PURPOSE OF REVIEW: An estimated 33 million people are living with HIV and universal access remains a dream for millions of people. By the end of year 2008, four million people were on treatment; however, over five million needed treatment, and in 2007, there were 2.7 million new infections. Without significant improvement in prevention, we are unlikely to meet universal access targets including the growing demand for highly active antiretroviral treatment (HAART). This review examines HAART as a potential tool for preventing HIV transmission. RECENT FINDINGS: We discuss recent scientific evidence regarding the treatment and prevention gap, importance viral load and HIV transmission, HAART and HIV transmission, when to start, HIV counseling and testing, modeling results and next steps. SUMMARY: HAART has considerable treatment and prevention benefits and it needs to be considered as a key element of combination prevention. To explore HAART as an effective prevention strategy, we recommend further evaluation of human rights and ethical considerations, clarification of research priorities and exploration of feasibility and acceptability issues.
PURPOSE OF REVIEW: An estimated 33 million people are living with HIV and universal access remains a dream for millions of people. By the end of year 2008, four million people were on treatment; however, over five million needed treatment, and in 2007, there were 2.7 million new infections. Without significant improvement in prevention, we are unlikely to meet universal access targets including the growing demand for highly active antiretroviral treatment (HAART). This review examines HAART as a potential tool for preventing HIV transmission. RECENT FINDINGS: We discuss recent scientific evidence regarding the treatment and prevention gap, importance viral load and HIV transmission, HAART and HIV transmission, when to start, HIV counseling and testing, modeling results and next steps. SUMMARY: HAART has considerable treatment and prevention benefits and it needs to be considered as a key element of combination prevention. To explore HAART as an effective prevention strategy, we recommend further evaluation of human rights and ethical considerations, clarification of research priorities and exploration of feasibility and acceptability issues.
Authors: Julio S G Montaner; Robert Hogg; Evan Wood; Thomas Kerr; Mark Tyndall; Adrian R Levy; P Richard Harrigan Journal: Lancet Date: 2006-08-05 Impact factor: 79.321
Authors: Silvia Bertagnolio; Inge Derdelinckx; Monica Parker; Joseph Fitzgibbon; Herve Fleury; Martin Peeters; Rob Schuurman; Deenan Pillay; Lynn Morris; Amilcar Tanuri; Guy-Michel Gershy-Damet; John Nkengasong; Charles F Gilks; Donald Sutherland; Paul Sandstrom Journal: Antivir Ther Date: 2008
Authors: Rochelle P Walensky; Robin Wood; Milton C Weinstein; Neil A Martinson; Elena Losina; Mariam O Fofana; Sue J Goldie; Nomita Divi; Yazdan Yazdanpanah; Bingxia Wang; A David Paltiel; Kenneth A Freedberg Journal: J Infect Dis Date: 2008-05-01 Impact factor: 5.226
Authors: Jens D Lundgren; Abdel Babiker; Wafaa El-Sadr; Sean Emery; Birgit Grund; James D Neaton; Jacquie Neuhaus; Andrew N Phillips Journal: J Infect Dis Date: 2008-04-15 Impact factor: 5.226
Authors: Jeffrey H Herbst; Marlene Glassman; James W Carey; Thomas M Painter; Deborah J Gelaude; Amy M Fasula; Jerris L Raiford; Arin E Freeman; Camilla Harshbarger; Abigail H Viall; David W Purcell Journal: J Acquir Immune Defic Syndr Date: 2012-04-15 Impact factor: 3.731
Authors: Xiao Zang; Emanuel Krebs; Linwei Wang; Brandon D L Marshall; Reuben Granich; Bruce R Schackman; Julio S G Montaner; Bohdan Nosyk Journal: Pharmacoeconomics Date: 2019-10 Impact factor: 4.981
Authors: Seth C Kalichman; Chauncey Cherry; Denise White; Miche'l Jones; Tamar Grebler; Moira O Kalichman; Mervi Detorio; Angela M Caliendo; Raymond F Schinazi Journal: Ann Behav Med Date: 2011-08
Authors: Kathleen J Sikkema; Laurie Abler; Nathan B Hansen; Patrick A Wilson; Anya S Drabkin; Arlene Kochman; Jessica C MacFarlane; Allyson DeLorenzo; Gal Mayer; Melissa H Watt; William Nazareth Journal: AIDS Behav Date: 2014-09