PURPOSE: The aim of this pharmaco-epidemiological study was to evaluate the prevalence of oropharyngeal candidiasis (OPC) in cancer patients treated with chemotherapy and/or radiotherapy. METHODS AND MATERIALS: Signs and symptoms of OPC were noted for all patients. Antifungal therapeutic management was recorded in OPC patients. Patients receiving local antifungal treatments were monitored until the end of treatment. RESULTS: Enrolled in the study were 2,042 patients with solid tumor and/or lymphoma treated with chemotherapy and/or another systemic cancer treatment and/or radiotherapy. The overall prevalence of OPC was 9.6% (95% confidence interval, 8.4%-11.0%] in this population. It was most frequent in patients treated with combined chemoradiotherapy (22.0%) or with more than two cytotoxic agents (16.9%). Local antifungal treatments were prescribed in 75.0% of OPC patients as recommended by guidelines. The compliance to treatment was higher in patients receiving once-daily miconazole mucoadhesive buccal tablet (MBT; 88.2%) than in those treated with several daily mouthwashes of amphotericin B (40%) or nystatin (18.8%). CONCLUSION: OPC prevalence in treated cancer patients was high. Local treatments were usually prescribed as per guidelines. Compliance to local treatments was better with once-daily drugs.
PURPOSE: The aim of this pharmaco-epidemiological study was to evaluate the prevalence of oropharyngeal candidiasis (OPC) in cancerpatients treated with chemotherapy and/or radiotherapy. METHODS AND MATERIALS: Signs and symptoms of OPC were noted for all patients. Antifungal therapeutic management was recorded in OPC patients. Patients receiving local antifungal treatments were monitored until the end of treatment. RESULTS: Enrolled in the study were 2,042 patients with solid tumor and/or lymphoma treated with chemotherapy and/or another systemic cancer treatment and/or radiotherapy. The overall prevalence of OPC was 9.6% (95% confidence interval, 8.4%-11.0%] in this population. It was most frequent in patients treated with combined chemoradiotherapy (22.0%) or with more than two cytotoxic agents (16.9%). Local antifungal treatments were prescribed in 75.0% of OPC patients as recommended by guidelines. The compliance to treatment was higher in patients receiving once-daily miconazole mucoadhesive buccal tablet (MBT; 88.2%) than in those treated with several daily mouthwashes of amphotericin B (40%) or nystatin (18.8%). CONCLUSION: OPC prevalence in treated cancerpatients was high. Local treatments were usually prescribed as per guidelines. Compliance to local treatments was better with once-daily drugs.
Authors: Ana Mañas; Laura Cerezo; Alejandro de la Torre; Mariola García; Héctor Alburquerque; Blanca Ludeña; Ana Ruiz; Ana Pérez; Ana Escribano; Aurea Manso; Luis Alberto Glaria Journal: Clin Transl Oncol Date: 2012-09-08 Impact factor: 3.405
Authors: H Xu; T Sobue; A Thompson; Z Xie; K Poon; A Ricker; J Cervantes; P I Diaz; A Dongari-Bagtzoglou Journal: Cell Microbiol Date: 2013-10-17 Impact factor: 3.715
Authors: Lourimar Viana Nascimento F de Sousa; Vera Lúcia Santos; Andrea de Souza Monteiro; Marcus Vinicíus Dias-Souza; Sirlei Garcia Marques; Elaine Speziali de Faria; Elaine Alves de Oliveira Assunção; Simone Gonçalves Dos Santos; Juan Moises Zonis; Daniel Gomes de Alvarenga; Rodrigo Assunção de Holanda; Jaqueline Gontijo de Sousa; Kênia Valéria Dos Santos; Maria Aparecida de Resende Stoianoff Journal: BMC Infect Dis Date: 2016-02-23 Impact factor: 3.090