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Literature DB >> 17472394

An approach to skeletal diversity using functional group pairing of multifunctional scaffolds.

Eamon Comer¹, Erin Rohan, Li Deng, John A Porco.

Abstract

Diversification of enantioenriched Michael adducts through functional group pairing to gain access to a range of five- to ten-membered complex fused and bridged ring systems is described.

Mesh：

Substances：
Hydrocarbons, Cyclic

Year: 2007 PMID： 17472394 DOI： 10.1021/ol070606t

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

33 in total

Review 1. Controlled microwave heating in modern organic synthesis: highlights from the 2004-2008 literature.

Authors: C Oliver Kappe; Doris Dallinger
Journal: Mol Divers Date: 2009-04-21 Impact factor: 2.943

2. Diversity-oriented synthesis of macrocyclic peptidomimetics.

Authors: Albert Isidro-Llobet; Tiffanie Murillo; Paula Bello; Agostino Cilibrizzi; James T Hodgkinson; Warren R J D Galloway; Andreas Bender; Martin Welch; David R Spring
Journal: Proc Natl Acad Sci U S A Date: 2011-03-07 Impact factor: 11.205

3. Synthesis of Diverse Heterocyclic Scaffolds via Tandem Additions to Imine Derivatives and Ring-Forming Reactions.

Authors: James D Sunderhaus; Chris Dockendorff; Stephen F Martin
Journal: Tetrahedron Date: 2009-09-15 Impact factor: 2.457

4. Diversity through a branched reaction pathway: generation of multicyclic scaffolds and identification of antimigratory agents.

Authors: Zhiming Wang; Sabrina Castellano; Sape S Kinderman; Christian E Argueta; Anwar B Beshir; Gabriel Fenteany; Ohyun Kwon
Journal: Chemistry Date: 2010-11-09 Impact factor: 5.236

5. Large-scale synthesis of all stereoisomers of a 2,3-unsaturated C-glycoside scaffold.

Authors: Baudouin Gerard; Jean-Charles Marié; Bhaumik A Pandya; Maurice D Lee; Haibo Liu; Lisa A Marcaurelle
Journal: J Org Chem Date: 2011-02-22 Impact factor: 4.354

6. Development of an automated microfluidic reaction platform for multidimensional screening: reaction discovery employing bicyclo[3.2.1]octanoid scaffolds.

Authors: John R Goodell; Jonathan P McMullen; Nikolay Zaborenko; Jason R Maloney; Chuan-Xing Ho; Klavs F Jensen; John A Porco; Aaron B Beeler
Journal: J Org Chem Date: 2009-08-21 Impact factor: 4.354

An approach to skeletal diversity using functional group pairing of multifunctional scaffolds.

Review 1. Controlled microwave heating in modern organic synthesis: highlights from the 2004-2008 literature.

2. Diversity-oriented synthesis of macrocyclic peptidomimetics.

3. Synthesis of Diverse Heterocyclic Scaffolds via Tandem Additions to Imine Derivatives and Ring-Forming Reactions.

4. Diversity through a branched reaction pathway: generation of multicyclic scaffolds and identification of antimigratory agents.

5. Large-scale synthesis of all stereoisomers of a 2,3-unsaturated C-glycoside scaffold.

6. Development of an automated microfluidic reaction platform for multidimensional screening: reaction discovery employing bicyclo[3.2.1]octanoid scaffolds.

7. Total Syntheses of Lyconadins: Finding Efficiency and Diversity.

8. Rapid, scalable assembly of stereochemically rich, mono- and bicyclic acyl sultams.

9. Applications of multicomponent reactions to the synthesis of diverse heterocyclic scaffolds.

10. Chiral squaramide derivatives are excellent hydrogen bond donor catalysts.