PURPOSE: The aim of this study is to assess the capability of endocytoscopy (ECS) in differentiating neoplastic from nonneoplastic lesions in the colorectum and to validate an ECS classification. METHODS: Patients with colorectal polypoid and nonpolypoid lesions < or =10 mm were prospectively included. ECS classification subgrouped nonneoplastic (EC 0) and neoplastic (EC 1-3) lesions. Lesions were observed at super-magnified view (450x) before endoscopic resection. Blinded pathological assessment was obtained. RESULTS: Fifty-two lesions were examined in 49 patients (17 polypoid and 35 nonpolypoid). Final pathological diagnosis was normal mucosa or hyperplastic polyp in ten cases, low-grade adenoma in 29, high-grade adenoma in 11, and submucosal invasive cancer in two cases. Positive predictive values of each EC group were 100%, 93.1%, 90.1%, and 100%, respectively. ECS diagnosis correlated completely with pathology in the differentiation between neoplastic and nonneoplastic lesions. CONCLUSIONS: ECS enabled observation of colorectal lesion at a subcellular level in vivo. The classification of ECS images had a good correlation with the final pathological diagnosis. ECS was useful to differentiate between neoplastic and nonneoplastic lesions.
PURPOSE: The aim of this study is to assess the capability of endocytoscopy (ECS) in differentiating neoplastic from nonneoplastic lesions in the colorectum and to validate an ECS classification. METHODS:Patients with colorectal polypoid and nonpolypoid lesions < or =10 mm were prospectively included. ECS classification subgrouped nonneoplastic (EC 0) and neoplastic (EC 1-3) lesions. Lesions were observed at super-magnified view (450x) before endoscopic resection. Blinded pathological assessment was obtained. RESULTS: Fifty-two lesions were examined in 49 patients (17 polypoid and 35 nonpolypoid). Final pathological diagnosis was normal mucosa or hyperplastic polyp in ten cases, low-grade adenoma in 29, high-grade adenoma in 11, and submucosal invasive cancer in two cases. Positive predictive values of each EC group were 100%, 93.1%, 90.1%, and 100%, respectively. ECS diagnosis correlated completely with pathology in the differentiation between neoplastic and nonneoplastic lesions. CONCLUSIONS: ECS enabled observation of colorectal lesion at a subcellular level in vivo. The classification of ECS images had a good correlation with the final pathological diagnosis. ECS was useful to differentiate between neoplastic and nonneoplastic lesions.
Authors: L Cipolletta; M A Bianco; M L Garofano; C Meucci; R Piscopo; F Cipolletta; R Salerno; S Sansone; G Rotondano Journal: Dig Liver Dis Date: 2009-07-10 Impact factor: 4.088
Authors: K-I Fu; Y Sano; S Kato; T Fujii; F Nagashima; T Yoshino; T Okuno; S Yoshida; T Fujimori Journal: Endoscopy Date: 2004-12 Impact factor: 10.093
Authors: L Cipolletta; M A Bianco; G Rotondano; R Piscopo; C Meucci; A Prisco; F Cipolletta; A de Gregorio; A Salvati Journal: Endoscopy Date: 2009-02-12 Impact factor: 10.093
Authors: Yutaka Tomizawa; Prasad G Iyer; Louis M Wongkeesong; Navtej S Buttar; Lori S Lutzke; Tsung-Teh Wu; Kenneth K Wang Journal: World J Gastroenterol Date: 2013-12-14 Impact factor: 5.742
Authors: Ralf Kiesslich; Martin Goetz; Arthur Hoffman; Peter Robert Galle Journal: Nat Rev Gastroenterol Hepatol Date: 2011-09-06 Impact factor: 46.802