| Literature DB >> 20566767 |
Raimunda Sâmia Nogueira Brilhante1, Maria Auxiliadora Bezerra Fechine, Rossana de Aguiar Cordeiro, Marcos Fábio Gadelha Rocha, Joyce Fonteles Ribeiro, André Jalles Monteiro, Rita Amanda Chaves de Lima, Jacó Ricarte Lima Mesquita, Zoilo Pires de Camargo, José Júlio Costa Sidrim.
Abstract
This study evaluated the in vitro effect of sulfamethoxazole-trimethoprim against Histoplasma capsulatum var. capsulatum isolated from HIV-positive patients. The drugs were tested by microdilution testing in accordance with the CLSI guidelines. All of the strains were inhibited by sulfamethoxazole-trimethoprim, with MIC ranges of 0.039 (sulfamethoxazole)/0.0078 (trimethoprim) mg/ml to 0.625/0.125 mg/ml for mycelial forms and 0.0025/0.0005 to 0.02/0.004 mg/ml for yeast-like forms. However, in vivo studies are necessary to evaluate the significance of these results.Entities:
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Year: 2010 PMID: 20566767 PMCID: PMC2934947 DOI: 10.1128/AAC.00793-10
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191