OBJECTIVE: We investigated the effect of low-tube-voltage CT angiography with a reduced volume of contrast agent on qualitative and quantitative parameters and the radiation dose in patients with peripheral arterial disease. METHODS:Eighty consecutive patients were divided into two groups; the protocol was 120 kVp and 1.8 ml/kg contrast agent (300 mgI/ml) in one group and 80 kVp and 1.2 ml/kg in the other. For quantitative analysis we calculated the mean arterial attenuation, the mean difference between maximum and minimum attenuation values, contrast-to-noise ratio (CNR), and figure of merit (FOM). For qualitative evaluation, we used visual scores. RESULTS: There were no significant intergroup differences in mean arterial attenuation (120 vs. 80 kVp: 331.6 ± 61.6 vs. 354.9 ± 61.9 HU) and in the mean difference between maximum and minimum attenuation (120 vs. 80 kVp: 52.2 ± 25.5 vs. 61.5 ± 27.5 HU). While the mean CNR was significantly higher at 120 than 80 kVp (38.4 ± 18.8 vs. 31.1 ± 15.3), the mean FOM was not significantly different (120 vs. 80 kVp: 1.3 ± 1.5 vs. 1.2 ± 1.2), and there was no significant intergroup difference in visual scores. The mean dose-length product was significantly lower at 80 than 120 kVp (1,024.3 ± 151.3 vs. 1,464.7 ± 208.7 mGy·cm). CONCLUSION: The 80-kVp protocol allows for reduction of the radiation dose by approximately 30% and the volume of contrast agent by more than 30% without deterioration of vascular enhancement and image quality.
RCT Entities:
OBJECTIVE: We investigated the effect of low-tube-voltage CT angiography with a reduced volume of contrast agent on qualitative and quantitative parameters and the radiation dose in patients with peripheral arterial disease. METHODS: Eighty consecutive patients were divided into two groups; the protocol was 120 kVp and 1.8 ml/kg contrast agent (300 mgI/ml) in one group and 80 kVp and 1.2 ml/kg in the other. For quantitative analysis we calculated the mean arterial attenuation, the mean difference between maximum and minimum attenuation values, contrast-to-noise ratio (CNR), and figure of merit (FOM). For qualitative evaluation, we used visual scores. RESULTS: There were no significant intergroup differences in mean arterial attenuation (120 vs. 80 kVp: 331.6 ± 61.6 vs. 354.9 ± 61.9 HU) and in the mean difference between maximum and minimum attenuation (120 vs. 80 kVp: 52.2 ± 25.5 vs. 61.5 ± 27.5 HU). While the mean CNR was significantly higher at 120 than 80 kVp (38.4 ± 18.8 vs. 31.1 ± 15.3), the mean FOM was not significantly different (120 vs. 80 kVp: 1.3 ± 1.5 vs. 1.2 ± 1.2), and there was no significant intergroup difference in visual scores. The mean dose-length product was significantly lower at 80 than 120 kVp (1,024.3 ± 151.3 vs. 1,464.7 ± 208.7 mGy·cm). CONCLUSION: The 80-kVp protocol allows for reduction of the radiation dose by approximately 30% and the volume of contrast agent by more than 30% without deterioration of vascular enhancement and image quality.
Authors: Rody Ouwendijk; Marianne de Vries; Peter M T Pattynama; Marc R H M van Sambeek; Michiel W de Haan; Theo Stijnen; Jos M A van Engelshoven; M G Myriam Hunink Journal: Radiology Date: 2005-07-14 Impact factor: 11.105
Authors: Aleksander W Krazinski; Felix G Meinel; U Joseph Schoepf; Justin R Silverman; Christian Canstein; Carlo N De Cecco; Lucas L Geyer Journal: Eur Radiol Date: 2014-07-24 Impact factor: 5.315
Authors: Nico Buls; Gert Van Gompel; Toon Van Cauteren; Koenraad Nieboer; Inneke Willekens; Guy Verfaillie; Paul Evans; Sven Macholl; Ben Newton; Johan de Mey Journal: Eur Radiol Date: 2014-11-29 Impact factor: 5.315