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Literature DB >> 20550123

Bioactive 1,4-dihydroxy-5-phenyl-2-pyridinone alkaloids from Septoria pistaciarum.

Mallika Kumarihamy¹, Frank R Fronczek, Daneel Ferreira, Melissa Jacob, Shabana I Khan, N P Dhammika Nanayakkara.

Abstract

Four new 1,4-dihydroxy-5-phenyl-2-pyridinone alkaloids (1-4) were isolated from an EtOAc extract of a culture medium of Septoria pistaciarum. The structures of these compounds were determined by spectroscopic methods, and the absolute configuration of the major compound (1) was determined by X-ray crystallographic analysis. Compound 1 exhibited moderate in vitro antiplasmodial (antimalarial) activity against chloroquine-sensitive (D6) and -resistant (W2) strains of Plasmodium falciparum and cytotoxic activity to Vero cells. Compound 2 was moderately active against both methicillin-sensitive and methicillin-resistant strains of Staphylococcus aureus.

Entities: CellLine Chemical Disease Gene Species

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Year: 2010 PMID： 20550123 PMCID： PMC2917538 DOI： 10.1021/np1000939

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

14 in total

1. Structures of cordypyridones A-D, antimalarial N-hydroxy- and N-methoxy-2-pyridones from the insect pathogenic fungus Cordyceps nipponica.

Authors: M Isaka; M Tanticharoen; P Kongsaeree; Y Thebtaranonth
Journal: J Org Chem Date: 2001-07-13 Impact factor: 4.354

Review 2. Phytotoxins produced by microbial plant pathogens.

Authors: Richard N Strange
Journal: Nat Prod Rep Date: 2006-11-28 Impact factor: 13.423

3. N-Methyl-4-hydroxy-2-pyridinone analogues from Fusarium oxysporum.

Authors: Lalith Jayasinghe; Hamed K Abbas; Melissa R Jacob; Wimal H M W Herath; N P Dhammika Nanayakkara
Journal: J Nat Prod Date: 2006-03 Impact factor: 4.050

4. Novel tetramic acids and pyridone alkaloids, militarinones B, C, and D, from the insect pathogenic fungus Paecilomyces militaris.

Authors: Karen Schmidt; Ulrike Riese; Zengzhi Li; Matthias Hamburger
Journal: J Nat Prod Date: 2003-03 Impact factor: 4.050

Bioactive 1,4-dihydroxy-5-phenyl-2-pyridinone alkaloids from Septoria pistaciarum.

1. Structures of cordypyridones A-D, antimalarial N-hydroxy- and N-methoxy-2-pyridones from the insect pathogenic fungus Cordyceps nipponica.

Review 2. Phytotoxins produced by microbial plant pathogens.

3. N-Methyl-4-hydroxy-2-pyridinone analogues from Fusarium oxysporum.

4. Novel tetramic acids and pyridone alkaloids, militarinones B, C, and D, from the insect pathogenic fungus Paecilomyces militaris.

5. Farinosones A-C, neurotrophic alkaloidal metabolites from the entomogenous deuteromycete Paecilomyces farinosus.

6. Antiprotozoal and antimicrobial activities of O-alkylated and formylated acylphloroglucinols.

7. A survey of synthetic and natural phytotoxic compounds and phytoalexins as potential antimalarial compounds.

8. Antimicrobial, antiparasitic and cytotoxic spermine alkaloids from Albizia schimperiana.

9. Funiculosin, a new antibiotic. II. Structure elucidation and antifungal activity.

10. Determination of absolute structure using Bayesian statistics on Bijvoet differences.

1. Antiprotozoal and antimicrobial compounds from the plant pathogen Septoria pistaciarum.

Review 2. Antiplasmodial natural products: an update.

3. Synthesis and biological evaluation of 2-oxonicotinonitriles and 2-oxonicotinonitrile based nucleoside analogues.