Literature DB >> 23688277

Function of resistance conferring Plasmodium falciparum chloroquine resistance transporter isoforms.

Nicholas K Baro1, Paul S Callaghan, Paul D Roepe.   

Abstract

The function of Plasmodium falciparum chloroquine resistance transporter (PfCRT) can be quantified using a Saccharomyces cerevisiae model system [Baro, N. K., Pooput, C., and Roepe, P. D. (2011) Biochemistry 50, 6701-6710]. We further optimized this system to distinguish PfCRT isoforms found in P. falciparum strains and isolates from across the globe. We created and expressed 13 naturally occurring pfcrt alleles associated with a range of chloroquine resistant (CQR) phenotypes. Using galactose induction of PfCRT, we quantified PfCRT and chloroquine (CQ)-dependent yeast growth inhibition and [3H]CQ transport specifically due to a given PfCRT isoform. Surprisingly, we found poor correlation between these parameters and the CQ IC50 observed in strains of malaria harboring the same isoforms. This suggested that an increased level of CQ transport due to PfCRT mutation is necessary, but not sufficient, for the range of CQ IC50 values observed in globally distributed CQR P. falciparum isolates.

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Year:  2013        PMID： 23688277      PMCID： PMC3703759          DOI： 10.1021/bi400557x

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  40 in total

1.  Sequence polymorphisms in pfcrt are strongly associated with chloroquine resistance in Plasmodium falciparum.

Authors:  N Chen; B Russell; J Staley; B Kotecka; P Nasveld; Q Cheng
Journal:  J Infect Dis       Date:  2001-05-15       Impact factor: 5.226

2.  pfcrt Allelic types with two novel amino acid mutations in chloroquine-resistant Plasmodium falciparum isolates from the Philippines.

Authors:  Nanhua Chen; Dennis E Kyle; Cielo Pasay; Elizabeth V Fowler; Joanne Baker; Jennifer M Peters; Qin Cheng
Journal:  Antimicrob Agents Chemother       Date:  2003-11       Impact factor: 5.191

3.  Drug resistance-associated pfCRT mutations confer decreased Plasmodium falciparum digestive vacuolar pH.

Authors:  Tyler N Bennett; Andrew D Kosar; Lyann M B Ursos; Sergey Dzekunov; Amar Bir Singh Sidhu; David A Fidock; Paul D Roepe
Journal:  Mol Biochem Parasitol       Date:  2004-01       Impact factor: 1.759

4.  New haplotypes of the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene among chloroquine-resistant parasite isolates.

Authors:  Hadya S Nagesha; Gerard J Casey; Karl H Rieckmann; David J Fryauff; Budi S Laksana; John C Reeder; Jason D Maguire; J Kevin Baird
Journal:  Am J Trop Med Hyg       Date:  2003-04       Impact factor: 2.345

5.  Characterization of genes that are synthetically lethal with ade3 or leu2 in Saccharomyces cerevisiae.

Authors:  Shraddha S Nigavekar; John F Cannon
Journal:  Yeast       Date:  2002-01-30       Impact factor: 3.239

6.  Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America.

Authors:  R K Mehlotra; H Fujioka; P D Roepe; O Janneh; L M Ursos; V Jacobs-Lorena; D T McNamara; M J Bockarie; J W Kazura; D E Kyle; D A Fidock; P A Zimmerman
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-23       Impact factor: 11.205

7.  Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum.

Authors:  John C Wootton; Xiaorong Feng; Michael T Ferdig; Roland A Cooper; Jianbing Mu; Dror I Baruch; Alan J Magill; Xin-Zhuan Su
Journal:  Nature       Date:  2002-07-18       Impact factor: 49.962

8.  Dissecting the loci of low-level quinine resistance in malaria parasites.

Authors:  Michael T Ferdig; Roland A Cooper; Jianbing Mu; Bingbing Deng; Deirdre A Joy; Xin-zhuan Su; Thomas E Wellems
Journal:  Mol Microbiol       Date:  2004-05       Impact factor: 3.501

9.  Multiple transporters associated with malaria parasite responses to chloroquine and quinine.

Authors:  Jianbing Mu; Michael T Ferdig; Xiaorong Feng; Deirdre A Joy; Junhui Duan; Tetsuya Furuya; G Subramanian; L Aravind; Roland A Cooper; John C Wootton; Momiao Xiong; Xin-zhuan Su
Journal:  Mol Microbiol       Date:  2003-08       Impact factor: 3.501

10.  Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations.

Authors:  Amar Bir Singh Sidhu; Dominik Verdier-Pinard; David A Fidock
Journal:  Science       Date:  2002-10-04       Impact factor: 47.728
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  20 in total

1.  Signaling of chloroquine-induced stress in the yeast Saccharomyces cerevisiae requires the Hog1 and Slt2 mitogen-activated protein kinase pathways.

Authors:  Shivani Baranwal; Gajendra Kumar Azad; Vikash Singh; Raghuvir S Tomar
Journal:  Antimicrob Agents Chemother       Date:  2014-07-14       Impact factor: 5.191

2.  Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter.

Authors:  Ines Petersen; Stanislaw J Gabryszewski; Geoffrey L Johnston; Satish K Dhingra; Andrea Ecker; Rebecca E Lewis; Mariana Justino de Almeida; Judith Straimer; Philipp P Henrich; Eugene Palatulan; David J Johnson; Olivia Coburn-Flynn; Cecilia Sanchez; Adele M Lehane; Michael Lanzer; David A Fidock
Journal:  Mol Microbiol       Date:  2015-05-20       Impact factor: 3.501

3.  Functional Comparison of 45 Naturally Occurring Isoforms of the Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT).

Authors:  Paul S Callaghan; Matthew R Hassett; Paul D Roepe
Journal:  Biochemistry       Date:  2015-08-06       Impact factor: 3.162

4.  Overcoming Chloroquine Resistance in Malaria: Design, Synthesis, and Structure-Activity Relationships of Novel Hybrid Compounds.

Authors:  Aicha Boudhar; Xiao Wei Ng; Chiew Yee Loh; Wan Ni Chia; Zhi Ming Tan; Francois Nosten; Brian W Dymock; Kevin S W Tan
Journal:  Antimicrob Agents Chemother       Date:  2016-04-22       Impact factor: 5.191

5.  Role of Pfmdr1 in in vitro Plasmodium falciparum susceptibility to chloroquine, quinine, monodesethylamodiaquine, mefloquine, lumefantrine, and dihydroartemisinin.

Authors:  Nathalie Wurtz; Bécaye Fall; Aurélie Pascual; Mansour Fall; Eric Baret; Cheikhou Camara; Aminata Nakoulima; Bakary Diatta; Khadidiatou Ba Fall; Pape Saliou Mbaye; Yaya Diémé; Raymond Bercion; Boubacar Wade; Bruno Pradines
Journal:  Antimicrob Agents Chemother       Date:  2014-09-08       Impact factor: 5.191

6.  To kill or not to kill, that is the question: cytocidal antimalarial drug resistance.

Authors:  Paul D Roepe
Journal:  Trends Parasitol       Date:  2014-02-13

7.  Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities.

Authors:  Serena Pulcini; Henry M Staines; Andrew H Lee; Sarah H Shafik; Guillaume Bouyer; Catherine M Moore; Daniel A Daley; Matthew J Hoke; Lindsey M Altenhofen; Heather J Painter; Jianbing Mu; David J P Ferguson; Manuel Llinás; Rowena E Martin; David A Fidock; Roland A Cooper; Sanjeev Krishna
Journal:  Sci Rep       Date:  2015-09-30       Impact factor: 4.379

8.  "Drug resistance associated membrane proteins".

Authors:  Katy S Sherlach; Paul D Roepe
Journal:  Front Physiol       Date:  2014-03-20       Impact factor: 4.566

9.  High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations.

Authors:  Bryan T Mott; Richard T Eastman; Rajarshi Guha; Katy S Sherlach; Amila Siriwardana; Paul Shinn; Crystal McKnight; Sam Michael; Norinne Lacerda-Queiroz; Paresma R Patel; Pwint Khine; Hongmao Sun; Monica Kasbekar; Nima Aghdam; Shaun D Fontaine; Dongbo Liu; Tim Mierzwa; Lesley A Mathews-Griner; Marc Ferrer; Adam R Renslo; James Inglese; Jing Yuan; Paul D Roepe; Xin-Zhuan Su; Craig J Thomas
Journal:  Sci Rep       Date:  2015-09-25       Impact factor: 4.379

10.  A process similar to autophagy is associated with cytocidal chloroquine resistance in Plasmodium falciparum.

Authors:  David Gaviria; Michelle F Paguio; Lindsey B Turnbull; Asako Tan; Amila Siriwardana; Debasish Ghosh; Michael T Ferdig; Anthony P Sinai; Paul D Roepe
Journal:  PLoS One       Date:  2013-11-20       Impact factor: 3.240
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