Literature DB >> 21171872

Miconazole mucoadhesive tablet for oropharyngeal candidiasis.

Rajesh V Lalla1, René-Jean Bensadoun.   

Abstract

Oropharyngeal candidiasis is a commonly encountered problem in daily clinical practice. Topical therapies for oropharyngeal candidiasis are considered preferable to systemic therapies in most patient populations. However, traditional topical therapies have limitations including short contact time with the oral mucosa and the need for multiple doses each day. Miconazole mucoadhesive tablet has recently been approved in Europe (Loramyc®) and the USA (Oravig™) for the treatment of oropharyngeal candidiasis. This tablet adheres to the oral mucosa and provides sustained local release of miconazole over a period of several hours with just one daily application. This article reviews the pharmacology, safety and efficacy of this novel agent.

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Year:  2011        PMID： 21171872      PMCID： PMC3076938          DOI： 10.1586/eri.10.152

Source DB:  PubMed          Journal:  Expert Rev Anti Infect Ther        ISSN： 1478-7210            Impact factor:   5.091


  8 in total

1.  Randomized, comparative, double-blind, double-dummy, multicenter trial of miconazole buccal tablet and clotrimazole troches for the treatment of oropharyngeal candidiasis: study of miconazole Lauriad® efficacy and safety (SMiLES).

Authors:  José A Vazquez; Lauren L Patton; Joel B Epstein; Padaruth Ramlachan; Ismail Mitha; Zoja Noveljic; Jan Fourie; Brian Conway; Rajesh V Lalla; Andrei Barasch; Pierre Attali
Journal:  HIV Clin Trials       Date:  2010 Jul-Aug

Review 2.  A systematic review of oral fungal infections in patients receiving cancer therapy.

Authors:  Rajesh V Lalla; Marie C Latortue; Catherine H Hong; Anura Ariyawardana; Sandra D'Amato-Palumbo; Dena J Fischer; Andrew Martof; Ourania Nicolatou-Galitis; Lauren L Patton; Linda S Elting; Fred K L Spijkervet; Michael T Brennan
Journal:  Support Care Cancer       Date:  2010-05-08       Impact factor: 3.603

3.  Incidence of oral candidiasis and oral hairy leukoplakia in HIV-infected adults in North Carolina.

Authors:  Amit Chattopadhyay; Daniel J Caplan; Gary D Slade; Diane C Shugars; Hsaio-Chuan Tien; Lauren L Patton
Journal:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod       Date:  2005-01

4.  Prevalence and treatment management of oropharyngeal candidiasis in cancer patients: results of the French CANDIDOSCOPE study.

Authors:  Joseph Gligorov; Laurent Bastit; Honorine Gervais; Mehdi Henni; Widad Kahila; Daniel Lepille; Elisabeth Luporsi; Giuseppe Sasso; Charles Varette; David Azria
Journal:  Int J Radiat Oncol Biol Phys       Date:  2010-06-18       Impact factor: 7.038

5.  Oral candidiasis and oral yeast carriage among institutionalised South African paediatric HIV/AIDS patients.

Authors:  Elaine Blignaut
Journal:  Mycopathologia       Date:  2007-02-12       Impact factor: 2.574

6.  Antifungal activity of miconazole against recent Candida strains.

Authors:  N Isham; M A Ghannoum
Journal:  Mycoses       Date:  2009-06-15       Impact factor: 4.377

7.  Comparison of the efficacy and safety of miconazole 50-mg mucoadhesive buccal tablets with miconazole 500-mg gel in the treatment of oropharyngeal candidiasis: a prospective, randomized, single-blind, multicenter, comparative, phase III trial in patients treated with radiotherapy for head and neck cancer.

Authors:  Rene-Jean Bensadoun; Jamel Daoud; Brahim El Gueddari; Laurent Bastit; Rene Gourmet; Andrzej Rosikon; Christophe Allavena; Philippe Céruse; Gilles Calais; Pierre Attali
Journal:  Cancer       Date:  2008-01-01       Impact factor: 6.860

8.  Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America.

Authors:  Peter G Pappas; Carol A Kauffman; David Andes; Daniel K Benjamin; Thierry F Calandra; John E Edwards; Scott G Filler; John F Fisher; Bart-Jan Kullberg; Luis Ostrosky-Zeichner; Annette C Reboli; John H Rex; Thomas J Walsh; Jack D Sobel
Journal:  Clin Infect Dis       Date:  2009-03-01       Impact factor: 9.079
  8 in total
  3 in total

1.  Prophylactic efficacy of enteral miconazole administration for neonatal intestinal perforation and its potential mechanism.

Authors:  Motofumi Torikai; Satoshi Ibara; Satoshi Ieiri; Takashi Hamada; Hiroyuki Noguchi; Kazunobu Sueyoshi; Takeo Fukuda; Kazuhiro Abeyama
Journal:  Pediatr Surg Int       Date:  2016-07-29       Impact factor: 1.827

2.  Preparation, characterization, and evaluation of amphotericin B-loaded MPEG-PCL-g-PEI micelles for local treatment of oral Candida albicans.

Authors:  Li Zhou; Peipei Zhang; Zhuo Chen; Shaona Cai; Ting Jing; Huihui Fan; Fei Mo; Jiye Zhang; Rong Lin
Journal:  Int J Nanomedicine       Date:  2017-06-06

Review 3.  Molecular Mapping of Antifungal Mechanisms Accessing Biomaterials and New Agents to Target Oral Candidiasis.

Authors:  Valentina Anuța; Marina-Theodora Talianu; Cristina-Elena Dinu-Pîrvu; Mihaela Violeta Ghica; Răzvan Mihai Prisada; Mădălina Georgiana Albu Kaya; Lăcrămioara Popa
Journal:  Int J Mol Sci       Date:  2022-07-07       Impact factor: 6.208
  3 in total

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