zhang; Sachdev S Sidhu
Journal:  FEBS Lett       Date:  2013-11-12       Impact factor: 4.124
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.