Literature DB >> 20559312

Drug discovery: Know your chemical space.

Andrew L Hopkins, G Richard Bickerton.   

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Year:  2010        PMID： 20559312     DOI： 10.1038/nchembio.395

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


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  8 in total

1.  Defining desirable central nervous system drug space through the alignment of molecular properties, in vitro ADME, and safety attributes.

Authors:  Travis T Wager; Ramalakshmi Y Chandrasekaran; Xinjun Hou; Matthew D Troutman; Patrick R Verhoest; Anabella Villalobos; Yvonne Will
Journal:  ACS Chem Neurosci       Date:  2010-03-25       Impact factor: 4.418

Review 2.  Navigating chemical space for biology and medicine.

Authors:  Christopher Lipinski; Andrew Hopkins
Journal:  Nature       Date:  2004-12-16       Impact factor: 49.962

3.  Global mapping of pharmacological space.

Authors:  Gaia V Paolini; Richard H B Shapland; Willem P van Hoorn; Jonathan S Mason; Andrew L Hopkins
Journal:  Nat Biotechnol       Date:  2006-07       Impact factor: 54.908

Review 4.  Drugs for bad bugs: confronting the challenges of antibacterial discovery.

Authors:  David J Payne; Michael N Gwynn; David J Holmes; David L Pompliano
Journal:  Nat Rev Drug Discov       Date:  2006-12-08       Impact factor: 84.694

5.  Physicochemical properties of antibacterial compounds: implications for drug discovery.

Authors:  Rosemarie O'Shea; Heinz E Moser
Journal:  J Med Chem       Date:  2008-02-09       Impact factor: 7.446

6.  A small-molecule screen in C. elegans yields a new calcium channel antagonist.

Authors:  Trevor C Y Kwok; Nicole Ricker; Regina Fraser; Allen W Chan; Andrew Burns; Elise F Stanley; Peter McCourt; Sean R Cutler; Peter J Roy
Journal:  Nature       Date:  2006-05-04       Impact factor: 49.962

7.  A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans.

Authors:  Andrew R Burns; Iain M Wallace; Jan Wildenhain; Mike Tyers; Guri Giaever; Gary D Bader; Corey Nislow; Sean R Cutler; Peter J Roy
Journal:  Nat Chem Biol       Date:  2010-05-30       Impact factor: 15.040

8.  Screening rules for leads of fungicides, herbicides, and insecticides.

Authors:  Bin Liu; Fucheng Zhu; Ying Huang; Yuhui Wang; Fei Yu; Botao Fan; Jianhua Yao
Journal:  J Agric Food Chem       Date:  2010-03-10       Impact factor: 5.279
  8 in total
  5 in total

Review 1.  Caenorhabditis elegans-based model systems for antifungal drug discovery.

Authors:  Cleo G Anastassopoulou; Beth Burgwyn Fuchs; Eleftherios Mylonakis
Journal:  Curr Pharm Des       Date:  2011       Impact factor: 3.116

2.  Discovery of an allosteric inhibitor binding site in 3-Oxo-acyl-ACP reductase from Pseudomonas aeruginosa.

Authors:  Cyprian D Cukier; Anthony G Hope; Ayssar A Elamin; Lucile Moynie; Robert Schnell; Susanne Schach; Holger Kneuper; Mahavir Singh; James H Naismith; Ylva Lindqvist; David W Gray; Gunter Schneider
Journal:  ACS Chem Biol       Date:  2013-09-23       Impact factor: 5.100

3.  Stereocontrolled Synthesis of Fluorinated Isochromans via Iodine(I)/Iodine(III) Catalysis.

Authors:  Joel Häfliger; Olga O Sokolova; Madina Lenz; Constantin G Daniliuc; Ryan Gilmour
Journal:  Angew Chem Int Ed Engl       Date:  2022-06-13       Impact factor: 16.823

4.  Regio- and Enantioselective Intermolecular Aminofluorination of Alkenes via Iodine(I)/Iodine(III) Catalysis.

Authors:  Michael Schäfer; Timo Stünkel; Constantin G Daniliuc; Ryan Gilmour
Journal:  Angew Chem Int Ed Engl       Date:  2022-06-28       Impact factor: 16.823

5.  Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma.

Authors:  Wilson Lim; Youri Melse; Mickey Konings; Hung Phat Duong; Kimberly Eadie; Benoît Laleu; Benjamin Perry; Matthew H Todd; Jean-Robert Ioset; Wendy W J van de Sande
Journal:  PLoS Negl Trop Dis       Date:  2018-04-26
  5 in total

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