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Literature DB >> 20543558

Dynamics of the PI3K-like protein kinase members ATM and DNA-PKcs at DNA double strand breaks.

Anthony J Davis¹, Sairei So, David J Chen.

Abstract

The protein kinases ATM and DNA-PKcs play critical roles in the cellular response to DNA double strand breaks (DSBs). ATM and DNA-PKcs are activated in response to DSBs and play several important roles in propagation of the damage signal and for the repair of DNA damage. Recent work from several groups, including ours, has focused on studying the dynamics of each of these proteins at DSBs and the requirements and factors which play a role(s) in this process. The use of live cell imaging of fluorescently-tagged ATM and DNA-PKcs has allowed us to study the real-time response of these proteins to laser-generated DNA damage in vivo. Here, we will extensively discuss the behavior of the ATM and DNA-PKcs proteins at DSB sites.

Entities: Gene

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Year: 2010 PMID： 20543558 PMCID： PMC3040849 DOI： 10.4161/cc.9.13.12148

Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534

55 in total

1. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair.

Authors: J R Walker; R A Corpina; J Goldberg
Journal: Nature Date: 2001-08-09 Impact factor: 49.962

Review 2. Genome maintenance mechanisms for preventing cancer.

Authors: J H Hoeijmakers
Journal: Nature Date: 2001-05-17 Impact factor: 49.962

3. Activation of DNA-dependent protein kinase by single-stranded DNA ends.

Authors: O Hammarsten; L G DeFazio; G Chu
Journal: J Biol Chem Date: 2000-01-21 Impact factor: 5.157

4. Human Rad50/Mre11 is a flexible complex that can tether DNA ends.

Authors: M de Jager; J van Noort; D C van Gent; C Dekker; R Kanaar; C Wyman
Journal: Mol Cell Date: 2001-11 Impact factor: 17.970

Review 5. ATM and related protein kinases: safeguarding genome integrity.

Authors: Yosef Shiloh
Journal: Nat Rev Cancer Date: 2003-03 Impact factor: 60.716

6. Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks.

Authors: Doug W Chan; Benjamin Ping-Chi Chen; Sheela Prithivirajsingh; Akihiro Kurimasa; Michael D Story; Jun Qin; David J Chen
Journal: Genes Dev Date: 2002-09-15 Impact factor: 11.361

7. Threonines 2638/2647 in DNA-PK are essential for cellular resistance to ionizing radiation.

Authors: Sébastien Soubeyrand; Louise Pope; Benjamin Pakuts; Robert J G Haché
Journal: Cancer Res Date: 2003-03-15 Impact factor: 12.701

8. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.

Authors: Christopher J Bakkenist; Michael B Kastan
Journal: Nature Date: 2003-01-30 Impact factor: 49.962

9. Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase.

Authors: Pauline Douglas; Gopal P Sapkota; Nick Morrice; Yaping Yu; Aaron A Goodarzi; Dennis Merkle; Katheryn Meek; Dario R Alessi; Susan P Lees-Miller
Journal: Biochem J Date: 2002-11-15 Impact factor: 3.857

10. Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex.

Authors: Michal Hammel; Yaping Yu; Brandi L Mahaney; Brandon Cai; Ruiqiong Ye; Barry M Phipps; Robert P Rambo; Greg L Hura; Martin Pelikan; Sairei So; Ramin M Abolfath; David J Chen; Susan P Lees-Miller; John A Tainer
Journal: J Biol Chem Date: 2009-11-05 Impact factor: 5.157

22 in total

1. Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384.

Authors: Andrew J Leiker; William DeGraff; Rajani Choudhuri; Anastasia L Sowers; Angela Thetford; John A Cook; Carter Van Waes; James B Mitchell
Journal: Clin Cancer Res Date: 2015-02-27 Impact factor: 12.531

Review 2. ATM protein kinase: the linchpin of cellular defenses to stress.

Authors: Shahzad Bhatti; Sergei Kozlov; Ammad Ahmad Farooqi; Ali Naqi; Martin Lavin; Kum Kum Khanna
Journal: Cell Mol Life Sci Date: 2011-05-02 Impact factor: 9.261

3. Examining DNA Double-Strand Break Repair in a Cell Cycle-Dependent Manner.

Authors: Janapriya Saha; Shih-Ya Wang; Anthony J Davis
Journal: Methods Enzymol Date: 2017-04-17 Impact factor: 1.600

4. Role of Ku70 in the apoptosis of inflamed dental pulp stem cells.

Authors: Yequan Huang; Weiwei Qiao; Xinhuan Wang; Qian Gao; Yao Peng; Zhuan Bian; Liuyan Meng
Journal: Inflamm Res Date: 2018-07-14 Impact factor: 4.575

5. Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining.

Authors: Wenxia Jiang; Jennifer L Crowe; Xiangyu Liu; Satoshi Nakajima; Yunyue Wang; Chen Li; Brian J Lee; Richard L Dubois; Chao Liu; Xiaochun Yu; Li Lan; Shan Zha
Journal: Mol Cell Date: 2015-03-26 Impact factor: 17.970

6. Imaging of Fluorescently Tagged ATM Kinase at the Sites of DNA Double Strand Breaks.

Authors: Anthony J Davis; Shih-Ya Wang; David J Chen; Benjamin P C Chen
Journal: Methods Mol Biol Date: 2017

7. Detection of early Abl kinase activation after ionizing radiation by using a peptide biosensor.

Authors: Jiabin Tang; Jean Y Wang; Laurie L Parker
Journal: Chembiochem Date: 2012-02-14 Impact factor: 3.164

8. Correct end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context.

Authors: Amanda Gunn; Nicole Bennardo; Anita Cheng; Jeremy M Stark
Journal: J Biol Chem Date: 2011-10-24 Impact factor: 5.157

9. Lysines 3241 and 3260 of DNA-PKcs are important for genomic stability and radioresistance.

Authors: Eiichiro Mori; Anthony J Davis; Masatoshi Hasegawa; David J Chen
Journal: Biochem Biophys Res Commun Date: 2016-06-11 Impact factor: 3.575

10. The Cancer-Associated ATM R3008H Mutation Reveals the Link between ATM Activation and Its Exchange.

Authors: Maja Milanovic; Lisa M Houghton; Demis Menolfi; Ji-Hoon Lee; Kenta Yamamoto; Yang Li; Brian J Lee; Jun Xu; Verna M Estes; Dong Wang; Peter J Mckinnon; Tanya T Paull; Shan Zha
Journal: Cancer Res Date: 2020-11-25 Impact factor: 12.701