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Literature DB >> 20532693

Ovarian tumors with elevated CA-125 levels and severe juvenile hypothyroidism: a need for increased awareness.

Sriram Krishnamurthy¹, Anju Seth, Archana Puri, Rama Anand, Satinder Aneja.

Abstract

A 15-yr-old girl presented with bilateral gross ovarian tumors, clinical features of long-standing unrecognized hypothyroidism and markedly elevated CA-125 levels. Ovarian resection was avoided, as the presentation was consistent with the Van Wyk and Grumbach syndrome; and the patient was treated with replacement of thyroid hormone. Regression of the ovarian tumors occurred 6 months after initiation of the treatment. The authors emphasise the need for increased awareness and screening for hypothyroidism in patients with ovarian tumors, in order to prevent inadvertent operative interventions.

Entities: Disease Gene Species

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Year: 2010 PMID： 20532693 DOI： 10.1007/s12098-010-0081-6

Source DB: PubMed Journal: Indian J Pediatr ISSN： 0019-5456 Impact factor: 1.967

9 in total

2 in total

1. Spontaneous ovarian hyperstimulation syndrome and pituitary hyperplasia mimicking macroadenoma associated with primary hypothyroidism.

Authors: Rene Epunza Kanza; Sylvain Gagnon; Helene Villeneuve; David Laverdiere; Isabelle Rousseau; Edith Bordeleau; Michel Berube
Journal: World J Radiol Date: 2013-01-28

2. Van Wyk-Grumbach syndrome in a female pediatric patient with trisomy 21: a case report.

Authors: Jyotsna Gupta; Karen Lin-Su
Journal: Int J Pediatr Endocrinol Date: 2020-01-28

2 in total

Ovarian tumors with elevated CA-125 levels and severe juvenile hypothyroidism: a need for increased awareness.

1. Investigation of gonadotropin-thyrotropin overlapping and hormonal imprinting in the rat testis.

2. Ovarian cysts in young girls with hypothyroidism: follow-up and effect of treatment.

3. Acute abdomen and hypothyroidism.

4. Primary hypothyroidism presenting as ovarian tumor and precocious puberty in a prepubertal girl.

5. Van Wyk and Grumbach syndrome revisited: imaging and clinical findings in pre- and postpubertal girls.

6. Multiple ovarian cysts in a young girl with severe hypothyroidism.

7. A potential novel mechanism for precocious puberty in juvenile hypothyroidism.

8. Ovarian tumor in a 12-year old female with severe hypothyroidism: A case of Van Wyk and Grumbach syndrome.

9. Polycystic ovaries, precocious puberty and acquired hypothyroidism: The Van Wyk and Grumbach syndrome.

1. Spontaneous ovarian hyperstimulation syndrome and pituitary hyperplasia mimicking macroadenoma associated with primary hypothyroidism.

2. Van Wyk-Grumbach syndrome in a female pediatric patient with trisomy 21: a case report.