Literature DB >> 18676813

PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element.

Alexander K Ebralidze1, Florence C Guibal, Ulrich Steidl, Pu Zhang, Sanghoon Lee, Boris Bartholdy, Meritxell Alberich Jorda, Victoria Petkova, Frank Rosenbauer, Gang Huang, Tajhal Dayaram, Johanna Klupp, Karen B O'Brien, Britta Will, Maarten Hoogenkamp, Katherine L B Borden, Constanze Bonifer, Daniel G Tenen.   

Abstract

The transcription factor PU.1 is an important regulator of hematopoiesis; precise expression levels are critical for normal hematopoietic development and suppression of leukemia. We show here that noncoding antisense RNAs are important modulators of proper dosages of PU.1. Antisense and sense RNAs are regulated by shared evolutionarily conserved cis-regulatory elements, and we can show that antisense RNAs inhibit PU.1 expression by modulating mRNA translation. We propose that such antisense RNAs will likely be important in the regulation of many genes and may be the reason for the large number of overlapping complementary transcripts with so far unknown function.

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Year:  2008        PMID： 18676813      PMCID： PMC2492744          DOI： 10.1101/gad.1654808

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  35 in total

1.  DNA methylation and chromatin structure regulate PU.1 expression.

Authors:  L Amaravadi; M J Klemsz
Journal:  DNA Cell Biol       Date:  1999-12       Impact factor: 3.311

2.  Looping and interaction between hypersensitive sites in the active beta-globin locus.

Authors:  Bas Tolhuis; Robert Jan Palstra; Erik Splinter; Frank Grosveld; Wouter de Laat
Journal:  Mol Cell       Date:  2002-12       Impact factor: 17.970

3.  Elongator interactions with nascent mRNA revealed by RNA immunoprecipitation.

Authors:  Christopher Gilbert; Arnold Kristjuhan; G Sebastiaan Winkler; Jesper Q Svejstrup
Journal:  Mol Cell       Date:  2004-05-21       Impact factor: 17.970

4.  Regulation of B lymphocyte and macrophage development by graded expression of PU.1.

Authors:  R P DeKoter; H Singh
Journal:  Science       Date:  2000-05-26       Impact factor: 47.728

5.  PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.

Authors:  Gang Huang; Pu Zhang; Hideyo Hirai; Shannon Elf; Xiaomei Yan; Zhao Chen; Steffen Koschmieder; Yutaka Okuno; Tajhal Dayaram; Joseph D Growney; Ramesh A Shivdasani; D Gary Gilliland; Nancy A Speck; Stephen D Nimer; Daniel G Tenen
Journal:  Nat Genet       Date:  2007-11-11       Impact factor: 38.330

6.  PU.1 (Spi-1) autoregulates its expression in myeloid cells.

Authors:  H Chen; D Ray-Gallet; P Zhang; C J Hetherington; D A Gonzalez; D E Zhang; F Moreau-Gachelin; D G Tenen
Journal:  Oncogene       Date:  1995-10-19       Impact factor: 9.867

7.  RNase Activities Are Reduced Concomitantly with Conservation of Total Cellular RNA and Ribosomes in O2-Deprived Seedling Roots of Maize.

Authors:  S. L. Fennoy; S. Jayachandran; J. Bailey-Serres
Journal:  Plant Physiol       Date:  1997-11       Impact factor: 8.340

8.  Small interfering RNA-induced transcriptional gene silencing in human cells.

Authors:  Kevin V Morris; Simon W-L Chan; Steven E Jacobsen; David J Looney
Journal:  Science       Date:  2004-08-05       Impact factor: 47.728

9.  PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain.

Authors:  Wendy D Cook; Benjamin J McCaw; Christopher Herring; Deborah L John; Simon J Foote; Stephen L Nutt; Jerry M Adams
Journal:  Blood       Date:  2004-08-10       Impact factor: 22.113

10.  A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia.

Authors:  Ulrich Steidl; Christian Steidl; Alexander Ebralidze; Björn Chapuy; Hye-Jung Han; Britta Will; Frank Rosenbauer; Annegret Becker; Katharina Wagner; Steffen Koschmieder; Susumu Kobayashi; Daniel B Costa; Thomas Schulz; Karen B O'Brien; Roel G W Verhaak; Ruud Delwel; Detlef Haase; Lorenz Trümper; Jürgen Krauter; Terumi Kohwi-Shigematsu; Frank Griesinger; Daniel G Tenen
Journal:  J Clin Invest       Date:  2007-09       Impact factor: 14.808
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  90 in total

1.  The lytic transcriptome of Kaposi's sarcoma-associated herpesvirus reveals extensive transcription of noncoding regions, including regions antisense to important genes.

Authors:  Sanjay Chandriani; Yiyang Xu; Don Ganem
Journal:  J Virol       Date:  2010-06-09       Impact factor: 5.103

2.  CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells.

Authors:  Karen B O'Brien; Meritxell Alberich-Jordà; Neelu Yadav; Olivier Kocher; Annalisa Diruscio; Alexander Ebralidze; Elena Levantini; Natasha J L Sng; Manoj Bhasin; Tyler Caron; Daehoon Kim; Ulrich Steidl; Gang Huang; Balázs Halmos; Scott J Rodig; Mark T Bedford; Daniel G Tenen; Susumu Kobayashi
Journal:  Development       Date:  2010-07       Impact factor: 6.868

Review 3.  Long antisense non-coding RNAs and their role in transcription and oncogenesis.

Authors:  Kevin V Morris; Peter K Vogt
Journal:  Cell Cycle       Date:  2010-07-01       Impact factor: 4.534

Review 4.  Making sense of antisense: seemingly noncoding RNAs antisense to the master regulator of Kaposi's sarcoma-associated herpesvirus lytic replication do not regulate that transcript but serve as mRNAs encoding small peptides.

Authors:  Yiyang Xu; Don Ganem
Journal:  J Virol       Date:  2010-03-31       Impact factor: 5.103

Review 5.  TDP43 and RNA instability in amyotrophic lateral sclerosis.

Authors:  Kaitlin Weskamp; Sami J Barmada
Journal:  Brain Res       Date:  2018-01-31       Impact factor: 3.252

6.  Integrative proteomic and transcriptomic analyses reveal multiple post-transcriptional regulatory mechanisms of mouse spermatogenesis.

Authors:  Haiyun Gan; Tanxi Cai; Xiwen Lin; Yujian Wu; Xiuxia Wang; Fuquan Yang; Chunsheng Han
Journal:  Mol Cell Proteomics       Date:  2013-01-16       Impact factor: 5.911

7.  Chromatin-remodeling factors mediate the balance of sense-antisense transcription at the FGF2 locus.

Authors:  Lori A McEachern; Paul R Murphy
Journal:  Mol Endocrinol       Date:  2014-02-19

8.  A rice cis-natural antisense RNA acts as a translational enhancer for its cognate mRNA and contributes to phosphate homeostasis and plant fitness.

Authors:  Mehdi Jabnoune; David Secco; Cécile Lecampion; Christophe Robaglia; Qingyao Shu; Yves Poirier
Journal:  Plant Cell       Date:  2013-10-04       Impact factor: 11.277

9.  Protein-coding cis-natural antisense transcripts have high and broad expression in Arabidopsis.

Authors:  Shuhua Zhan; Lewis Lukens
Journal:  Plant Physiol       Date:  2013-03-01       Impact factor: 8.340

10.  Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat.

Authors:  Claudia Carrieri; Laura Cimatti; Marta Biagioli; Anne Beugnet; Silvia Zucchelli; Stefania Fedele; Elisa Pesce; Isidre Ferrer; Licio Collavin; Claudio Santoro; Alistair R R Forrest; Piero Carninci; Stefano Biffo; Elia Stupka; Stefano Gustincich
Journal:  Nature       Date:  2012-10-14       Impact factor: 49.962
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