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Literature DB >> 21841072

New insights into HIV assembly and trafficking.

Muthukumar Balasubramaniam¹, Eric O Freed.

Abstract

Assembly and release of human immunodeficiency virus type 1 (HIV-1) particles is mediated by the viral Gag polyprotein precursor. Gag is synthesized in the cytosol and rapidly translocates to membrane to orchestrate particle production. The cell biology of HIV-1 Gag trafficking is currently one of the least understood aspects of HIV-1 replication. In this review, we highlight the current understanding of the cellular machinery involved in Gag trafficking and virus assembly.

Entities: CellLine Chemical Disease Gene Species

Mesh：

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Year: 2011 PMID： 21841072 PMCID： PMC3467973 DOI： 10.1152/physiol.00051.2010

Source DB: PubMed Journal: Physiology (Bethesda) ISSN： 1548-9221

244 in total

1. Entropic switch regulates myristate exposure in the HIV-1 matrix protein.

Authors: Chun Tang; Erin Loeliger; Paz Luncsford; Isaac Kinde; Dorothy Beckett; Michael F Summers
Journal: Proc Natl Acad Sci U S A Date: 2003-12-29 Impact factor: 11.205

2. HIV-1 egress is gated through late endosomal membranes.

Authors: Sascha Nydegger; Michelangelo Foti; Aaron Derdowski; Paul Spearman; Markus Thali
Journal: Traffic Date: 2003-12 Impact factor: 6.215

3. The ESCRT pathway and HIV-1 budding.

Authors: Yoshiko Usami; Sergei Popov; Elena Popova; Michio Inoue; Winfried Weissenhorn; Heinrich G Göttlinger
Journal: Biochem Soc Trans Date: 2009-02 Impact factor: 5.407

4. Opposing mechanisms involving RNA and lipids regulate HIV-1 Gag membrane binding through the highly basic region of the matrix domain.

Authors: Vineela Chukkapalli; Seung J Oh; Akira Ono
Journal: Proc Natl Acad Sci U S A Date: 2010-01-04 Impact factor: 11.205

5. Conservation of a stepwise, energy-sensitive pathway involving HP68 for assembly of primate lentivirus capsids in cells.

Authors: Julia E Dooher; Jaisri R Lingappa
Journal: J Virol Date: 2004-02 Impact factor: 5.103

6. Distinct intracellular trafficking of equine infectious anemia virus and human immunodeficiency virus type 1 Gag during viral assembly and budding revealed by bimolecular fluorescence complementation assays.

Authors: Jing Jin; Timothy Sturgeon; Chaoping Chen; Simon C Watkins; Ora A Weisz; Ronald C Montelaro
Journal: J Virol Date: 2007-08-08 Impact factor: 5.103

7. A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein.

Authors: Rahel Byland; Patricia J Vance; James A Hoxie; Mark Marsh
Journal: Mol Biol Cell Date: 2006-11-15 Impact factor: 4.138

Review 8. Modulation of HIV-1-host interaction: role of the Vpu accessory protein.

Authors: Mathieu Dubé; Mariana G Bego; Catherine Paquay; Éric A Cohen
Journal: Retrovirology Date: 2010-12-22 Impact factor: 4.602

Review 9. Host cell factors in HIV replication: meta-analysis of genome-wide studies.

Authors: Frederic D Bushman; Nirav Malani; Jason Fernandes; Iván D'Orso; Gerard Cagney; Tracy L Diamond; Honglin Zhou; Daria J Hazuda; Amy S Espeseth; Renate König; Sourav Bandyopadhyay; Trey Ideker; Stephen P Goff; Nevan J Krogan; Alan D Frankel; John A T Young; Sumit K Chanda
Journal: PLoS Pathog Date: 2009-05-29 Impact factor: 6.823

10. Exploring the functional interaction between POSH and ALIX and the relevance to HIV-1 release.

Authors: Jörg Votteler; Elena Iavnilovitch; Orit Fingrut; Vivian Shemesh; Daniel Taglicht; Omri Erez; Stefan Sörgel; Torsten Walther; Norbert Bannert; Ulrich Schubert; Yuval Reiss
Journal: BMC Biochem Date: 2009-04-24 Impact factor: 4.059

51 in total

Review 1. Virus maturation.

Authors: David Veesler; John E Johnson
Journal: Annu Rev Biophys Date: 2012-02-23 Impact factor: 12.981

New insights into HIV assembly and trafficking.

1. Entropic switch regulates myristate exposure in the HIV-1 matrix protein.

2. HIV-1 egress is gated through late endosomal membranes.

3. The ESCRT pathway and HIV-1 budding.

4. Opposing mechanisms involving RNA and lipids regulate HIV-1 Gag membrane binding through the highly basic region of the matrix domain.

5. Conservation of a stepwise, energy-sensitive pathway involving HP68 for assembly of primate lentivirus capsids in cells.

6. Distinct intracellular trafficking of equine infectious anemia virus and human immunodeficiency virus type 1 Gag during viral assembly and budding revealed by bimolecular fluorescence complementation assays.

7. A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein.

Review 8. Modulation of HIV-1-host interaction: role of the Vpu accessory protein.

Review 9. Host cell factors in HIV replication: meta-analysis of genome-wide studies.

10. Exploring the functional interaction between POSH and ALIX and the relevance to HIV-1 release.

Review 1. Virus maturation.

2. ARRDC1 as a mediator of microvesicle budding.

3. Dynamics of HIV-1 RNA Near the Plasma Membrane during Virus Assembly.

4. Multi-step inhibition explains HIV-1 protease inhibitor pharmacodynamics and resistance.

5. The innate immune factor apolipoprotein L1 restricts HIV-1 infection.

6. Simulations show that virus assembly and budding are facilitated by membrane microdomains.

7. Reevaluation of the requirement for TIP47 in human immunodeficiency virus type 1 envelope glycoprotein incorporation.

8. HIV-1 Gag associates with specific uropod-directed microdomains in a manner dependent on its MA highly basic region.

9. Molecular Determinants Directing HIV-1 Gag Assembly to Virus-Containing Compartments in Primary Macrophages.

Review 10. Roles played by acidic lipids in HIV-1 Gag membrane binding.