Literature DB >> 20617245

Synthesis and bacterial biofilm inhibition studies of ethyl N-(2-phenethyl) carbamate derivatives.

Steven A Rogers1, Daniel C Whitehead, Trey Mullikin, Christian Melander.   

Abstract

An 88 member library based upon the marine bacterial metabolite ethyl N-(2-phenethyl) carbamate was evaluated for bacterial biofilm inhibition against a panel of medically relevant strains. These studies culminated in the discovery of a new class of molecules capable of inhibiting the formation of S. aureus biofilms with low micromolar IC(50) values.

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Year:  2010        PMID： 20617245     DOI： 10.1039/c0ob00063a

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  14 in total

Review 1.  Small molecule control of bacterial biofilms.

Authors:  Roberta J Worthington; Justin J Richards; Christian Melander
Journal:  Org Biomol Chem       Date:  2012-10-07       Impact factor: 3.876

2.  2-Aminopyrimidine as a novel scaffold for biofilm modulation.

Authors:  Erick A Lindsey; Roberta J Worthington; Cristina Alcaraz; Christian Melander
Journal:  Org Biomol Chem       Date:  2012-02-02       Impact factor: 3.876

3.  Natural products as inspiration for the development of bacterial antibiofilm agents.

Authors:  Roberta J Melander; Akash K Basak; Christian Melander
Journal:  Nat Prod Rep       Date:  2020-07-01       Impact factor: 13.423

4.  Flustramine inspired synthesis and biological evaluation of pyrroloindoline triazole amides as novel inhibitors of bacterial biofilms.

Authors:  Cynthia Bunders; John Cavanagh; Christian Melander
Journal:  Org Biomol Chem       Date:  2011-06-15       Impact factor: 3.876

5.  Inhibition and breaking of advanced glycation end-products (AGEs) with bis-2-aminoimidazole derivatives.

Authors:  Mike A Richardson; Robert E Furlani; Brendan K Podell; David F Ackart; Jessica D Haugen; Roberta J Melander; Christian Melander; Randall J Basaraba
Journal:  Tetrahedron Lett       Date:  2015       Impact factor: 2.415

6.  Potentiation of Francisella Resistance to Conventional Antibiotics through Small Molecule Adjuvants.

Authors:  Matthew D Stephens; Veroncia B Hubble; Robert K Ernst; Monique L van Hoek; Roberta J Melander; John Cavanagh; Christian Melander
Journal:  Medchemcomm       Date:  2015-09-30       Impact factor: 3.597

7.  Evaluation of ethyl N-(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus.

Authors:  Matthew D Stephens; Nisakorn Yodsanit; Christian Melander
Journal:  Org Biomol Chem       Date:  2016-07-12       Impact factor: 3.876

Review 8.  High-Throughput Approaches for the Identification of Pseudomonas aeruginosa Antivirulents.

Authors:  Donghoon Kang; Liyang Zhang; Natalia V Kirienko
Journal:  mBio       Date:  2021-05-04       Impact factor: 7.867

9.  Non-traditional antibacterial screening approaches for the identification of novel inhibitors of the glyoxylate shunt in gram-negative pathogens.

Authors:  Kelly C Fahnoe; Mark E Flanagan; Glenn Gibson; Veerabahu Shanmugasundaram; Ye Che; Andrew P Tomaras
Journal:  PLoS One       Date:  2012-12-11       Impact factor: 3.240

Review 10.  Inhibition of Virulence Factors and Biofilm Formation of Acinetobacter Baumannii by Naturally-derived and Synthetic Drugs.

Authors:  Nilushi Indika Bamunuarachchi; Fazlurrahman Khan; Young-Mog Kim
Journal:  Curr Drug Targets       Date:  2021       Impact factor: 2.937
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