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Literature DB >> 11704927

Polysubstance abuse-vulnerability genes: genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms.

G R Uhl¹, Q R Liu, D Walther, J Hess, D Naiman.

Abstract

Strong genetic contributions to drug abuse vulnerability are well documented, but few chromosomal locations for human drug-abuse vulnerability alleles have been confirmed. We now identify chromosomal markers whose alleles distinguish drug abusers from control individuals in each of two samples, on the basis of pooled-sample microarray and association analyses. Reproducibly positive chromosomal regions defined by these markers in conjunction with previous results were especially unlikely to have been identified by chance. Positive markers identify the alcohol dehydrogenase (ADH) locus, flank the brain-derived neurotropic factor (BDNF) locus, and mark seven other regions previously linked to vulnerability to nicotine or alcohol abuse. These data support polygenic contributions of common allelic variants to polysubstance abuse vulnerability.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2001 PMID： 11704927 PMCID： PMC1235541 DOI： 10.1086/324467

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

45 in total

1. Comparison of tests for association and linkage in incomplete families.

Authors: A C Cervino; A V Hill
Journal: Am J Hum Genet Date: 2000-06-06 Impact factor: 11.025

2. Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism.

Authors: M Osier; A J Pakstis; J R Kidd; J F Lee; S J Yin; H C Ko; H J Edenberg; R B Lu; K K Kidd
Journal: Am J Hum Genet Date: 1999-04 Impact factor: 11.025

3. Susceptibility genes for nicotine dependence: a genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study.

Authors: R E Straub; P F Sullivan; Y Ma; M V Myakishev; C Harris-Kerr; B Wormley; B Kadambi; H Sadek; M A Silverman; B T Webb; M C Neale; C M Bulik; P R Joyce; K S Kendler
Journal: Mol Psychiatry Date: 1999-03 Impact factor: 15.992

Review 4. Molecular genetics of substance abuse vulnerability: a current approach.

Authors: G R Uhl
Journal: Neuropsychopharmacology Date: 1999-01 Impact factor: 7.853

5. Genome-wide search for genes affecting the risk for alcohol dependence.

Authors: T Reich; H J Edenberg; A Goate; J T Williams; J P Rice; P Van Eerdewegh; T Foroud; V Hesselbrock; M A Schuckit; K Bucholz; B Porjesz; T K Li; P M Conneally; J I Nurnberger; J A Tischfield; R R Crowe; C R Cloninger; W Wu; S Shears; K Carr; C Crose; C Willig; H Begleiter
Journal: Am J Med Genet Date: 1998-05-08

6. Enhancement of locomotor activity and conditioned reward to cocaine by brain-derived neurotrophic factor.

Authors: B A Horger; C A Iyasere; M T Berhow; C J Messer; E J Nestler; J R Taylor
Journal: J Neurosci Date: 1999-05-15 Impact factor: 6.167

7. Cocaine use, abuse and dependence in a population-based sample of female twins.

Authors: K S Kendler; C A Prescott
Journal: Br J Psychiatry Date: 1998-10 Impact factor: 9.319

8. Preferential effects of nicotine and 4-(N-methyl-N-nitrosamine)-1-(3-pyridyl)-1-butanone on mitochondrial glutathione S-transferase A4-4 induction and increased oxidative stress in the rat brain.

Authors: S V Bhagwat; C Vijayasarathy; H Raza; J Mullick; N G Avadhani
Journal: Biochem Pharmacol Date: 1998-10-01 Impact factor: 5.858

9. Familial transmission of substance use disorders.

Authors: K R Merikangas; M Stolar; D E Stevens; J Goulet; M A Preisig; B Fenton; H Zhang; S S O'Malley; B J Rounsaville
Journal: Arch Gen Psychiatry Date: 1998-11

10. Co-occurrence of abuse of different drugs in men: the role of drug-specific and shared vulnerabilities.

Authors: M T Tsuang; M J Lyons; J M Meyer; T Doyle; S A Eisen; J Goldberg; W True; N Lin; R Toomey; L Eaves
Journal: Arch Gen Psychiatry Date: 1998-11

89 in total

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Journal: Curr Allergy Asthma Rep Date: 2002-07 Impact factor: 4.806

2. Mining microarrays for metabolic meaning: nutritional regulation of hypothalamic gene expression.

Authors: Charles V Mobbs; Kelvin Yen; Jason Mastaitis; Ha Nguyen; Elizabeth Watson; Elisa Wurmbach; Stuart C Sealfon; Andrew Brooks; Stephen R J Salton
Journal: Neurochem Res Date: 2004-06 Impact factor: 3.996

3. Alternative transcription of sodium/bicarbonate transporter SLC4A7 gene enhanced by single nucleotide polymorphisms.

Authors: Hae Jeong Park; Soojung Lee; Eunji Ju; Jayre A Jones; Inyeong Choi
Journal: Physiol Genomics Date: 2017-01-13 Impact factor: 3.107

4. The role of amygdaloid brain-derived neurotrophic factor, activity-regulated cytoskeleton-associated protein and dendritic spines in anxiety and alcoholism.

Authors: Sachin Moonat; Amul J Sakharkar; Huaibo Zhang; Subhash C Pandey
Journal: Addict Biol Date: 2010-12-23 Impact factor: 4.280

5. Pooled association genome scanning: validation and use to identify addiction vulnerability loci in two samples.

Authors: Qing-Rong Liu; Tomas Drgon; Donna Walther; Catherine Johnson; Oxanna Poleskaya; Judith Hess; George R Uhl
Journal: Proc Natl Acad Sci U S A Date: 2005-08-09 Impact factor: 11.205

Review 6. Molecular genetics of addiction vulnerability.

Authors: George R Uhl
Journal: NeuroRx Date: 2006-07

Review 7. "Higher order" addiction molecular genetics: convergent data from genome-wide association in humans and mice.

Authors: George R Uhl; Tomas Drgon; Catherine Johnson; Oluwatosin O Fatusin; Qing-Rong Liu; Carlo Contoreggi; Chuan-Yun Li; Kari Buck; John Crabbe
Journal: Biochem Pharmacol Date: 2007-07-25 Impact factor: 5.858

8. Association between Val66Met brain-derived neurotrophic factor (BDNF) gene polymorphism and post-treatment relapse in alcohol dependence.

Authors: Marcin Wojnar; Kirk J Brower; Stephen Strobbe; Mark Ilgen; Halina Matsumoto; Izabela Nowosad; Elzbieta Sliwerska; Margit Burmeister
Journal: Alcohol Clin Exp Res Date: 2009-01-27 Impact factor: 3.455

9. Gut microbiota modulates alcohol withdrawal-induced anxiety in mice.

Authors: Hui-Wen Xiao; Chang Ge; Guo-Xing Feng; Yuan Li; Dan Luo; Jia-Li Dong; Hang Li; Haichao Wang; Ming Cui; Sai-Jun Fan
Journal: Toxicol Lett Date: 2018-01-31 Impact factor: 4.372

Review 10. Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

Authors: George R Uhl; Tomas Drgon; Catherine Johnson; Chuan-Yun Li; Carlo Contoreggi; Judith Hess; Daniel Naiman; Qing-Rong Liu
Journal: Ann N Y Acad Sci Date: 2008-10 Impact factor: 5.691