Literature DB >> 21288474

Irving Page Lecture: 5-HT(2A) serotonin receptor biology: interacting proteins, kinases and paradoxical regulation.

Bryan L Roth1.   

Abstract

5-Hydroxytryptamine(2A) (5-HT(2A)) serotonin receptors are important pharmacological targets for a large number of central nervous system and peripheral serotonergic medications. In this review article I summarize work mainly from my lab regarding serotonin receptor anatomy, pharmacology, signaling and regulation. I highlight the role of serotonin receptor interacting proteins and the emerging paradigm of G-protein coupled receptor functional selectivity.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21288474      PMCID： PMC3110590          DOI： 10.1016/j.neuropharm.2011.01.012

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  118 in total

1.  HTS and rational drug design to generate a class of 5-HT(2C)-selective ligands for possible use in schizophrenia.

Authors:  Alan P Kozikowski; Sung Jin Cho; Niels H Jensen; John A Allen; Andreas M Svennebring; Bryan L Roth
Journal:  ChemMedChem       Date:  2010-08-02       Impact factor: 3.466

Review 2.  G-protein-coupled receptors at a glance.

Authors:  Wesley K Kroeze; Douglas J Sheffler; Bryan L Roth
Journal:  J Cell Sci       Date:  2003-12-15       Impact factor: 5.285

3.  Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex.

Authors:  Elizabeth A Pehek; Christine Nocjar; Bryan L Roth; Tara A Byrd; Omar S Mabrouk
Journal:  Neuropsychopharmacology       Date:  2006-02       Impact factor: 7.853

Review 4.  Regulation of 5-HT2 and 5-HT1C serotonin receptor levels. Methodology and mechanisms.

Authors:  B L Roth; M Hamblin; R D Ciaranello
Journal:  Neuropsychopharmacology       Date:  1990 Oct-Dec       Impact factor: 7.853

5.  PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors.

Authors:  Atheir I Abbas; Prem N Yadav; Wei-Dong Yao; Margaret I Arbuckle; Seth G N Grant; Marc G Caron; Bryan L Roth
Journal:  J Neurosci       Date:  2009-06-03       Impact factor: 6.167

Review 6.  The molecular biology of serotonin receptors: therapeutic implications for the interface of mood and psychosis.

Authors:  W K Kroeze; B L Roth
Journal:  Biol Psychiatry       Date:  1998-12-01       Impact factor: 13.382

7.  Regulation of 5-hydroxytryptamine2 (5-HT2) receptor expression in cultured rat aortic smooth muscle cells by SR 46349B, a selective 5-HT2 receptor antagonist.

Authors:  M Rinaldi-Carmona; V Prabonnaud; M Bouaboula; C Poinot-Chazel; P Casellas; G Le Fur; J M Herbert
Journal:  J Biol Chem       Date:  1994-01-07       Impact factor: 5.157

Review 8.  Agonist-receptor efficacy. II. Agonist trafficking of receptor signals.

Authors:  T Kenakin
Journal:  Trends Pharmacol Sci       Date:  1995-07       Impact factor: 14.819

9.  Different synaptic location of mianserin and imipramine binding sites.

Authors:  N Brunello; D M Chuang; E Costa
Journal:  Science       Date:  1982-02-26       Impact factor: 47.728

10.  Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents.

Authors:  R A Glennon; M Titeler; J D McKenney
Journal:  Life Sci       Date:  1984-12-17       Impact factor: 5.037
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  20 in total

Review 1.  Head-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model.

Authors:  Clint E Canal; Drake Morgan
Journal:  Drug Test Anal       Date:  2012-04-19       Impact factor: 3.345

Review 2.  Psychiatric drugs bind to classical targets within early exocytotic pathways: therapeutic effects.

Authors:  Henry A Lester; Julie M Miwa; Rahul Srinivasan
Journal:  Biol Psychiatry       Date:  2012-07-06       Impact factor: 13.382

3.  G-protein receptor kinase 5 regulates the cannabinoid receptor 2-induced up-regulation of serotonin 2A receptors.

Authors:  Jade M Franklin; Gonzalo A Carrasco
Journal:  J Biol Chem       Date:  2013-04-16       Impact factor: 5.157

Review 4.  Serotonergic targets for the treatment of L-DOPA-induced dyskinesia.

Authors:  Kathryn Lanza; Christopher Bishop
Journal:  J Neural Transm (Vienna)       Date:  2018-01-05       Impact factor: 3.575

5.  ERK Is a Critical Regulator of JC Polyomavirus Infection.

Authors:  Jeanne K DuShane; Michael P Wilczek; Colleen L Mayberry; Melissa S Maginnis
Journal:  J Virol       Date:  2018-03-14       Impact factor: 5.103

6.  Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT2C protomers.

Authors:  Imane Moutkine; Emily Quentin; Bruno P Guiard; Luc Maroteaux; Stephane Doly
Journal:  J Biol Chem       Date:  2017-03-03       Impact factor: 5.157

7.  Cannabinoid 2 receptor- and beta Arrestin 2-dependent upregulation of serotonin 2A receptors.

Authors:  J M Franklin; T Vasiljevik; T E Prisinzano; G A Carrasco
Journal:  Eur Neuropsychopharmacol       Date:  2012-07-28       Impact factor: 4.600

8.  Cannabinoid receptor agonists upregulate and enhance serotonin 2A (5-HT(2A)) receptor activity via ERK1/2 signaling.

Authors:  Jade M Franklin; Gonzalo A Carrasco
Journal:  Synapse       Date:  2012-12-08       Impact factor: 2.562

9.  Cannabinoid-induced upregulation of serotonin 2A receptors in the hypothalamic paraventricular nucleus and anxiety-like behaviors in rats.

Authors:  Jade M Franklin; Matt Mathew; Gonzalo A Carrasco
Journal:  Neurosci Lett       Date:  2013-05-27       Impact factor: 3.046

10.  Biochemistry. As good as chocolate.

Authors:  Krzysztof Palczewski; Philip D Kiser
Journal:  Science       Date:  2013-05-03       Impact factor: 47.728
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