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Literature DB >> 20581457

Long antisense non-coding RNAs and their role in transcription and oncogenesis.

Abstract

Long non-coding RNAs are estimated to qualitatively represent ~98% of expressed transcripts in human cells, a large proportion of which is antisense to protein-coding and non-coding transcripts. Here we review evidence from several experimental systems that suggests long antisense non-coding RNAs are involved in the transcriptional regulation of gene expression by altering epigenetic states at both adjacent and distal loci. We also review the initial evidence for a role of endogenous long antisense non-coding RNAs in oncogenic cellular transformation.

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Year: 2010 PMID： 20581457 PMCID： PMC3040850 DOI： 10.4161/cc.9.13.12145

Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534

50 in total

1. Antisense RNA stabilization induces transcriptional gene silencing via histone deacetylation in S. cerevisiae.

Authors: Jurgi Camblong; Nahid Iglesias; Céline Fickentscher; Guennaelle Dieppois; Françoise Stutz
Journal: Cell Date: 2007-11-16 Impact factor: 41.582

2. Promoter-associated RNA is required for RNA-directed transcriptional gene silencing in human cells.

Authors: Jiang Han; Daniel Kim; Kevin V Morris
Journal: Proc Natl Acad Sci U S A Date: 2007-07-17 Impact factor: 11.205

3. PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element.

Authors: Alexander K Ebralidze; Florence C Guibal; Ulrich Steidl; Pu Zhang; Sanghoon Lee; Boris Bartholdy; Meritxell Alberich Jorda; Victoria Petkova; Frank Rosenbauer; Gang Huang; Tajhal Dayaram; Johanna Klupp; Karen B O'Brien; Britta Will; Maarten Hoogenkamp; Katherine L B Borden; Constanze Bonifer; Daniel G Tenen
Journal: Genes Dev Date: 2008-08-01 Impact factor: 11.361

4. Transcriptome complexity in a genome-reduced bacterium.

Authors: Marc Güell; Vera van Noort; Eva Yus; Wei-Hua Chen; Justine Leigh-Bell; Konstantinos Michalodimitrakis; Takuji Yamada; Manimozhiyan Arumugam; Tobias Doerks; Sebastian Kühner; Michaela Rode; Mikita Suyama; Sabine Schmidt; Anne-Claude Gavin; Peer Bork; Luis Serrano
Journal: Science Date: 2009-11-27 Impact factor: 47.728

Review 5. Regulation of gene expression by natural antisense RNA transcripts.

Authors: R Knee; P R Murphy
Journal: Neurochem Int Date: 1997-09 Impact factor: 3.921

6. An epigenetic mechanism for carcinogenesis.

Authors: R Tsanev; B Sendov
Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol Date: 1971

7. A noncoding antisense RNA in tie-1 locus regulates tie-1 function in vivo.

Authors: Keguo Li; Yannick Blum; Anjali Verma; Zhong Liu; Kallal Pramanik; Noah R Leigh; Chang Z Chun; Ganesh V Samant; Baofeng Zhao; Maija K Garnaas; Mark A Horswill; Stephen A Stanhope; Paula E North; Robert Q Miao; George A Wilkinson; Markus Affolter; Ramani Ramchandran
Journal: Blood Date: 2009-10-30 Impact factor: 22.113

8. Characterization of an endogenous RNA transcript with homology to the antisense strand of the human c-myc gene.

Authors: P Celano; C M Berchtold; D L Kizer; A Weeraratna; B D Nelkin; S B Baylin; R A Casero
Journal: J Biol Chem Date: 1992-07-25 Impact factor: 5.157

Review 9. Long antisense non-coding RNAs function to direct epigenetic complexes that regulate transcription in human cells.

Authors: Kevin V Morris
Journal: Epigenetics Date: 2009-07-17 Impact factor: 4.528

10. Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage.

Authors: Salah Mahmoudi; Sofia Henriksson; Martin Corcoran; Cristina Méndez-Vidal; Klas G Wiman; Marianne Farnebo
Journal: Mol Cell Date: 2009-02-27 Impact factor: 17.970

35 in total

Review 1. Long non-coding RNAs and cancer: a new frontier of translational research?

Authors: R Spizzo; M I Almeida; A Colombatti; G A Calin
Journal: Oncogene Date: 2012-01-23 Impact factor: 9.867

2. Dysregulation of autoantigen genes in ANCA-associated vasculitis involves alternative transcripts and new protein synthesis.

Authors: Elizabeth A McInnis; Anshul K Badhwar; Akhil Muthigi; Olivier M Lardinois; S Colby Allred; Jiajin Yang; Meghan E Free; J Charles Jennette; Gloria A Preston; Ronald J Falk; Dominic J Ciavatta
Journal: J Am Soc Nephrol Date: 2014-07-24 Impact factor: 10.121

10. RNA-seq Analysis of δ9-Tetrahydrocannabinol-treated T Cells Reveals Altered Gene Expression Profiles That Regulate Immune Response and Cell Proliferation.

Authors: Xiaoming Yang; Marpe Bam; Prakash S Nagarkatti; Mitzi Nagarkatti
Journal: J Biol Chem Date: 2016-06-06 Impact factor: 5.157

Long antisense non-coding RNAs and their role in transcription and oncogenesis.

1. Antisense RNA stabilization induces transcriptional gene silencing via histone deacetylation in S. cerevisiae.

2. Promoter-associated RNA is required for RNA-directed transcriptional gene silencing in human cells.

3. PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element.

4. Transcriptome complexity in a genome-reduced bacterium.

Review 5. Regulation of gene expression by natural antisense RNA transcripts.

6. An epigenetic mechanism for carcinogenesis.

7. A noncoding antisense RNA in tie-1 locus regulates tie-1 function in vivo.

8. Characterization of an endogenous RNA transcript with homology to the antisense strand of the human c-myc gene.

Review 9. Long antisense non-coding RNAs function to direct epigenetic complexes that regulate transcription in human cells.

10. Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage.

Review 1. Long non-coding RNAs and cancer: a new frontier of translational research?

2. Dysregulation of autoantigen genes in ANCA-associated vasculitis involves alternative transcripts and new protein synthesis.

Review 3. Noncoding RNA and colorectal cancer: its epigenetic role.

Review 4. Long non-coding RNA targeting and transcriptional de-repression.

Review 5. Library construction for next-generation sequencing: overviews and challenges.

Review 6. Retroviral oncogenes: a historical primer.

7. Transcription-induced DNA toxicity at trinucleotide repeats: double bubble is trouble.

Review 8. Non-coding RNA and antisense RNA. Nature's trash or treasure?

9. Mismatch repair enhances convergent transcription-induced cell death at trinucleotide repeats by activating ATR.

10. RNA-seq Analysis of δ9-Tetrahydrocannabinol-treated T Cells Reveals Altered Gene Expression Profiles That Regulate Immune Response and Cell Proliferation.