Literature DB >> 20533502

HTS and rational drug design to generate a class of 5-HT(2C)-selective ligands for possible use in schizophrenia.

Alan P Kozikowski1, Sung Jin Cho, Niels H Jensen, John A Allen, Andreas M Svennebring, Bryan L Roth.   

Abstract

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20533502      PMCID： PMC2951742          DOI： 10.1002/cmdc.201000186

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


× No keyword cloud information.
  26 in total

Review 1.  5-Hydroxytryptamine 2C (5-HT2C) receptor agonists as potential antiobesity agents.

Authors:  Björn M Nilsson
Journal:  J Med Chem       Date:  2006-07-13       Impact factor: 7.446

Review 2.  Selective agents for serotonin2C (5-HT2C) receptor.

Authors:  Enza Lacivita; Marcello Leopoldo
Journal:  Curr Top Med Chem       Date:  2006       Impact factor: 3.295

3.  Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications.

Authors:  R B Rothman; M H Baumann; J E Savage; L Rauser; A McBride; S J Hufeisen; B L Roth
Journal:  Circulation       Date:  2000-12-05       Impact factor: 29.690

Review 4.  Serotonin 5-ht2c receptor agonists: potential for the treatment of obesity.

Authors:  Keith J Miller
Journal:  Mol Interv       Date:  2005-10

5.  Enhanced locomotor, reinforcing, and neurochemical effects of cocaine in serotonin 5-hydroxytryptamine 2C receptor mutant mice.

Authors:  Beatriz A Rocha; Evan H Goulding; Laura E O'Dell; Andy N Mead; Nicole G Coufal; Loren H Parsons; Laurence H Tecott
Journal:  J Neurosci       Date:  2002-11-15       Impact factor: 6.167

Review 6.  Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review.

Authors:  M A Geyer; K Krebs-Thomson; D L Braff; N R Swerdlow
Journal:  Psychopharmacology (Berl)       Date:  2001-07       Impact factor: 4.530

7.  Compulsive behavior in the 5-HT2C receptor knockout mouse.

Authors:  Jennifer M Chou-Green; Todd D Holscher; Mary F Dallman; Susan F Akana
Journal:  Physiol Behav       Date:  2003-04

Review 8.  Hallucinogens.

Authors:  David E Nichols
Journal:  Pharmacol Ther       Date:  2004-02       Impact factor: 12.310

Review 9.  Molecular biology of serotonin receptors structure and function at the molecular level.

Authors:  Wesley K Kroeze; Kurt Kristiansen; Bryan L Roth
Journal:  Curr Top Med Chem       Date:  2002-06       Impact factor: 3.295

Review 10.  Animal behavior models of the mechanisms underlying antipsychotic atypicality.

Authors:  Mark A Geyer; Bart Ellenbroek
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2003-10       Impact factor: 5.067
View more
  12 in total

1.  Rational Drug Design Leading to the Identification of a Potent 5-HT(2C) Agonist Lacking 5-HT(2B) Activity.

Authors:  Gang Chen; Sung Jin Cho; Xi-Ping Huang; Niels H Jensen; Andreas Svennebring; Maria F Sassano; Bryan L Roth; Alan P Kozikowski
Journal:  ACS Med Chem Lett       Date:  2011-10-10       Impact factor: 4.345

2.  Irving Page Lecture: 5-HT(2A) serotonin receptor biology: interacting proteins, kinases and paradoxical regulation.

Authors:  Bryan L Roth
Journal:  Neuropharmacology       Date:  2011-02-01       Impact factor: 5.250

3.  Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents.

Authors:  Jianjun Cheng; Patrick M Giguère; Oluseye K Onajole; Wei Lv; Arsen Gaisin; Hendra Gunosewoyo; Claire M Schmerberg; Vladimir M Pogorelov; Ramona M Rodriguiz; Giulio Vistoli; William C Wetsel; Bryan L Roth; Alan P Kozikowski
Journal:  J Med Chem       Date:  2015-02-10       Impact factor: 7.446

Review 4.  Serotonin receptors and heart valve disease--it was meant 2B.

Authors:  Joshua D Hutcheson; Vincent Setola; Bryan L Roth; W David Merryman
Journal:  Pharmacol Ther       Date:  2011-04-02       Impact factor: 12.310

5.  A fluoride-derived electrophilic late-stage fluorination reagent for PET imaging.

Authors:  Eunsung Lee; Adam S Kamlet; David C Powers; Constanze N Neumann; Gregory B Boursalian; Takeru Furuya; Daniel C Choi; Jacob M Hooker; Tobias Ritter
Journal:  Science       Date:  2011-11-04       Impact factor: 47.728

Review 6.  "Selective" serotonin 5-HT2A receptor antagonists.

Authors:  Austen B Casey; Meng Cui; Raymond G Booth; Clinton E Canal
Journal:  Biochem Pharmacol       Date:  2022-04-04       Impact factor: 6.100

7.  Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models.

Authors:  Jianjun Cheng; Patrick M Giguere; Claire M Schmerberg; Vladimir M Pogorelov; Ramona M Rodriguiz; Xi-Ping Huang; Hu Zhu; John D McCorvy; William C Wetsel; Bryan L Roth; Alan P Kozikowski
Journal:  J Med Chem       Date:  2016-01-13       Impact factor: 7.446

8.  We Need 2C but Not 2B: Developing Serotonin 2C (5-HT2C) Receptor Agonists for the Treatment of CNS Disorders.

Authors:  Jianjun Cheng; Alan P Kozikowski
Journal:  ChemMedChem       Date:  2015-10-28       Impact factor: 3.466

9.  Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings.

Authors:  Gabriel S Dichter; Cara A Damiano; John A Allen
Journal:  J Neurodev Disord       Date:  2012-07-06       Impact factor: 4.025

10.  Application of palladium-mediated (18)F-fluorination to PET radiotracer development: overcoming hurdles to translation.

Authors:  Adam S Kamlet; Constanze N Neumann; Eunsung Lee; Stephen M Carlin; Christian K Moseley; Nickeisha Stephenson; Jacob M Hooker; Tobias Ritter
Journal:  PLoS One       Date:  2013-03-12       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.