Literature DB >> 20554355

Synthesis and evaluation of graveoline and graveolinine derivatives with potent anti-angiogenesis activities.

Zeng-Yun An1, Yi-Yong Yan, Dan Peng, Tian-Miao Ou, Jia-Heng Tan, Shi-Liang Huang, Lin-Kun An, Lian-Quan Gu, Zhi-Shu Huang.   

Abstract

A series of graveoline and graveolinine derivatives were synthesized. The biological results showed that most of graveoline derivatives possessed higher cytotoxicity and better inhibitive effect against the adhesion and migration of human umbilical vein endothelial cell (HUVEC) than graveolinine derivatives. Among these compounds, 8d was the most potent agents that also showed significant anti-angiogenesis activities in chick embryo chorioallantoic membrane (CAM) assay. 2010 Elsevier Masson SAS. All rights reserved.

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Year:  2010        PMID： 20554355     DOI： 10.1016/j.ejmech.2010.05.043

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  4 in total

1.  (E)-2-[2-(4-Chloro-benzyl-idene)hydrazin-yl]-4-[3-(morpholin-4-ium-4-yl)propyl-amino]-quinazolin-1-ium bis-(perchlorate).

Authors:  Nan Jiang; Jian Zuo; Wenmin Zhu; Xinjie Zhao; Xin Zhai
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-05-19

2.  (E)-2-[2-(4-Chloro-benzyl-idene)hydrazin-1-yl]-4-{[3-(dimethyl-aza-nium-yl)prop-yl]amino}-quinazolin-1-ium bis-(perchlorate).

Authors:  Nan Jiang; Jian Zuo; Haiyan Wang; Ming Han; Xin Zhai
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-04-28

3.  Chalepin: A Compound from Ruta angustifolia L. Pers Exhibits Cell Cycle Arrest at S phase, Suppresses Nuclear Factor-Kappa B (NF-κB) Pathway, Signal Transducer and Activation of Transcription 3 (STAT3) Phosphorylation and Extrinsic Apoptotic Pathway in Non-small Cell Lung Cancer Carcinoma (A549).

Authors:  Jaime Stella Moses Richardson; Norhaniza Aminudin; Sri Nurestri Abd Malek
Journal:  Pharmacogn Mag       Date:  2017-10-11       Impact factor: 1.085

4.  Design, synthesis and antiproliferative activity of novel 2-substituted-4-amino-6-halogenquinolines.

Authors:  Nan Jiang; Xin Zhai; Ting Li; Difa Liu; Tingting Zhang; Bin Wang; Ping Gong
Journal:  Molecules       Date:  2012-05-16       Impact factor: 4.411
  4 in total

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