Literature DB >> 20546803

Purified Plasmodium falciparum multi-drug resistance protein (PfMDR 1) binds a high affinity chloroquine analogue.

Perri Pleeter1, Jacqueline K Lekostaj, Paul D Roepe.   

Abstract

We utilize the recent successful overexpression of recombinant Plasmodium falciparum multi-drug resistance transporter, purification and reconstitution of the protein, and a novel high affinity chloroquine analogue to probe hypothesized interaction between the transporter and quinoline drugs. Results suggest that PfMDR1 binding sites for chloroquine, mefloquine, and quinine overlap, that P. falciparum chloroquine resistance transporter has intrinsically higher affinity for chloroquine relative to P. falciparum multi-drug resistance transporter, and that there is an isoform specific competition between the two transporters for binding of quinoline antimalarial drugs. Copyright 2010 Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 20546803      PMCID： PMC2906614          DOI： 10.1016/j.molbiopara.2010.05.012

Source DB:  PubMed          Journal:  Mol Biochem Parasitol        ISSN： 0166-6851            Impact factor:   1.759


  21 in total

1.  Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance.

Authors:  D A Fidock; T Nomura; A K Talley; R A Cooper; S M Dzekunov; M T Ferdig; L M Ursos; A B Sidhu; B Naudé; K W Deitsch; X Z Su; J C Wootton; P D Roepe; T E Wellems
Journal:  Mol Cell       Date:  2000-10       Impact factor: 17.970

Review 2.  Chloroquine-resistant malaria.

Authors:  T E Wellems; C V Plowe
Journal:  J Infect Dis       Date:  2001-08-07       Impact factor: 5.226

3.  Characterization of the azidopine and vinblastine binding site of P-glycoprotein.

Authors:  E P Bruggemann; S J Currier; M M Gottesman; I Pastan
Journal:  J Biol Chem       Date:  1992-10-15       Impact factor: 5.157

4.  Major photoaffinity drug labeling sites for iodoaryl azidoprazosin in P-glycoprotein are within, or immediately C-terminal to, transmembrane domains 6 and 12.

Authors:  L M Greenberger
Journal:  J Biol Chem       Date:  1993-05-25       Impact factor: 5.157

5.  Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.

Authors:  Stephen G Aller; Jodie Yu; Andrew Ward; Yue Weng; Srinivas Chittaboina; Rupeng Zhuo; Patina M Harrell; Yenphuong T Trinh; Qinghai Zhang; Ina L Urbatsch; Geoffrey Chang
Journal:  Science       Date:  2009-03-27       Impact factor: 47.728

6.  Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross.

Authors:  T E Wellems; L J Panton; I Y Gluzman; V E do Rosario; R W Gwadz; A Walker-Jonah; D J Krogstad
Journal:  Nature       Date:  1990-05-17       Impact factor: 49.962

7.  Purified human MDR 1 modulates membrane potential in reconstituted proteoliposomes.

Authors:  Ellen M Howard; Paul D Roepe
Journal:  Biochemistry       Date:  2003-04-01       Impact factor: 3.162

8.  Chloroquine transport in Plasmodium falciparum. 2. Analysis of PfCRT-mediated drug transport using proteoliposomes and a fluorescent chloroquine probe.

Authors:  Michelle F Paguio; Mynthia Cabrera; Paul D Roepe
Journal:  Biochemistry       Date:  2009-10-13       Impact factor: 3.162

9.  Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum.

Authors:  C M Wilson; A E Serrano; A Wasley; M P Bogenschutz; A H Shankar; D F Wirth
Journal:  Science       Date:  1989-06-09       Impact factor: 47.728

10.  A P-glycoprotein homologue of Plasmodium falciparum is localized on the digestive vacuole.

Authors:  A F Cowman; S Karcz; D Galatis; J G Culvenor
Journal:  J Cell Biol       Date:  1991-06       Impact factor: 10.539
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  15 in total

1.  UV-triggered affinity capture identifies interactions between the Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) and antimalarial agents in live parasitized cells.

Authors:  Ralf Brunner; Caroline L Ng; Hamed Aissaoui; Myles H Akabas; Christoph Boss; Reto Brun; Paul S Callaghan; Olivier Corminboeuf; David A Fidock; Ithiel J Frame; Bibia Heidmann; Amélie Le Bihan; Paul Jenö; Corinna Mattheis; Suzette Moes; Ingrid B Müller; Michelle Paguio; Paul D Roepe; Romain Siegrist; Till Voss; Richard W D Welford; Sergio Wittlin; Christoph Binkert
Journal:  J Biol Chem       Date:  2013-06-10       Impact factor: 5.157

2.  Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity.

Authors:  Manu Vanaerschot; Leonardo Lucantoni; Tao Li; Jill M Combrinck; Andrea Ruecker; T R Santha Kumar; Kelly Rubiano; Pedro E Ferreira; Giulia Siciliano; Sonia Gulati; Philipp P Henrich; Caroline L Ng; James M Murithi; Victoria C Corey; Sandra Duffy; Ori J Lieberman; M Isabel Veiga; Robert E Sinden; Pietro Alano; Michael J Delves; Kim Lee Sim; Elizabeth A Winzeler; Timothy J Egan; Stephen L Hoffman; Vicky M Avery; David A Fidock
Journal:  Nat Microbiol       Date:  2017-08-14       Impact factor: 17.745

3.  Analysis of chloroquine resistance transporter (CRT) isoforms and orthologues in S. cerevisiae yeast.

Authors:  Nicholas K Baro; Chaya Pooput; Paul D Roepe
Journal:  Biochemistry       Date:  2011-07-19       Impact factor: 3.162

Review 4.  PfCRT-mediated drug transport in malarial parasites.

Authors:  Paul D Roepe
Journal:  Biochemistry       Date:  2010-12-22       Impact factor: 3.162

5.  Investigating the activity of quinine analogues versus chloroquine resistant Plasmodium falciparum.

Authors:  Theresa Dinio; Alexander P Gorka; Andrew McGinniss; Paul D Roepe; Jeremy B Morgan
Journal:  Bioorg Med Chem       Date:  2012-03-29       Impact factor: 3.641

6.  Chloroquine susceptibility and reversibility in a Plasmodium falciparum genetic cross.

Authors:  Jigar J Patel; Drew Thacker; John C Tan; Perri Pleeter; Lisa Checkley; Joseph M Gonzales; Bingbing Deng; Paul D Roepe; Roland A Cooper; Michael T Ferdig
Journal:  Mol Microbiol       Date:  2010-09-29       Impact factor: 3.501

7.  Plasmodium falciparum resistance to cytocidal versus cytostatic effects of chloroquine.

Authors:  Michelle F Paguio; Kelly L Bogle; Paul D Roepe
Journal:  Mol Biochem Parasitol       Date:  2011-04-04       Impact factor: 1.759

8.  Function of resistance conferring Plasmodium falciparum chloroquine resistance transporter isoforms.

Authors:  Nicholas K Baro; Paul S Callaghan; Paul D Roepe
Journal:  Biochemistry       Date:  2013-06-06       Impact factor: 3.162

9.  Mechanistic basis for multidrug resistance and collateral drug sensitivity conferred to the malaria parasite by polymorphisms in PfMDR1 and PfCRT.

Authors:  Sarah Heckmatt Shafik; Sashika Natasha Richards; Ben Corry; Rowena Elizabeth Martin
Journal:  PLoS Biol       Date:  2022-05-04       Impact factor: 9.593

10.  A process similar to autophagy is associated with cytocidal chloroquine resistance in Plasmodium falciparum.

Authors:  David Gaviria; Michelle F Paguio; Lindsey B Turnbull; Asako Tan; Amila Siriwardana; Debasish Ghosh; Michael T Ferdig; Anthony P Sinai; Paul D Roepe
Journal:  PLoS One       Date:  2013-11-20       Impact factor: 3.240
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