Literature DB >> 20590401

Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease.

Matthew J Chiocco1, Xuguang Zhu, Donna Walther, Olga Pletnikova, Juan C Troncoso, George R Uhl, Qing-Rong Liu.   

Abstract

Fine mapping of calcineurin (PPP3CA) gene identified single nucleotide polymorphisms (SNPs) and simple sequence repeat polymorphisms that are associated with addiction vulnerability. A trinucleotide repeat marker, located in the 5'untranslated region (5'UTR) of the PPP3CA mRNA, exhibited significantly different genotype and allele frequencies between abusers and controls in the NIDA African-American sample. The polymorphism showed allelic-specific expression in mRNA extracted from postmortem brain specimens. Novel alternatively spliced isoforms of PPP3CA were identified and their expressions were found altered in brain regions of postmortem Alzheimer's disease patients. These data underscore the importance of calcineurin gene in the molecular mechanism of addiction and Alzheimer's diseases.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20590401      PMCID： PMC3031160          DOI： 10.3109/10826084.2010.482449

Source DB:  PubMed          Journal:  Subst Use Misuse        ISSN： 1082-6084            Impact factor:   2.164


  25 in total

1.  GOLD--graphical overview of linkage disequilibrium.

Authors:  G R Abecasis; W O Cookson
Journal:  Bioinformatics       Date:  2000-02       Impact factor: 6.937

2.  A novel calcineurin splice variant that modifies calcineurin activity.

Authors:  A Reuter; J Mi; I Sehrsam; A C Ludolph; H Völkel
Journal:  Eur J Biochem       Date:  2001-11

3.  A comparison of bayesian methods for haplotype reconstruction from population genotype data.

Authors:  Matthew Stephens; Peter Donnelly
Journal:  Am J Hum Genet       Date:  2003-10-20       Impact factor: 11.025

4.  Decreased activity and increased aggregation of brain calcineurin during aging.

Authors:  Abdulbaki Agbas; Asma Zaidi; Elias K Michaelis
Journal:  Brain Res       Date:  2005-09-08       Impact factor: 3.252

5.  Differential effects of calcineurin inhibition and protein kinase A activation on nucleus accumbens amphetamine-produced conditioned place preference in rats.

Authors:  Todor V Gerdjikov; Richard J Beninger
Journal:  Eur J Neurosci       Date:  2005-08       Impact factor: 3.386

6.  Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory.

Authors:  I M Mansuy; M Mayford; B Jacob; E R Kandel; M E Bach
Journal:  Cell       Date:  1998-01-09       Impact factor: 41.582

7.  Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods.

Authors:  R L Kincaid; P R Giri; S Higuchi; J Tamura; S C Dixon; C A Marietta; D A Amorese; B M Martin
Journal:  J Biol Chem       Date:  1990-07-05       Impact factor: 5.157

8.  Polysubstance abuse-vulnerability genes: genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms.

Authors:  G R Uhl; Q R Liu; D Walther; J Hess; D Naiman
Journal:  Am J Hum Genet       Date:  2001-11-06       Impact factor: 11.025

9.  Calcineurin (phosphatase 2B) is present in neurons containing neurofibrillary tangles and in a subset of senile plaques in Alzheimer's disease.

Authors:  J P Brion; A M Couck; J L Conreur
Journal:  Neurodegeneration       Date:  1995-03

10.  Dysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic target.

Authors:  Cheng-Xin Gong; Fei Liu; Inge Grundke-Iqbal; Khalid Iqbal
Journal:  J Biomed Biotechnol       Date:  2006
View more
  10 in total

Review 1.  Protein phosphatases and Alzheimer's disease.

Authors:  Steven P Braithwaite; Jeffry B Stock; Paul J Lombroso; Angus C Nairn
Journal:  Prog Mol Biol Transl Sci       Date:  2012       Impact factor: 3.622

Review 2.  Alternative splicing isoforms in health and disease.

Authors:  Hyoung Kyu Kim; Michael Huy Cuong Pham; Kyung Soo Ko; Byoung Doo Rhee; Jin Han
Journal:  Pflugers Arch       Date:  2018-03-13       Impact factor: 3.657

3.  DISC1 as a Possible Genetic Contribution to Opioid Dependence in a Polish Sample.

Authors:  Sylwia Fudalej; Andrzej Jakubczyk; Maciej Kopera; Jerzy Piwonski; Wojciech Bielecki; Wojciech Drygas; Krystyna Wasilewska; Mark Ilgen; Amy Bohnert; Kristen Barry; Rafał Płoski; Frederic C Blow; Marcin Wojnar
Journal:  J Stud Alcohol Drugs       Date:  2016-03       Impact factor: 2.582

4.  Novel calcineurin A (PPP3CA) variant associated with epilepsy, constitutive enzyme activation and downregulation of protein expression.

Authors:  Małgorzata Rydzanicz; Małgorzata Wachowska; Erik C Cook; Paweł Lisowski; Bożena Kuźniewska; Krystyna Szymańska; Sebastian Diecke; Alessandro Prigione; Krzysztof Szczałuba; Aleksandra Szybińska; Agnieszka Koppolu; Victor Murcia Pienkowski; Joanna Kosińska; Małgorzata Wiweger; Grażyna Kostrzewa; Małgorzata Brzozowska; Dorota Domańska-Pakieła; Elżbieta Jurkiewicz; Piotr Stawiński; Agnieszka Gromadka; Piotr Zielenkiewicz; Urszula Demkow; Magdalena Dziembowska; Jacek Kuźnicki; Trevor P Creamer; Rafał Płoski
Journal:  Eur J Hum Genet       Date:  2018-09-25       Impact factor: 4.246

5.  Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways.

Authors:  Joel Gelernter; Henry R Kranzler; Richard Sherva; Ryan Koesterer; Laura Almasy; Hongyu Zhao; Lindsay A Farrer
Journal:  Biol Psychiatry       Date:  2013-10-19       Impact factor: 13.382

6.  Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy.

Authors:  Jeong-Sun Seo; Seungbok Lee; Jong-Yeon Shin; Yu Jin Hwang; Hyesun Cho; Seong-Keun Yoo; Yunha Kim; Sungsu Lim; Yun Kyung Kim; Eun Mi Hwang; Su Hyun Kim; Chong-Hyun Kim; Seung Jae Hyeon; Ji-Young Yun; Jihye Kim; Yona Kim; Victor E Alvarez; Thor D Stein; Junghee Lee; Dong Jin Kim; Jong-Il Kim; Neil W Kowall; Hoon Ryu; Ann C McKee
Journal:  Exp Mol Med       Date:  2017-05-19       Impact factor: 8.718

7.  Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer's disease.

Authors:  Akitoyo Hishimoto; Olga Pletnikova; Doyle Lu Lang; Juan C Troncoso; Josephine M Egan; Qing-Rong Liu
Journal:  Alzheimers Res Ther       Date:  2019-03-21       Impact factor: 6.982

8.  DNA methylation profiling in the thalamus and hippocampus of postnatal malnourished mice, including effects related to long-term potentiation.

Authors:  Xiaoling Weng; Daizhan Zhou; Fatao Liu; Hong Zhang; Junyi Ye; Zhou Zhang; Di Zhang; Yinan Wang; Liming Tao; Lan Cao; Mengyuan Kan; Ting Wang; Guoyin Feng; Xiaolan Qin; Jihui Sun; Lin He; Yun Liu
Journal:  BMC Neurosci       Date:  2014-02-20       Impact factor: 3.288

9.  Association of the PPP3CA c.249G>A variant with clinical outcomes of tacrolimus-based therapy in kidney transplant recipients.

Authors:  Patricia C Salgado; Fabiana Dv Genvigir; Claudia R Felipe; Helio Tedesco-Silva; Jose O Medina-Pestana; Sonia Q Doi; Mario H Hirata; Rosario Dc Hirata
Journal:  Pharmgenomics Pers Med       Date:  2017-03-31

Review 10.  Anti-Inflammatory and Pro-Autophagy Effects of the Cannabinoid Receptor CB2R: Possibility of Modulation in Type 1 Diabetes.

Authors:  Qing-Rong Liu; Kanikkai Raja Aseer; Qin Yao; Xiaoming Zhong; Paritosh Ghosh; Jennifer F O'Connell; Josephine M Egan
Journal:  Front Pharmacol       Date:  2022-01-18       Impact factor: 5.810
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.