| Literature DB >> 20541385 |
Vijay S Gorantla1, Stefan Schneeberger, Gerald Brandacher, Robert Sucher, Dong Zhang, W P Andrew Lee, Xin Xiao Zheng.
Abstract
Despite the development of successful immunosuppression protocols and tremendous improvement in short-term graft survival rates, the problem of chronic graft loss remains the bane of clinical transplantation. The induction and maintenance of transplantation tolerance is the "Holy Grail" of transplantation. The recent identification and characterization of regulatory T cells has opened up exciting opportunities for tolerance induction, immunotherapy, and immunomodulation in transplantation. This review focuses on current understanding of regulatory T cells and their role in transplantation tolerance. Copyright 2010 Elsevier Inc. All rights reserved.Entities:
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Year: 2010 PMID： 20541385 PMCID： PMC2902703 DOI： 10.1016/j.trre.2010.04.002
Source DB: PubMed Journal: Transplant Rev (Orlando) ISSN： 0955-470X Impact factor: 3.943