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Literature DB >> 21934670

Damage control: how HIV survives the editor APOBEC3G.

Abstract

The antiviral factor APOBEC3G upregulates the expression of ligands for the activating receptor NKG2D via DNA damage induced by the viral protein Vpr in cells infected with human immunodeficiency virus. The virus overcomes greater susceptibility to natural killer cell–mediated lysis by targeting APOBEC3G for degradation.

Entities: Gene Species

Mesh：

Substances：

Year: 2011 PMID： 21934670 DOI： 10.1038/ni.2115

Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 25.606

11 in total

Review 1. The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements.

Authors: Ya-Lin Chiu; Warner C Greene
Journal: Annu Rev Immunol Date: 2008 Impact factor: 28.527

2. Enhancing immunity to HIV through APOBEC.

Authors: Reuben S Harris
Journal: Nat Biotechnol Date: 2008-10 Impact factor: 54.908

Review 3. DCs and NK cells: critical effectors in the immune response to HIV-1.

Authors: Marcus Altfeld; Lena Fadda; Davor Frleta; Nina Bhardwaj
Journal: Nat Rev Immunol Date: 2011-03 Impact factor: 53.106

4. The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor.

Authors: Stephan Gasser; Sandra Orsulic; Eric J Brown; David H Raulet
Journal: Nature Date: 2005-07-03 Impact factor: 49.962

Review 5. Roles of Vpr and Vpx in modulating the virus-host cell relationship.

Authors: Vicente Planelles; Edward Barker
Journal: Mol Aspects Med Date: 2010-06-15

6. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.

Authors: Almudena R Ramiro; Mila Jankovic; Elsa Callen; Simone Difilippantonio; Hua-Tang Chen; Kevin M McBride; Thomas R Eisenreich; Junjie Chen; Ross A Dickins; Scott W Lowe; Andre Nussenzweig; Michel C Nussenzweig
Journal: Nature Date: 2006-01-08 Impact factor: 49.962

7. MHC class I chain-related protein A shedding in chronic HIV-1 infection is associated with profound NK cell dysfunction.

Authors: Anne Nolting; Anne-Sophie Dugast; Suzannah Rihn; Rutger Luteijn; Mary F Carrington; Katherine Kane; Stephanie Jost; Ildiko Toth; Ellen Nagami; Gerd Faetkenheuer; Pia Hartmann; Marcus Altfeld; Galit Alter
Journal: Virology Date: 2010-07-29 Impact factor: 3.616

Damage control: how HIV survives the editor APOBEC3G.

Review 1. The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements.

2. Enhancing immunity to HIV through APOBEC.

Review 3. DCs and NK cells: critical effectors in the immune response to HIV-1.

4. The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor.

Review 5. Roles of Vpr and Vpx in modulating the virus-host cell relationship.

6. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.

7. MHC class I chain-related protein A shedding in chronic HIV-1 infection is associated with profound NK cell dysfunction.

8. Human immunodeficiency virus type 1 Vpr modulates cellular expression of UNG2 via a negative transcriptional effect.

9. Cytidine deamination induced HIV-1 drug resistance.

10. The antiviral factor APOBEC3G enhances the recognition of HIV-infected primary T cells by natural killer cells.

1. APOBEC3 versus Retroviruses, Immunity versus Invasion: Clash of the Titans.

Review 2. Molecular mechanisms of HIV immune evasion of the innate immune response in myeloid cells.