Literature DB >> 19538489

Human FOXP3+ regulatory T cells in transplantation.

P Boros1, J S Bromberg.   

Abstract

CD4+CD25+FOXP3+ suppressive regulatory T cells (Treg) represent a subset of immune regulatory cells. Based on experimental results, Treg have recently been considered as a potential treatment option in several diseases. Compared with murine Treg, human CD4+CD25+FOXP3+ cells are less well characterized and understood, so a thorough understanding of their biology is vital before clinical applications can be initiated. This review summarizes knowledge on generation, phenotypic characteristics and function of human Treg. The possible role of these cells in organ transplantation, as well as interactions between immunosuppression and Treg are also discussed.

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Year:  2009        PMID： 19538489      PMCID： PMC2724649          DOI： 10.1111/j.1600-6143.2009.02704.x

Source DB:  PubMed          Journal:  Am J Transplant        ISSN： 1600-6135            Impact factor:   8.086


  31 in total

Review 1.  Regulatory T cells in transplantation tolerance.

Authors:  Kathryn J Wood; Shimon Sakaguchi
Journal:  Nat Rev Immunol       Date:  2003-03       Impact factor: 53.106

2.  Messenger RNA for FOXP3 in the urine of renal-allograft recipients.

Authors:  Thangamani Muthukumar; Darshana Dadhania; Ruchuang Ding; Catherine Snopkowski; Rubina Naqvi; Jun B Lee; Choli Hartono; Baogui Li; Vijay K Sharma; Surya V Seshan; Sandip Kapur; Wayne W Hancock; Joseph E Schwartz; Manikkam Suthanthiran
Journal:  N Engl J Med       Date:  2005-12-01       Impact factor: 91.245

3.  Transplantation tolerance induced by regulatory T cells: in vivo mechanisms and sites of action.

Authors:  Dela Golshayan; Jean-Christophe Wyss; Caroline Wyss Abulker; Stephan C Schaefer; Robert I Lechler; Hans-Anton Lehr; Manuel Pascual
Journal:  Int Immunopharmacol       Date:  2009-01-09       Impact factor: 4.932

4.  Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo.

Authors:  Milica Vukmanovic-Stejic; Yan Zhang; Joanne E Cook; Jean M Fletcher; Arthur McQuaid; Joanne E Masters; Malcolm H A Rustin; Leonie S Taams; Peter C L Beverley; Derek C Macallan; Arne N Akbar
Journal:  J Clin Invest       Date:  2006-09       Impact factor: 14.808

Review 5.  Dendritic cells expand antigen-specific Foxp3+ CD25+ CD4+ regulatory T cells including suppressors of alloreactivity.

Authors:  Sayuri Yamazaki; Kayo Inaba; Kristin V Tarbell; Ralph M Steinman
Journal:  Immunol Rev       Date:  2006-08       Impact factor: 12.988

6.  Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells.

Authors:  Jun Wang; Andreea Ioan-Facsinay; Ellen I H van der Voort; Tom W J Huizinga; René E M Toes
Journal:  Eur J Immunol       Date:  2007-01       Impact factor: 5.532

7.  Contrasting CD25hiCD4+T cells/FOXP3 patterns in chronic rejection and operational drug-free tolerance.

Authors:  Stéphanie Louis; Cécile Braudeau; Magali Giral; Alexandre Dupont; Frédérique Moizant; Nelly Robillard; Anne Moreau; Jean-Paul Soulillou; Sophie Brouard
Journal:  Transplantation       Date:  2006-02-15       Impact factor: 4.939

8.  CD4+ CD25+ FOXP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H.

Authors:  D D Bloom; Z Chang; J H Fechner; W Dar; S P Polster; J Pascual; L A Turka; S J Knechtle
Journal:  Am J Transplant       Date:  2008-02-05       Impact factor: 8.086

9.  CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells.

Authors:  Weihong Liu; Amy L Putnam; Zhou Xu-Yu; Gregory L Szot; Michael R Lee; Shirley Zhu; Peter A Gottlieb; Philipp Kapranov; Thomas R Gingeras; Barbara Fazekas de St Groth; Carol Clayberger; David M Soper; Steven F Ziegler; Jeffrey A Bluestone
Journal:  J Exp Med       Date:  2006-07-03       Impact factor: 14.307

10.  Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression.

Authors:  Rui Wang; Qi Wan; Lina Kozhaya; Hodaka Fujii; Derya Unutmaz
Journal:  PLoS One       Date:  2008-07-16       Impact factor: 3.240
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  20 in total

1.  Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade.

Authors:  Andrew M Posselt; Gregory L Szot; Lynda A Frassetto; Umesh Masharani; Mehdi Tavakol; Raj Amin; Joan McElroy; Marissa D Ramos; Robert K Kerlan; Lawrence Fong; Flavio Vincenti; Jeffrey A Bluestone; Peter G Stock
Journal:  Transplantation       Date:  2010-12-27       Impact factor: 4.939

Review 2.  Detecting adaptive immunity: applications in transplantation monitoring.

Authors:  Georg A Böhmig; Markus Wahrmann; Marcus D Säemann
Journal:  Mol Diagn Ther       Date:  2010-02-01       Impact factor: 4.074

3.  FoxP3(+) T regulatory cells in oral lichen planus and its correlation with the distinct clinical appearance of the lesions.

Authors:  Joabe S Pereira; Bárbara V Monteiro; Cassiano F Nonaka; Éricka J Silveira; Márcia C Miguel
Journal:  Int J Exp Pathol       Date:  2012-08       Impact factor: 1.925

4.  Differences in Peripheral Blood Lymphocytes between Brand-Name and Generic Tacrolimus Used in Stable Liver Transplant Recipients.

Authors:  Jong Man Kim; Choon Hyuck David Kwon; Jae-Won Joh; Dong Hyun Sinn; Gyu-Seong Choi; Jae Berm Park; Eun-Suk Kang; Suk-Koo Lee
Journal:  Med Princ Pract       Date:  2017-01-09       Impact factor: 1.927

5.  Ex vivo expansion of human Tregs by rabbit ATG is dependent on intact STAT3-signaling in CD4⁺ T cells and requires the presence of monocytes.

Authors:  O Boenisch; M Lopez; W Elyaman; C N Magee; U Ahmad; N Najafian
Journal:  Am J Transplant       Date:  2012-03-05       Impact factor: 8.086

Review 6.  T regulatory cells and transplantation tolerance.

Authors:  Vijay S Gorantla; Stefan Schneeberger; Gerald Brandacher; Robert Sucher; Dong Zhang; W P Andrew Lee; Xin Xiao Zheng
Journal:  Transplant Rev (Orlando)       Date:  2010-06-11       Impact factor: 3.943

7.  A peptide tetramer Tk-tPN induces tolerance of cardiac allografting by conversion of type 1 to type 2 immune responses via the Toll-like receptor 2 signal-promoted activation of the MCP1 gene.

Authors:  Zuoqing Li; Neng Yang; Ling Zhou; Peng Gu; Hui Wang; Yun Zhou; Peijun Zhou; Liming Lu; Kuang-Yen Chou
Journal:  Immunology       Date:  2016-03       Impact factor: 7.397

8.  Differing effects of rapamycin or calcineurin inhibitor on T-regulatory cells in pediatric liver and kidney transplant recipients.

Authors:  T Akimova; B M Kamath; J W Goebel; K E C Meyers; E B Rand; A Hawkins; M H Levine; J C Bucuvalas; W W Hancock
Journal:  Am J Transplant       Date:  2012-09-20       Impact factor: 8.086

9.  Islet transplantation in type 1 diabetics using an immunosuppressive protocol based on the anti-LFA-1 antibody efalizumab.

Authors:  A M Posselt; M D Bellin; M Tavakol; G L Szot; L A Frassetto; U Masharani; R K Kerlan; L Fong; F G Vincenti; B J Hering; J A Bluestone; P G Stock
Journal:  Am J Transplant       Date:  2010-08       Impact factor: 8.086

10.  Tracking immune cell proliferation and cytotoxic potential using flow cytometry.

Authors:  Joseph D Tario; Katharine A Muirhead; Dalin Pan; Mark E Munson; Paul K Wallace
Journal:  Methods Mol Biol       Date:  2011
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