Literature DB >> 20597533

Onionin A from Allium cepa inhibits macrophage activation.

Mona El-Aasr1, Yukio Fujiwara, Motohiro Takeya, Tsuyoshi Ikeda, Sachiko Tsukamoto, Masateru Ono, Daisuke Nakano, Masafumi Okawa, Junei Kinjo, Hitoshi Yoshimitsu, Toshihiro Nohara.   

Abstract

Onionin A (1), a new, stable, sulfur-containing compound, was isolated from acetone extracts of bulbs of onion (Allium cepa), and its structure was characterized as 3,4-dimethyl-5-(1E-propenyl)-tetrahydrothiophen-2-sulfoxide-S-oxide, on the basis of the results of spectroscopic analysis. This compound showed the potential to suppress tumor-cell proliferation by inhibiting the polarization of M2 alternatively activated macrophages.

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Year:  2010        PMID： 20597533     DOI： 10.1021/np100105u

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  12 in total

1.  New cyclic sulfides, garlicnins I2, M, N, and O, from Allium sativum.

Authors:  Toshihiro Nohara; Masateru Ono; Naho Nishioka; Fuka Masuda; Yukio Fujiwara; Tsuyoshi Ikeda; Daisuke Nakano; Junei Kinjo
Journal:  J Nat Med       Date:  2017-10-30       Impact factor: 2.343

Review 2.  Cancer prevention and therapy through the modulation of the tumor microenvironment.

Authors:  Stephanie C Casey; Amedeo Amedei; Katia Aquilano; Asfar S Azmi; Fabian Benencia; Dipita Bhakta; Alan E Bilsland; Chandra S Boosani; Sophie Chen; Maria Rosa Ciriolo; Sarah Crawford; Hiromasa Fujii; Alexandros G Georgakilas; Gunjan Guha; Dorota Halicka; William G Helferich; Petr Heneberg; Kanya Honoki; W Nicol Keith; Sid P Kerkar; Sulma I Mohammed; Elena Niccolai; Somaira Nowsheen; H P Vasantha Rupasinghe; Abbas Samadi; Neetu Singh; Wamidh H Talib; Vasundara Venkateswaran; Richard L Whelan; Xujuan Yang; Dean W Felsher
Journal:  Semin Cancer Biol       Date:  2015-04-10       Impact factor: 15.707

3.  New cyclic sulfides extracted from Allium sativum: garlicnins P, J2, and Q.

Authors:  Toshihiro Nohara; Masateru Ono; Naho Nishioka; Fuka Masuda; Yukio Fujiwara; Tsuyoshi Ikeda; Daisuke Nakano; Junei Kinjo
Journal:  J Nat Med       Date:  2017-11-20       Impact factor: 2.343

4.  Two new bicyclic sulfoxides from Welsh onion.

Authors:  Toshihiro Nohara; Yukio Fujiwara; Tsuyoshi Ikeda; Kotaro Murakami; Masateru Ono; Mona El-Aasr; Daisuke Nakano; Junei Kinjo
Journal:  J Nat Med       Date:  2015-12-16       Impact factor: 2.343

5.  The Effect of Allium cepa Extract on Lung Oxidant, Antioxidant, and Immunological Biomarkers in Ovalbumin-Sensitized Rats.

Authors:  N Marefati; N Eftekhar; M Kaveh; J Boskabadi; F Beheshti; M H Boskabady
Journal:  Med Princ Pract       Date:  2018-02-22       Impact factor: 1.927

Review 6.  Modulation of the tumor microenvironment by natural agents: implications for cancer prevention and therapy.

Authors:  Haseeb Zubair; Mohammad Aslam Khan; Shashi Anand; Sanjeev Kumar Srivastava; Seema Singh; Ajay Pratap Singh
Journal:  Semin Cancer Biol       Date:  2020-05-26       Impact factor: 15.707

7.  Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages.

Authors:  Junko Tsuboki; Yukio Fujiwara; Hasita Horlad; Daisuke Shiraishi; Toshihiro Nohara; Shingo Tayama; Takeshi Motohara; Yoichi Saito; Tsuyoshi Ikeda; Kiyomi Takaishi; Hironori Tashiro; Yukihiro Yonemoto; Hidetaka Katabuchi; Motohiro Takeya; Yoshihiro Komohara
Journal:  Sci Rep       Date:  2016-07-12       Impact factor: 4.379

Review 8.  Macrophages: Their role, activation and polarization in pulmonary diseases.

Authors:  Shweta Arora; Kapil Dev; Beamon Agarwal; Pragnya Das; Mansoor Ali Syed
Journal:  Immunobiology       Date:  2017-11-12       Impact factor: 3.144

Review 9.  A review of anti-inflammatory, antioxidant, and immunomodulatory effects of Allium cepa and its main constituents.

Authors:  Narges Marefati; Vahideh Ghorani; Farzaneh Shakeri; Marzie Boskabady; Farzaneh Kianian; Ramin Rezaee; Mohammad Hosein Boskabady
Journal:  Pharm Biol       Date:  2021-12       Impact factor: 3.503

Review 10.  Thiolane-type sulfides from garlic, onion, and Welsh onion.

Authors:  Toshihiro Nohara; Yukio Fujiwara; Mona El-Aasr; Tsuyoshi Ikeda; Masateru Ono; Daisuke Nakano; Junei Kinjo
Journal:  J Nat Med       Date:  2021-06-03       Impact factor: 2.343
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