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Literature DB >> 20558198

Roles of Vpr and Vpx in modulating the virus-host cell relationship.

Abstract

The human and simian immunodeficiency viruses contain small open reading frames known as vpr and vpx. These genes encode proteins that are highly related both at the amino acid level and functionally, although key differences do exist. This review describes the main functions ascribed to Vpr and Vpx in the context of both viral replication and modulation of host cell biology.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

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Year: 2010 PMID： 20558198 PMCID： PMC2967654 DOI： 10.1016/j.mam.2010.05.002

Source DB: PubMed Journal: Mol Aspects Med ISSN： 0098-2997

97 in total

Review 1. Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.

Authors: Jason L Dehart; Vicente Planelles
Journal: J Virol Date: 2007-09-12 Impact factor: 5.103

2. Vpx is critical for reverse transcription of the human immunodeficiency virus type 2 genome in macrophages.

Authors: Mikako Fujita; Masami Otsuka; Masami Miyoshi; Boonruang Khamsri; Masako Nomaguchi; Akio Adachi
Journal: J Virol Date: 2008-05-21 Impact factor: 5.103

Review 3. ATR: an essential regulator of genome integrity.

Authors: Karlene A Cimprich; David Cortez
Journal: Nat Rev Mol Cell Biol Date: 2008-07-02 Impact factor: 94.444

4. VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation.

Authors: J Huang; J Chen
Journal: Oncogene Date: 2008-03-10 Impact factor: 9.867

5. NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy.

Authors: Nadia Guerra; Ying Xim Tan; Nathalie T Joncker; Augustine Choy; Fermin Gallardo; Na Xiong; Susan Knoblaugh; Dragana Cado; Norman M Greenberg; Norman R Greenberg; David H Raulet
Journal: Immunity Date: 2008-04 Impact factor: 31.745

6. Localization of HIV-1 Vpr to the nuclear envelope: impact on Vpr functions and virus replication in macrophages.

Authors: Guillaume Jacquot; Erwann Le Rouzic; Annie David; Julie Mazzolini; Jérôme Bouchet; Serge Bouaziz; Florence Niedergang; Gianfranco Pancino; Serge Benichou
Journal: Retrovirology Date: 2007-11-26 Impact factor: 4.602

7. HIV-1 Vpr-mediated G2 arrest involves the DDB1-CUL4AVPRBP E3 ubiquitin ligase.

Authors: Jean-Philippe Belzile; Ghislaine Duisit; Nicole Rougeau; Johanne Mercier; Andrés Finzi; Eric A Cohen
Journal: PLoS Pathog Date: 2007-07 Impact factor: 6.823

8. Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection.

Authors: Smita Srivastava; Selene K Swanson; Nicolas Manel; Laurence Florens; Michael P Washburn; Jacek Skowronski
Journal: PLoS Pathog Date: 2008-05-09 Impact factor: 6.823

9. Lysis of endogenously infected CD4+ T cell blasts by rIL-2 activated autologous natural killer cells from HIV-infected viremic individuals.

Authors: Manuela Fogli; Domenico Mavilio; Enrico Brunetta; Stefania Varchetta; Khaled Ata; Gregg Roby; Colin Kovacs; Dean Follmann; Daniela Pende; Jeffrey Ward; Edward Barker; Emanuela Marcenaro; Alessandro Moretta; Anthony S Fauci
Journal: PLoS Pathog Date: 2008-07-11 Impact factor: 6.823

10. Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction.

Authors: Natalia Sharova; Yuanfei Wu; Xiaonan Zhu; Ruzena Stranska; Rajnish Kaushik; Mark Sharkey; Mario Stevenson
Journal: PLoS Pathog Date: 2008-05-02 Impact factor: 6.823

13 in total

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Authors: Mario Angelo Pagano; Elena Tibaldi; Giorgio Palù; Anna Maria Brunati
Journal: World J Virol Date: 2013-05-12

2. Damage control: how HIV survives the editor APOBEC3G.

Authors: J Ludovic Croxford; Stephan Gasser
Journal: Nat Immunol Date: 2011-09-20 Impact factor: 25.606

Review 3. Evasion from NK cell-mediated immune responses by HIV-1.

Authors: Stephanie Jost; Marcus Altfeld
Journal: Microbes Infect Date: 2012-05-21 Impact factor: 2.700

Review 4. Primate and feline lentiviruses in current intrinsic immunity research: the cat is back.

Authors: Eric M Poeschla
Journal: Vet Immunol Immunopathol Date: 2011-06-12 Impact factor: 2.046

Review 5. HIV-1 gag: an emerging target for antiretroviral therapy.

Authors: Philip R Tedbury; Eric O Freed
Journal: Curr Top Microbiol Immunol Date: 2015 Impact factor: 4.291

6. Reacquisition of Nef-mediated tetherin antagonism in a single in vivo passage of HIV-1 through its original chimpanzee host.

Authors: Nicola Götz; Daniel Sauter; Shariq M Usmani; Joëlle V Fritz; Christine Goffinet; Anke Heigele; Matthias Geyer; Frederic Bibollet-Ruche; Gerald H Learn; Oliver T Fackler; Beatrice H Hahn; Frank Kirchhoff
Journal: Cell Host Microbe Date: 2012-09-13 Impact factor: 21.023

Review 7. HIV accessory proteins versus host restriction factors.

Authors: Klaus Strebel
Journal: Curr Opin Virol Date: 2013-11-15 Impact factor: 7.090

8. Thriving under stress: selective translation of HIV-1 structural protein mRNA during Vpr-mediated impairment of eIF4E translation activity.

Authors: Amit Sharma; Alper Yilmaz; Kim Marsh; Alan Cochrane; Kathleen Boris-Lawrie
Journal: PLoS Pathog Date: 2012-03-22 Impact factor: 6.823

Review 9. HIV-1 replication and the cellular eukaryotic translation apparatus.

Authors: Santiago Guerrero; Julien Batisse; Camille Libre; Serena Bernacchi; Roland Marquet; Jean-Christophe Paillart
Journal: Viruses Date: 2015-01-19 Impact factor: 5.048

10. HIV-1 Vpr induces the degradation of ZIP and sZIP, adaptors of the NuRD chromatin remodeling complex, by hijacking DCAF1/VprBP.

Authors: Claire Maudet; Adèle Sourisce; Loïc Dragin; Hichem Lahouassa; Jean-Christophe Rain; Serge Bouaziz; Bertha Cécilia Ramirez; Florence Margottin-Goguet
Journal: PLoS One Date: 2013-10-08 Impact factor: 3.240