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Literature DB >> 681235

Funiculosin, a new antibiotic. II. Structure elucidation and antifungal activity.

K Ando, I Matsuura, Y Nawata, H Endo, H Sasaki, T Okytomi, T Saehi, G Tamura.

Abstract

Structure elucidation and some biological properties of an antiviral and antifungal antibiotic, funiculosin, are summarized. Funiculosin is a derivative of N-methyl-4-hydroxy-3, 5-disubstituted-2-pyridone containing a novel substituent, cyclopentanetetrol moiety, that is reported here for the first time in a natural product. The antibiotic protects guinea pigs efficiently against experimental trichophytosis. Toxicity of funiculosin is unique and highly selective for animal species.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1978 PMID： 681235 DOI： 10.7164/antibiotics.31.533

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Cited

4 in total

1. Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex.

Authors: Naoki Okamoto; Keisuke Mizote; Hiroe Honda; Akinori Saeki; Yasuharu Watanabe; Tomomi Yamaguchi-Miyamoto; Ryutaro Fukui; Natsuko Tanimura; Yuji Motoi; Sachiko Akashi-Takamura; Tatsuhisa Kato; Shigeto Fujishita; Takahito Kimura; Umeharu Ohto; Toshiyuki Shimizu; Takatsugu Hirokawa; Kensuke Miyake; Koichi Fukase; Yukari Fujimoto; Yoshinori Nagai; Kiyoshi Takatsu
Journal: J Biol Chem Date: 2017-07-28 Impact factor: 5.157

Funiculosin, a new antibiotic. II. Structure elucidation and antifungal activity.

1. Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex.

2. Bioactive 1,4-dihydroxy-5-phenyl-2-pyridinone alkaloids from Septoria pistaciarum.

3. Catalytic Reactions and Energy Conservation in the Cytochrome bc₁ and b₆f Complexes of Energy-Transducing Membranes.

4. Two New Compounds Containing Pyridinone or Triazine Heterocycles Have Antifungal Properties against Candida albicans.

Funiculosin, a new antibiotic. II. Structure elucidation and antifungal activity.

1. Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex.

2. Bioactive 1,4-dihydroxy-5-phenyl-2-pyridinone alkaloids from Septoria pistaciarum.

3. Catalytic Reactions and Energy Conservation in the Cytochrome bc1 and b6f Complexes of Energy-Transducing Membranes.

4. Two New Compounds Containing Pyridinone or Triazine Heterocycles Have Antifungal Properties against Candida albicans.

3. Catalytic Reactions and Energy Conservation in the Cytochrome bc₁ and b₆f Complexes of Energy-Transducing Membranes.