| Literature DB >> 20595011 |
Abstract
Tissue fibrosis is most often referred to in its pathological context and is a major cause of progressive organ failure and death. Here, we consider fibrosis as an evolutionarily conserved, adaptive tissue response to injury. The role of NADPH oxidase 4 (Nox4) as a novel pro-fibrogenic mediator is highlighted. The concept that Nox4 may function as an antagonistically pleiotropic gene in age-associated fibrotic disorders is discussed. Copyright (c) 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20595011 PMCID： PMC2910205 DOI： 10.1016/j.biocel.2010.05.010
Source DB: PubMed Journal: Int J Biochem Cell Biol ISSN： 1357-2725 Impact factor: 5.085